Anticholinesterase Activity of Methanolic Extract of Amorpha
fruticosa Flowers and Isolation of Rotenoids and Putrescine and
Spermidine Derivatives

J 2024

Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA et. al.

Základní údaje

Originální název

Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

Autoři

JANKOVSKÁ, Dagmar (203 Česká republika, domácí), Nikol JURČOVÁ (203 Česká republika, domácí), Renata KUBÍNOVÁ (203 Česká republika, domácí), Jiří VÁCLAVÍK (203 Česká republika, domácí), Emil ŠVAJDLENKA (203 Česká republika, domácí), Anna MASCELLANI, Petr MARSIK (203 Česká republika), Kateřina BOUZKOVÁ (203 Česká republika) a Milan MALANÍK (203 Česká republika, domácí)

Vydání

PLANTS-BASEL, BASEL, MDPI, 2024, 2223-7747

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10611 Plant sciences, botany

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.500 v roce 2022

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/plants13091181

UT WoS

001220531500001

Klíčová slova anglicky

AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine

Štítky

ÚPL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 5. 2024 10:02, PharmDr. Milan Malaník, Ph.D.

Anotace

V originále

Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.

Návaznosti

EF18_046/0015974, projekt VaV

Název: Modernizace České infrastruktury pro integrativní strukturní biologii

LM2023042, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CIISB - Česká infrastruktura pro integrativní strukturní biologii

Citovat

JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ a Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. PLANTS-BASEL. BASEL: MDPI, 2024, roč. 13, č. 9, s. Neuvedeno, 10 s. ISSN 2223-7747. Dostupné z: https://dx.doi.org/10.3390/plants13091181.

@article{2405907,
   author = {Jankovská, Dagmar and Jurčová, Nikol and Kubínová, Renata and Václavík, Jiří and Švajdlenka, Emil and Mascellani, Anna and Marsik, Petr and Bouzková, Kateřina and Malaník, Milan},
   article_location = {BASEL},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/plants13091181},
   keywords = {AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine},
   language = {eng},
   issn = {2223-7747},
   journal = {PLANTS-BASEL},
   title = {Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives},
   url = {https://pubmed.ncbi.nlm.nih.gov/38732396/},
   volume = {13},
   year = {2024}
}

TY  - JOUR
ID  - 2405907
AU  - Jankovská, Dagmar - Jurčová, Nikol - Kubínová, Renata - Václavík, Jiří - Švajdlenka, Emil - Mascellani, Anna - Marsik, Petr - Bouzková, Kateřina - Malaník, Milan
PY  - 2024
TI  - Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives
JF  - PLANTS-BASEL
VL  - 13
IS  - 9
SP  - Neuvedeno
EP  - Neuvedeno
PB  - MDPI
SN  - 22237747
KW  - AChE
KW  - Amorpha fruticosa
KW  - BuChE
KW  - molecular docking
KW  - putrescine
KW  - spermidine
UR  - https://pubmed.ncbi.nlm.nih.gov/38732396/
N2  - Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
ER  -

JANKOVSKÁ, Dagmar, Nikol JURČOVÁ, Renata KUBÍNOVÁ, Jiří VÁCLAVÍK, Emil ŠVAJDLENKA, Anna MASCELLANI, Petr MARSIK, Kateřina BOUZKOVÁ a Milan MALANÍK. Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives. \textit{PLANTS-BASEL}. BASEL: MDPI, 2024, roč.~13, č.~9, s.~Neuvedeno, 10 s. ISSN~2223-7747. Dostupné z: https://dx.doi.org/10.3390/plants13091181.

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