Coinfection of a yaws patient with two closely related
Treponema pallidum subsp. pertenue strains: A rare event with
potential evolutionary implications

J 2024

Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications

MEDAPPA, Monica; Petra POSPÍŠILOVÁ; Lucy N JOHN; Camila GONZÁLEZ-BEIRAS; Oriol MITJÀ et al.

Základní údaje

Originální název

Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications

Autoři

MEDAPPA, Monica; Petra POSPÍŠILOVÁ; Lucy N JOHN; Camila GONZÁLEZ-BEIRAS; Oriol MITJÀ a David ŠMAJS

Vydání

Acta Tropica, AMSTERDAM, ELSEVIER, 2024, 0001-706X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10607 Virology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.500

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00136079

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Treponema pallidum subsp. pertenue (TPE); Yaws; Coinfection; Inter-strain recombination; TPE allelic profiles; PCR chimeric clones

Štítky

14110513, NIVB_LF, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 1. 2025 10:00, Mgr. Tereza Miškechová

Anotace

V originále

The etiological agent of yaws is the spirochete Treponema pallidum (TP) subsp. pertenue (TPE) and infects the children of Papua New Guinea, causing ulcerative skin lesions that impairs normal growth and development. Closely related strains of Treponema pallidum subsp. pertenue, JE11, and TE13 were detected in an ulcer biospecimen derived from a 5-year-old yaws patient. Cloning experiments validated the presence of two distinct but similar genotypes, namely TE13 and JE11, co-occurring within a single host. While coinfection with highly related TPE strains has only limited epidemiological and clinical relevance, this is the first documented coinfection with genetically distinct TP strains in a single patient. Similar coinfections in the past were explained by the existence of over a dozen recombinant loci present in the TP genomes as a result of inter-strain or inter-subspecies recombination events following an anticipated scenario of TP coinfection, i.e., uptake of foreign DNA and DNA recombination.

Návaznosti

LX22NPO5103, projekt VaV

Název: Národní institut virologie a bakteriologie (Akronym: NIVB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut virologie a bakteriologie, 5.1 EXCELES

MUNI/A/1603/2023, interní kód MU

Název: Biomedicínské vědy IV

Investor: Masarykova univerzita, Biomedicínské vědy IV

Přiložené soubory

Coinfection_of_a_yaws_patient_with_two_closely_related_Treponema_pallidum_subsp._pertenue_strains_A_rare_event_with_potential_evolutionary_implications.pdf

Citovat

MEDAPPA, Monica; Petra POSPÍŠILOVÁ; Lucy N JOHN; Camila GONZÁLEZ-BEIRAS; Oriol MITJÀ a David ŠMAJS. Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications. Acta Tropica. AMSTERDAM: ELSEVIER, 2024, roč. 256, August 2024, s. 1-6. ISSN 0001-706X. Dostupné z: https://doi.org/10.1016/j.actatropica.2024.107254.

@article{2405658,
   author = {Medappa, Monica and Pospíšilová, Petra and John, Lucy N and GonzálezandBeiras, Camila and Mitjà, Oriol and Šmajs, David},
   article_location = {AMSTERDAM},
   article_number = {August 2024},
   doi = {https://doi.org/10.1016/j.actatropica.2024.107254},
   keywords = {Treponema pallidum subsp. pertenue (TPE); Yaws; Coinfection; Inter-strain recombination; TPE allelic profiles; PCR chimeric clones},
   language = {eng},
   issn = {0001-706X},
   journal = {Acta Tropica},
   title = {Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications},
   url = {https://www.sciencedirect.com/science/article/pii/S0001706X24001360?via%3Dihub},
   volume = {256},
   year = {2024}
}

TY  - JOUR
ID  - 2405658
AU  - Medappa, Monica - Pospíšilová, Petra - John, Lucy N - González-Beiras, Camila - Mitjà, Oriol - Šmajs, David
PY  - 2024
TI  - Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications
JF  - Acta Tropica
VL  - 256
IS  - August 2024
SP  - 1-6
EP  - 1-6
PB  - ELSEVIER
SN  - 0001706X
KW  - Treponema pallidum subsp. pertenue (TPE)
KW  - Yaws
KW  - Coinfection
KW  - Inter-strain recombination
KW  - TPE allelic profiles
KW  - PCR chimeric clones
UR  - https://www.sciencedirect.com/science/article/pii/S0001706X24001360?via%3Dihub
N2  - The etiological agent of yaws is the spirochete Treponema pallidum (TP) subsp. pertenue (TPE) and infects the children of Papua New Guinea, causing ulcerative skin lesions that impairs normal growth and development. Closely related strains of Treponema pallidum subsp. pertenue, JE11, and TE13 were detected in an ulcer biospecimen derived from a 5-year-old yaws patient. Cloning experiments validated the presence of two distinct but similar genotypes, namely TE13 and JE11, co-occurring within a single host. While coinfection with highly related TPE strains has only limited epidemiological and clinical relevance, this is the first documented coinfection with genetically distinct TP strains in a single patient. Similar coinfections in the past were explained by the existence of over a dozen recombinant loci present in the TP genomes as a result of inter-strain or inter-subspecies recombination events following an anticipated scenario of TP coinfection, i.e., uptake of foreign DNA and DNA recombination.
ER  -

MEDAPPA, Monica; Petra POSPÍŠILOVÁ; Lucy N JOHN; Camila GONZÁLEZ-BEIRAS; Oriol MITJÀ a David ŠMAJS. Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications. \textit{Acta Tropica}. AMSTERDAM: ELSEVIER, 2024, roč.~256, August 2024, s.~1-6. ISSN~0001-706X. Dostupné z: https://doi.org/10.1016/j.actatropica.2024.107254.

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