Facial emotion processing in patients with borderline
personality disorder as compared with healthy controls: an fMRI
and ECG study

J 2024

Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study

RADIMECKÁ, Monika, Adéla LÁTALOVÁ, Martin LAMOŠ, Martin JÁNI, Patrik BARTYS et. al.

Basic information

Original name

Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study

Authors

RADIMECKÁ, Monika (203 Czech Republic, belonging to the institution), Adéla LÁTALOVÁ (203 Czech Republic, belonging to the institution), Martin LAMOŠ (203 Czech Republic, belonging to the institution), Martin JÁNI (703 Slovakia, belonging to the institution), Patrik BARTYS (203 Czech Republic, belonging to the institution), Alena DAMBORSKÁ (203 Czech Republic, belonging to the institution), Pavel THEINER (203 Czech Republic, belonging to the institution) and Pavla LINHARTOVÁ (203 Czech Republic, belonging to the institution)

Edition

BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION, London, BMC, 2024, 2051-6673

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30215 Psychiatry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.100 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s40479-024-00245-4

UT WoS

001163103200001

Keywords in English

Borderline personality disorder; Facial emotion processing; Negative facial expressions; Faces task; fMRI; Heart rate variability

Abstract

V originále

BackgroundMaladaptive behaviors and interpersonal difficulties in patients with borderline personality disorder (BPD) seem connected to biased facial emotion processing. This bias is often accompanied by heightened amygdala activity in patients with BPD as compared to healthy controls. However, functional magnetic resonance imaging (fMRI) studies exploring differences between patients and healthy controls in facial emotion processing have produced divergent results. The current study explored fMRI and heart rate variability (HRV) correlates of negative facial emotion processing in patients with BPD and healthy controls.MethodsThe study included 30 patients with BPD (29 females; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 females; M = 24.66, SD = 5.28). All participants underwent the "faces" task, an emotional face perception task, in an fMRI session simultaneously with ECG. In this task, participants are presented with emotional expressions of disgust, sadness, and fear (as a negative condition) and with the same pictures in a scrambled version (as a neutral condition).ResultsWe found no differences in brain activity between patients with BPD and healthy controls when processing negative facial expressions as compared to neutral condition. We observed activation in large-scale brain areas in both groups when presented with negative facial expressions as compared to neutral condition. Patients with BPD displayed lower HRV than healthy controls in both conditions. However, there were no significant associations between HRV and amygdala activity and BPD symptoms.ConclusionThe results of this study indicate no abnormal brain activity during emotional facial processing in patients with BPD. This result contrasts with previous studies and more studies are needed to clarify the relationship between facial emotion processing and brain activity in patients with BPD. Possible reasons for the absence of brain activity differences are discussed in the study. Consistent with previous findings, patients showed lower HRV than healthy controls. However, HRV was not associated with amygdala activity and BPD symptoms.

Links

LM2023050, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR, Czech BioImaging: National research infrastructure for biological and medical imaging

MUNI/A/1392/2022, interní kód MU

Name: Inovativní výzkum náboženství perspektivou digitálních humanitních věd

Investor: Masaryk University, Innovative research of religions in the perspective of Digital Humanities

NU20-04-00410, research and development project

Name: Neurální mechanismy dialektické behaviorální terapie u pacientů s hraniční poruchou osobnosti (Acronym: NU20-04-00410)

Investor: Ministry of Health of the CR, Subprogram 1 - standard

Citovat

RADIMECKÁ, Monika, Adéla LÁTALOVÁ, Martin LAMOŠ, Martin JÁNI, Patrik BARTYS, Alena DAMBORSKÁ, Pavel THEINER and Pavla LINHARTOVÁ. Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study. BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION. London: BMC, 2024, vol. 11, No 1, p. 1-14. ISSN 2051-6673. Available from: https://dx.doi.org/10.1186/s40479-024-00245-4.

@article{2394357,
   author = {Radimecká, Monika and Látalová, Adéla and Lamoš, Martin and Jáni, Martin and Bartys, Patrik and Damborská, Alena and Theiner, Pavel and Linhartová, Pavla},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s40479-024-00245-4},
   keywords = {Borderline personality disorder; Facial emotion processing; Negative facial expressions; Faces task; fMRI; Heart rate variability},
   language = {eng},
   issn = {2051-6673},
   journal = {BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION},
   title = {Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study},
   url = {https://bpded.biomedcentral.com/articles/10.1186/s40479-024-00245-4},
   volume = {11},
   year = {2024}
}

TY  - JOUR
ID  - 2394357
AU  - Radimecká, Monika - Látalová, Adéla - Lamoš, Martin - Jáni, Martin - Bartys, Patrik - Damborská, Alena - Theiner, Pavel - Linhartová, Pavla
PY  - 2024
TI  - Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study
JF  - BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
VL  - 11
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - BMC
SN  - 20516673
KW  - Borderline personality disorder
KW  - Facial emotion processing
KW  - Negative facial expressions
KW  - Faces task
KW  - fMRI
KW  - Heart rate variability
UR  - https://bpded.biomedcentral.com/articles/10.1186/s40479-024-00245-4
N2  - BackgroundMaladaptive behaviors and interpersonal difficulties in patients with borderline personality disorder (BPD) seem connected to biased facial emotion processing. This bias is often accompanied by heightened amygdala activity in patients with BPD as compared to healthy controls. However, functional magnetic resonance imaging (fMRI) studies exploring differences between patients and healthy controls in facial emotion processing have produced divergent results. The current study explored fMRI and heart rate variability (HRV) correlates of negative facial emotion processing in patients with BPD and healthy controls.MethodsThe study included 30 patients with BPD (29 females; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 females; M = 24.66, SD = 5.28). All participants underwent the "faces" task, an emotional face perception task, in an fMRI session simultaneously with ECG. In this task, participants are presented with emotional expressions of disgust, sadness, and fear (as a negative condition) and with the same pictures in a scrambled version (as a neutral condition).ResultsWe found no differences in brain activity between patients with BPD and healthy controls when processing negative facial expressions as compared to neutral condition. We observed activation in large-scale brain areas in both groups when presented with negative facial expressions as compared to neutral condition. Patients with BPD displayed lower HRV than healthy controls in both conditions. However, there were no significant associations between HRV and amygdala activity and BPD symptoms.ConclusionThe results of this study indicate no abnormal brain activity during emotional facial processing in patients with BPD. This result contrasts with previous studies and more studies are needed to clarify the relationship between facial emotion processing and brain activity in patients with BPD. Possible reasons for the absence of brain activity differences are discussed in the study. Consistent with previous findings, patients showed lower HRV than healthy controls. However, HRV was not associated with amygdala activity and BPD symptoms.
ER  -

RADIMECKÁ, Monika, Adéla LÁTALOVÁ, Martin LAMOŠ, Martin JÁNI, Patrik BARTYS, Alena DAMBORSKÁ, Pavel THEINER and Pavla LINHARTOVÁ. Facial emotion processing in patients with borderline personality disorder as compared with healthy controls: an fMRI and ECG study. \textit{BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION}. London: BMC, 2024, vol.~11, No~1, p.~1-14. ISSN~2051-6673. Available from: https://dx.doi.org/10.1186/s40479-024-00245-4.

Detailed Information on Publication Record