Regulation of Neuroendocrine-like Differentiation in Prostate
Cancer by Non-Coding RNAs

J 2021

Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs

SLABÁKOVÁ, Eva, Zuzana KAHOUNOVA, Jiřina PROCHÁZKOVÁ a Karel SOUČEK

Základní údaje

Originální název

Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs

Autoři

SLABÁKOVÁ, Eva, Zuzana KAHOUNOVA, Jiřina PROCHÁZKOVÁ a Karel SOUČEK

Vydání

Non-coding RNA, Švýcarsko, MDPI, 2021, 2311-553X

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

DOI

http://dx.doi.org/10.3390/ncrna7040075

UT WoS

000913831400001

Klíčová slova anglicky

neuroendocrine differentiation/transdifferentiation; microRNA; lncRNA; prostate cancer; patients' dataset; liquid biomarkers; exosomes; extracellular vesicles

Štítky

RIV ne

Změněno: 24. 4. 2024 13:19, Mgr. Jiřina Procházková, Ph.D.

Anotace

V originále

Neuroendocrine prostate cancer (NEPC) represents a variant of prostate cancer that occurs in response to treatment resistance or, to a much lesser extent, de novo. Unravelling the molecular mechanisms behind transdifferentiation of cancer cells to neuroendocrine-like cancer cells is essential for development of new treatment opportunities. This review focuses on summarizing the role of small molecules, predominantly microRNAs, in this phenomenon. A published literature search was performed to identify microRNAs, which are reported and experimentally validated to modulate neuroendocrine markers and/or regulators and to affect the complex neuroendocrine phenotype. Next, available patients' expression datasets were surveyed to identify deregulated microRNAs, and their effect on NEPC and prostate cancer progression is summarized. Finally, possibilities of miRNA detection and quantification in body fluids of prostate cancer patients and their possible use as liquid biopsy in prostate cancer monitoring are discussed. All the addressed clinical and experimental contexts point to an association of NEPC with upregulation of miR-375 and downregulation of miR-34a and miR-19b-3p. Together, this review provides an overview of different roles of non-coding RNAs in the emergence of neuroendocrine prostate cancer.

Citovat

SLABÁKOVÁ, Eva, Zuzana KAHOUNOVA, Jiřina PROCHÁZKOVÁ a Karel SOUČEK. Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs. Non-coding RNA. Švýcarsko: MDPI, 2021, roč. 7, č. 4, 40 s. ISSN 2311-553X. Dostupné z: https://dx.doi.org/10.3390/ncrna7040075.

@article{2396642,
   author = {Slabáková, Eva and Kahounova, Zuzana and Procházková, Jiřina and Souček, Karel},
   article_location = {Švýcarsko},
   article_number = {4},
   doi = {http://dx.doi.org/10.3390/ncrna7040075},
   keywords = {neuroendocrine differentiation/transdifferentiation; microRNA; lncRNA; prostate cancer; patients' dataset; liquid biomarkers; exosomes; extracellular vesicles},
   issn = {2311-553X},
   journal = {Non-coding RNA},
   title = {Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs},
   volume = {7},
   year = {2021}
}

TY  - JOUR
ID  - 2396642
AU  - Slabáková, Eva - Kahounova, Zuzana - Procházková, Jiřina - Souček, Karel
PY  - 2021
TI  - Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs
JF  - Non-coding RNA
VL  - 7
IS  - 4
PB  - MDPI
SN  - 2311553X
KW  - neuroendocrine differentiation/transdifferentiation
KW  - microRNA
KW  - lncRNA
KW  - prostate cancer
KW  - patients' dataset
KW  - liquid biomarkers
KW  - exosomes
KW  - extracellular vesicles
N2  - Neuroendocrine prostate cancer (NEPC) represents a variant of prostate cancer that occurs in response to treatment resistance or, to a much lesser extent, de novo. Unravelling the molecular mechanisms behind transdifferentiation of cancer cells to neuroendocrine-like cancer cells is essential for development of new treatment opportunities. This review focuses on summarizing the role of small molecules, predominantly microRNAs, in this phenomenon. A published literature search was performed to identify microRNAs, which are reported and experimentally validated to modulate neuroendocrine markers and/or regulators and to affect the complex neuroendocrine phenotype. Next, available patients' expression datasets were surveyed to identify deregulated microRNAs, and their effect on NEPC and prostate cancer progression is summarized. Finally, possibilities of miRNA detection and quantification in body fluids of prostate cancer patients and their possible use as liquid biopsy in prostate cancer monitoring are discussed. All the addressed clinical and experimental contexts point to an association of NEPC with upregulation of miR-375 and downregulation of miR-34a and miR-19b-3p. Together, this review provides an overview of different roles of non-coding RNAs in the emergence of neuroendocrine prostate cancer.
ER  -

SLABÁKOVÁ, Eva, Zuzana KAHOUNOVA, Jiřina PROCHÁZKOVÁ a Karel SOUČEK. Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs. \textit{Non-coding RNA}. Švýcarsko: MDPI, 2021, roč.~7, č.~4, 40 s. ISSN~2311-553X. Dostupné z: https://dx.doi.org/10.3390/ncrna7040075.

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