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@article{2407562,
author = {Apostolopoulos, Vasileios and Bohac, Petr and Marcian, Petr and Zambo, Iva and Pazourek, Lukáš and Mahdal, Michal and Neradil, Jakub and Navrat, Tomas and Tomáš, Tomáš},
article_location = {New York},
doi = {http://dx.doi.org/10.1245/s10434-024-15397-4},
keywords = {Local adjuvants; Giant cell tumor of bone; Micro-CT; Bone hardness; Bone necrosis},
language = {eng},
issn = {1068-9265},
journal = {Annals of Surgical Oncology},
title = {Micro-CT, Mechanical, and Histological Examination of the Effect of Local Adjuvants on Porcine Cortical Bone Following Intralesional Curettage of Bone Tumors},
url = {https://link.springer.com/article/10.1245/s10434-024-15397-4},
year = {2024}
}
TY - JOUR
ID - 2407562
AU - Apostolopoulos, Vasileios - Bohac, Petr - Marcian, Petr - Zambo, Iva - Pazourek, Lukáš - Mahdal, Michal - Neradil, Jakub - Navrat, Tomas - Tomáš, Tomáš
PY - 2024
TI - Micro-CT, Mechanical, and Histological Examination of the Effect of Local Adjuvants on Porcine Cortical Bone Following Intralesional Curettage of Bone Tumors
JF - Annals of Surgical Oncology
PB - Springer
SN - 10689265
KW - Local adjuvants
KW - Giant cell tumor of bone
KW - Micro-CT
KW - Bone hardness
KW - Bone necrosis
UR - https://link.springer.com/article/10.1245/s10434-024-15397-4
N2 - Background and Objectives Curettage is the removal of a tumor from the bone while preserving the surrounding healthy cortical bone, and is associated with higher rates of local recurrence. To lower these rates, curettage should be combined with local adjuvants, although their use is associated with damage to nearby healthy bone.Objective The purpose of this analysis is to determine the effect of local adjuvants on cortical porcine bone by using micro-computed tomography (micro-CT) along with histological and mechanical examination.Methods Local adjuvants were applied to porcine specimens under defined conditions. To assess changes in bone mineral density (BMD), a micro-CT scan was used. The pixel gray values of the volume of interest (VOI) were evaluated per specimen and converted to BMD values. The Vickers hardness test was employed to assess bone hardness (HV). The depth of necrosis was measured histologically using hematoxylin and eosin-stained tissue sections.Results A noticeable change in BMD was observed on the argon beam coagulation (ABC) sample. Comparable hardness values were measured on samples following electrocautery and ABC, and lowering of bone hardness was obtained in the case of liquid nitrogen. Extensive induced depth of necrosis was registered in the specimen treated with liquid nitrogen.Conclusion This study determined the effect of local adjuvants on cortical bone by using micro-CT along with histological and mechanical examination. Phenolization and liquid nitrogen application caused a decrease in bone hardness. The bone density was affected in the range of single-digit percentage values. Liquid nitrogen induced extensive depth of necrosis with a wide variance of values.
ER -
APOSTOLOPOULOS, Vasileios, Petr BOHAC, Petr MARCIAN, Iva ZAMBO, Lukáš PAZOUREK, Michal MAHDAL, Jakub NERADIL, Tomas NAVRAT a Tomáš TOMÁŠ. Micro-CT, Mechanical, and Histological Examination of the Effect of Local Adjuvants on Porcine Cortical Bone Following Intralesional Curettage of Bone Tumors. \textit{Annals of Surgical Oncology}. New York: Springer, 2024, 9 s. ISSN~1068-9265. Dostupné z: https://dx.doi.org/10.1245/s10434-024-15397-4.
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