Incompatibility between the gastro-resistant coating and
self-emulsifying pellets described using ss-NMR

k 2024

Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR

MACKŮ, Jan, David VETCHÝ, Kateřina KUBOVÁ, Martina ČUBOVÁ URBANOVÁ, Jiří BRUS et. al.

Základní údaje

Originální název

Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR

Autoři

MACKŮ, Jan, David VETCHÝ, Kateřina KUBOVÁ, Martina ČUBOVÁ URBANOVÁ, Jiří BRUS, Jan MUSELÍK a Jakub VYSLOUŽIL

Vydání

2024

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

thymol; solid self-emulsifying systems; ssNMR; pellets; stability; pellet coating

Štítky

ÚFT

Změněno: 15. 4. 2024 10:47, doc. PharmDr. Kateřina Kubová, Ph.D.

Anotace

V originále

Incorporation of lipophilic drugs into liquid self-emulsifying systems proves to be an effective strategy for augmenting their solubility and bioavailability. Presently, there is a significant focus on exploring the potential of solidifying these systems, e.g., the formulation of pellets through extrusion/spheronization. Solid systems offer numerous advantages, including ease of dosing, manipulability, and enhanced stability. Nonetheless, the broader utilization of self-emulsifying systems would greatly benefit from the modified release, e.g., enabling drug delivery to distal regions of the intestine for oral application. Regrettably, the scientific community has provided limited information on this topic. Although some information exists regarding challenges in coated self-emulsifying pellets, comprehensive investigations remain scarce. This experimental study aims to formulate self-emulsifying pellets coated with Eudragit® L for precise drug delivery to the small intestinal region and to provide a detailed analysis and explanation of the observed difficulties. In this experimental study, dissolution profiles after three months suggest that introducing a sub-layer and TEC reduction could be a solution for the modified release of self-emulsifying pellets. Lastly, it would be advantageous to identify whether self-emulsifying formulation, thymol, or a different variable is a source of presented incompatibility.

Návaznosti

GA22-03187S, projekt VaV

Název: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic (Akronym: 22-03187S)

Investor: Grantová agentura ČR, Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spektrem biologické aktivity k terapii sliznic

Citovat

MACKŮ, Jan, David VETCHÝ, Kateřina KUBOVÁ, Martina ČUBOVÁ URBANOVÁ, Jiří BRUS, Jan MUSELÍK a Jakub VYSLOUŽIL. Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR. 2024.

@proceedings{2394157,
   author = {Macků, Jan and Vetchý, David and Kubová, Kateřina and Čubová Urbanová, Martina and Brus, Jiří and Muselík, Jan and Vysloužil, Jakub},
   keywords = {thymol; solid self-emulsifying systems; ssNMR; pellets; stability; pellet coating},
   language = {eng},
   title = {Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR},
   url = {https://www.worldmeeting.org/home/},
   year = {2024}
}

TY  - CONF
ID  - 2394157
AU  - Macků, Jan - Vetchý, David - Kubová, Kateřina - Čubová Urbanová, Martina - Brus, Jiří - Muselík, Jan - Vysloužil, Jakub
PY  - 2024
TI  - Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR
KW  - thymol
KW  - solid self-emulsifying systems
KW  - ssNMR
KW  - pellets
KW  - stability
KW  - pellet coating
UR  - https://www.worldmeeting.org/home/
N2  - Incorporation of lipophilic drugs into liquid self-emulsifying systems proves to be an effective strategy for augmenting their solubility and bioavailability. Presently, there is a significant focus on exploring the potential of solidifying these systems, e.g., the formulation of pellets through extrusion/spheronization. Solid systems offer numerous advantages, including ease of dosing, manipulability, and enhanced stability. Nonetheless, the broader utilization of self-emulsifying systems would greatly benefit from the modified release, e.g., enabling drug delivery to distal regions of the intestine for oral application. Regrettably, the scientific community has provided limited information on this topic. Although some information exists regarding challenges in coated self-emulsifying pellets, comprehensive investigations remain scarce. This experimental study aims to formulate self-emulsifying pellets coated with Eudragit® L for precise drug delivery to the small intestinal region and to provide a detailed analysis and explanation of the observed difficulties. In this experimental study, dissolution profiles after three months suggest that introducing a sub-layer and TEC reduction could be a solution for the modified release of self-emulsifying pellets. Lastly, it would be advantageous to identify whether self-emulsifying formulation, thymol, or a different variable is a source of presented incompatibility.
ER  -

MACKŮ, Jan, David VETCHÝ, Kateřina KUBOVÁ, Martina ČUBOVÁ URBANOVÁ, Jiří BRUS, Jan MUSELÍK a Jakub VYSLOUŽIL. \textit{Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR}. 2024.

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