Triphenyltin isoselenocyanate: a novel nuclear retinoid X
receptor ligand with antiproliferative and cytotoxic properties
in cell lines derived from human breast cancer

J 2024

Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer

MACEJOVA, Dana; Jakub KOLLAR; Pavel BOBÁĽ; Jan OTEVŘEL; Daniela SCHUSTER et al.

Základní údaje

Originální název

Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer

Autoři

MACEJOVA, Dana; Jakub KOLLAR; Pavel BOBÁĽ; Jan OTEVŘEL; Daniela SCHUSTER a Julius BRTKO

Vydání

Molecular and Cellular Biochemistry, DORDRECHT, Springer, 2024, 0300-8177

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/24:00135990

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Triorganotin isoselenocyanates; Retinoid X receptor; Apoptosis; Breast cancer

Štítky

rivok, ÚChL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2026 15:48, Mgr. Irena Doubková

Anotace

V originále

Several commercially available triorganotin compounds were previously found to function as agonist ligands for nuclear retinoid X receptor (RXR) molecules. Triphenyltin isoselenocyanate (TPT-NCSe), a novel selenium atom containing a derivative of triorganotin origin, was found to represent a new cognate bioactive ligand for RXRs. TPT-NCSe displayed a concentration- and time-dependent decrease in the cell viability in both human breast carcinoma MCF-7 (estrogen receptor positive) and MDA-MB-231 (triple negative) cell lines. Reactive oxygen species levels generated in response to TPT-NCSe were significantly higher in both carcinoma cell lines treated with TPT-NCSe when compared to mock-treated samples. Treatment with 500 nM TPT-NCSe caused a decrease in SOD1 and increased SOD2 mRNA in MCF-7 cells. The levels of SOD2 mRNA were more increased following the treatment with TPT-NCSe along with 1 mu M all-trans retinoic acid (AtRA) in MCF-7 cells. An increased superoxide dismutase SOD1 and SOD2 mRNA levels were also detected in combination treatment of 500 nM TPT-NCSe and 1 mu M AtRA in TPT-NCSe-treated MDA-MB-231 cells. The data have also shown that TPT-NCSe induces apoptosis via a caspase cascade triggered by the mitochondrial apoptotic pathway. TPT-NCSe modulates the expression levels of apoptosis-related proteins, Annexin A5, Bcl-2 and BAX family proteins, and finally, it enhances the expression levels of its cognate nuclear receptor subtypes RXRalpha and RXRbeta.

Citovat

MACEJOVA, Dana; Jakub KOLLAR; Pavel BOBÁĽ; Jan OTEVŘEL; Daniela SCHUSTER a Julius BRTKO. Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer. Molecular and Cellular Biochemistry. DORDRECHT: Springer, 2024, roč. 479, č. 11, s. 3091-3106. ISSN 0300-8177. Dostupné z: https://doi.org/10.1007/s11010-023-04914-w.

@article{2401320,
   author = {Macejova, Dana and Kollar, Jakub and Bobáľ, Pavel and Otevřel, Jan and Schuster, Daniela and Brtko, Julius},
   article_location = {DORDRECHT},
   article_number = {11},
   doi = {https://doi.org/10.1007/s11010-023-04914-w},
   keywords = {Triorganotin isoselenocyanates; Retinoid X receptor; Apoptosis; Breast cancer},
   language = {eng},
   issn = {0300-8177},
   journal = {Molecular and Cellular Biochemistry},
   title = {Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer},
   url = {https://link.springer.com/content/pdf/10.1007/s11010-023-04914-w.pdf},
   volume = {479},
   year = {2024}
}

TY  - JOUR
ID  - 2401320
AU  - Macejova, Dana - Kollar, Jakub - Bobáľ, Pavel - Otevřel, Jan - Schuster, Daniela - Brtko, Julius
PY  - 2024
TI  - Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer
JF  - Molecular and Cellular Biochemistry
VL  - 479
IS  - 11
SP  - 3091-3106
EP  - 3091-3106
PB  - Springer
SN  - 03008177
KW  - Triorganotin isoselenocyanates
KW  - Retinoid X receptor
KW  - Apoptosis
KW  - Breast cancer
UR  - https://link.springer.com/content/pdf/10.1007/s11010-023-04914-w.pdf
N2  - Several commercially available triorganotin compounds were previously found to function as agonist ligands for nuclear retinoid X receptor (RXR) molecules. Triphenyltin isoselenocyanate (TPT-NCSe), a novel selenium atom containing a derivative of triorganotin origin, was found to represent a new cognate bioactive ligand for RXRs. TPT-NCSe displayed a concentration- and time-dependent decrease in the cell viability in both human breast carcinoma MCF-7 (estrogen receptor positive) and MDA-MB-231 (triple negative) cell lines. Reactive oxygen species levels generated in response to TPT-NCSe were significantly higher in both carcinoma cell lines treated with TPT-NCSe when compared to mock-treated samples. Treatment with 500 nM TPT-NCSe caused a decrease in SOD1 and increased SOD2 mRNA in MCF-7 cells. The levels of SOD2 mRNA were more increased following the treatment with TPT-NCSe along with 1 mu M all-trans retinoic acid (AtRA) in MCF-7 cells. An increased superoxide dismutase SOD1 and SOD2 mRNA levels were also detected in combination treatment of 500 nM TPT-NCSe and 1 mu M AtRA in TPT-NCSe-treated MDA-MB-231 cells. The data have also shown that TPT-NCSe induces apoptosis via a caspase cascade triggered by the mitochondrial apoptotic pathway. TPT-NCSe modulates the expression levels of apoptosis-related proteins, Annexin A5, Bcl-2 and BAX family proteins, and finally, it enhances the expression levels of its cognate nuclear receptor subtypes RXRalpha and RXRbeta.
ER  -

MACEJOVA, Dana; Jakub KOLLAR; Pavel BOBÁĽ; Jan OTEVŘEL; Daniela SCHUSTER a Julius BRTKO. Triphenyltin isoselenocyanate: a novel nuclear retinoid X receptor ligand with antiproliferative and cytotoxic properties in cell lines derived from human breast cancer. \textit{Molecular and Cellular Biochemistry}. DORDRECHT: Springer, 2024, roč.~479, č.~11, s.~3091-3106. ISSN~0300-8177. Dostupné z: https://doi.org/10.1007/s11010-023-04914-w.

Přehled o publikaci