Persisting IL-18 levels after COVID-19 correlate with markers
of cardiovascular inflammation reflecting potential risk of
CVDs development

J 2024

Persisting IL-18 levels after COVID-19 correlate with markers of cardiovascular inflammation reflecting potential risk of CVDs development

ANDREJČINOVÁ, Ivana; Gabriela BLAZKOVA; Ioanna PAPATHEODOROU; Kamila BENDÍČKOVÁ; Veronika BOSÁKOVÁ et al.

Základní údaje

Originální název

Persisting IL-18 levels after COVID-19 correlate with markers of cardiovascular inflammation reflecting potential risk of CVDs development

Autoři

Vydání

Heliyon, OXFORD, ELSEVIER SCI LTD, 2024, 2405-8440

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.600

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00135928

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

COVID-19; Inflammation; CVDs; COVID-19 long-term consequences; IL-18

Štítky

14110115, 14110122, 14110132, 14110513, 14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 5. 2024 07:54, Mgr. Tereza Miškechová

Anotace

V originále

COVID-19 manifestation is associated with a strong immune system activation leading to inflammation and subsequently affecting the cardiovascular system. The objective of the study was to reveal possible interconnection between prolongated inflammation and the development or exacerbation of long-term cardiovascular complications after COVID-19. We investigated correlations between humoral and cellular immune system markers together with markers of cardiovascular inflammation/ dysfunction during COVID-19 onset and subsequent recovery. We analyzed 22 hospitalized patients with severe COVID-19 within three timepoints (acute, 1 and 6 months after COVID-19) in order to track the impact of COVID-19 on the long-term decline of the cardiovascular system fitness and eventual development of CVDs. Among the cytokines dysregulated during COVID-19 changes, we showed significant correlations of IL-18 as a key driver of several pathophysiological changes with markers of cardiovascular inflammation/dysfunction. Our findings established novel immune-related markers, which can be used for the stratification of patients at high risk of CVDs for further therapy.

Návaznosti

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

Přiložené soubory

Persisting_IL-18_levels_after_COVID-19_correlate_with_markers_of_cardiovascular_inflammation_reflecting_potential_risk_of_CVDs_development.pdf

Citovat

ANDREJČINOVÁ, Ivana; Gabriela BLAZKOVA; Ioanna PAPATHEODOROU; Kamila BENDÍČKOVÁ; Veronika BOSÁKOVÁ; Monika SKOTAKOVA; Roman PANOVSKÝ; Lukáš OPATŘIL; Ondřej VYMAZAL; Petra KOVAČOVICOVÁ; Vladimír ŠRÁMEK; Martin HELÁN; Marcela HORTOVÁ KOHOUTKOVÁ a Jan FRIČ. Persisting IL-18 levels after COVID-19 correlate with markers of cardiovascular inflammation reflecting potential risk of CVDs development. Heliyon. OXFORD: ELSEVIER SCI LTD, 2024, roč. 10, č. 4, s. 1-13. ISSN 2405-8440. Dostupné z: https://doi.org/10.1016/j.heliyon.2024.e25938.

@article{2398757,
   author = {Andrejčinová, Ivana and Blazkova, Gabriela and Papatheodorou, Ioanna and Bendíčková, Kamila and Bosáková, Veronika and Skotakova, Monika and Panovský, Roman and Opatřil, Lukáš and Vymazal, Ondřej and Kovačovicová, Petra and Šrámek, Vladimír and Helán, Martin and Hortová Kohoutková, Marcela and Frič, Jan},
   article_location = {OXFORD},
   article_number = {4},
   doi = {https://doi.org/10.1016/j.heliyon.2024.e25938},
   keywords = {COVID-19; Inflammation; CVDs; COVID-19 long-term consequences; IL-18},
   language = {eng},
   issn = {2405-8440},
   journal = {Heliyon},
   title = {Persisting IL-18 levels after COVID-19 correlate with markers of cardiovascular inflammation reflecting potential risk of CVDs development},
   url = {https://www.sciencedirect.com/science/article/pii/S2405844024019698?via%3Dihub},
   volume = {10},
   year = {2024}
}

TY  - JOUR
ID  - 2398757
AU  - Andrejčinová, Ivana - Blazkova, Gabriela - Papatheodorou, Ioanna - Bendíčková, Kamila - Bosáková, Veronika - Skotakova, Monika - Panovský, Roman - Opatřil, Lukáš - Vymazal, Ondřej - Kovačovicová, Petra - Šrámek, Vladimír - Helán, Martin - Hortová Kohoutková, Marcela - Frič, Jan
PY  - 2024
TI  - Persisting IL-18 levels after COVID-19 correlate with markers of cardiovascular inflammation reflecting potential risk of CVDs development
JF  - Heliyon
VL  - 10
IS  - 4
SP  - 1-13
EP  - 1-13
PB  - ELSEVIER SCI LTD
SN  - 24058440
KW  - COVID-19
KW  - Inflammation
KW  - CVDs
KW  - COVID-19 long-term consequences
KW  - IL-18
UR  - https://www.sciencedirect.com/science/article/pii/S2405844024019698?via%3Dihub
N2  - COVID-19 manifestation is associated with a strong immune system activation leading to inflammation and subsequently affecting the cardiovascular system. The objective of the study was to reveal possible interconnection between prolongated inflammation and the development or exacerbation of long-term cardiovascular complications after COVID-19. We investigated correlations between humoral and cellular immune system markers together with markers of cardiovascular inflammation/ dysfunction during COVID-19 onset and subsequent recovery. We analyzed 22 hospitalized patients with severe COVID-19 within three timepoints (acute, 1 and 6 months after COVID-19) in order to track the impact of COVID-19 on the long-term decline of the cardiovascular system fitness and eventual development of CVDs. Among the cytokines dysregulated during COVID-19 changes, we showed significant correlations of IL-18 as a key driver of several pathophysiological changes with markers of cardiovascular inflammation/dysfunction. Our findings established novel immune-related markers, which can be used for the stratification of patients at high risk of CVDs for further therapy.
ER  -

ANDREJČINOVÁ, Ivana; Gabriela BLAZKOVA; Ioanna PAPATHEODOROU; Kamila BENDÍČKOVÁ; Veronika BOSÁKOVÁ; Monika SKOTAKOVA; Roman PANOVSKÝ; Lukáš OPATŘIL; Ondřej VYMAZAL; Petra KOVAČOVICOVÁ; Vladimír ŠRÁMEK; Martin HELÁN; Marcela HORTOVÁ KOHOUTKOVÁ a Jan FRIČ. Persisting IL-18 levels after COVID-19 correlate with markers of cardiovascular inflammation reflecting potential risk of CVDs development. \textit{Heliyon}. OXFORD: ELSEVIER SCI LTD, 2024, roč.~10, č.~4, s.~1-13. ISSN~2405-8440. Dostupné z: https://doi.org/10.1016/j.heliyon.2024.e25938.

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