Anticholinesterase Activity of Methanolic Extract of Amorpha
fruticosa Flowers and Isolation of Rotenoids and Putrescine and
Spermidine Derivatives

J 2024

Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

JANKOVSKÁ, Dagmar; Nikol JURČOVÁ; Renata KUBÍNOVÁ; Jiří VÁCLAVÍK; Emil ŠVAJDLENKA et al.

Základní údaje

Originální název

Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

Autoři

JANKOVSKÁ, Dagmar ; Nikol JURČOVÁ; Renata KUBÍNOVÁ; Jiří VÁCLAVÍK; Emil ŠVAJDLENKA; Anna MASCELLANI; Petr MARSIK; Kateřina BOUZKOVÁ a Milan MALANÍK

Vydání

PLANTS-BASEL, BASEL, MDPI, 2024, 2223-7747

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10611 Plant sciences, botany

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/24:00136085

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine

Štítky

CF NMR, rivok, ÚPL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 3. 2025 14:00, Mgr. Eva Dubská

Anotace

V originále

Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.

Návaznosti

EF18_046/0015974, projekt VaV

Název: Modernizace České infrastruktury pro integrativní strukturní biologii

90242, velká výzkumná infrastruktura

Název: CIISB III

Citovat

JANKOVSKÁ, Dagmar; Nikol JURČOVÁ; Renata KUBÍNOVÁ; Jiří VÁCLAVÍK; Emil ŠVAJDLENKA; Anna MASCELLANI; Petr MARSIK; Kateřina BOUZKOVÁ a Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. PLANTS-BASEL. BASEL: MDPI, 2024, roč. 13, č. 9, s. 1-10. ISSN 2223-7747. Dostupné z: https://doi.org/10.3390/plants13091181.

@article{2405907,
   author = {Jankovská, Dagmar and Jurčová, Nikol and Kubínová, Renata and Václavík, Jiří and Švajdlenka, Emil and Mascellani, Anna and Marsik, Petr and Bouzková, Kateřina and Malaník, Milan},
   article_location = {BASEL},
   article_number = {9},
   doi = {https://doi.org/10.3390/plants13091181},
   keywords = {AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine},
   language = {eng},
   issn = {2223-7747},
   journal = {PLANTS-BASEL},
   title = {Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives},
   url = {https://pubmed.ncbi.nlm.nih.gov/38732396/},
   volume = {13},
   year = {2024}
}

TY  - JOUR
ID  - 2405907
AU  - Jankovská, Dagmar - Jurčová, Nikol - Kubínová, Renata - Václavík, Jiří - Švajdlenka, Emil - Mascellani, Anna - Marsik, Petr - Bouzková, Kateřina - Malaník, Milan
PY  - 2024
TI  - Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives
JF  - PLANTS-BASEL
VL  - 13
IS  - 9
SP  - 1-10
EP  - 1-10
PB  - MDPI
SN  - 22237747
KW  - AChE
KW  - Amorpha fruticosa
KW  - BuChE
KW  - molecular docking
KW  - putrescine
KW  - spermidine
UR  - https://pubmed.ncbi.nlm.nih.gov/38732396/
N2  - Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
ER  -

JANKOVSKÁ, Dagmar; Nikol JURČOVÁ; Renata KUBÍNOVÁ; Jiří VÁCLAVÍK; Emil ŠVAJDLENKA; Anna MASCELLANI; Petr MARSIK; Kateřina BOUZKOVÁ a Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. \textit{PLANTS-BASEL}. BASEL: MDPI, 2024, roč.~13, č.~9, s.~1-10. ISSN~2223-7747. Dostupné z: https://doi.org/10.3390/plants13091181.

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