Enhancing the utility of chromosome 6 and 8 testing in uveal
melanoma biopsies

J 2025

Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies

MATUŠKOVÁ, Veronika; Pavla HORŇÁČKOVÁ; Marek MICHALEC; Lenka ZLÁMALÍKOVÁ; Květoslava MATULOVÁ et al.

Základní údaje

Originální název

Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies

Autoři

MATUŠKOVÁ, Veronika ; Pavla HORŇÁČKOVÁ; Marek MICHALEC; Lenka ZLÁMALÍKOVÁ; Květoslava MATULOVÁ a Michal UHER

Vydání

Biomedical Papers, OLOMOUC, PALACKY UNIV, MEDICAL FAC, 2025, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30207 Ophthalmology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.700 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140241

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

uveal melanoma; chromosome 6; chromosome 8; CISH; FISH; progression free survival

Štítky

14110219, 14110230, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 2. 2026 13:15, Mgr. Tereza Miškechová

Anotace

V originále

Background: The aim of this study was to evaluate the significance of testing the gain of chromosome 8 and the gain of chromosome 6 as prognostic markers in histopathological samples of enucleated eyes in with uveal melanoma. Methods: This is a retrospective study of 54 enucleated eyes. The status of chromosomes 3, 8 and 6 was tested by CISH, and FISH was used in a few samples. A follow-up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was determined. Results: The study group consists of 54 patients (average age 63 years), 28 men (51.9%) Monosomy 3 together with gain of chromosome 8 was found in 10 samples (18.5%). Both chromosomal abnormalities were detected in 6 (11%) patients. No chromosomal abnormality in 3 or 8 was detected in 21 (38.9%) patients. Abnormalities of chromosome 6 were present in 6 (11%) patients. Progression free survival after 5 years was 33.3% (95% CI 0.0; 83.3) in these patients. Conclusions: Our findings indicate a correlation between progression-free survival and the presence of changes in chromosome 3 and e 8 in uveal melanomas. The results underline the necessity of testing for both chromosomal aberrations.

Citovat

MATUŠKOVÁ, Veronika; Pavla HORŇÁČKOVÁ; Marek MICHALEC; Lenka ZLÁMALÍKOVÁ; Květoslava MATULOVÁ a Michal UHER. Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies. Biomedical Papers. OLOMOUC: PALACKY UNIV, MEDICAL FAC, 2025, roč. 169, č. 3, s. 196-202. ISSN 1213-8118. Dostupné z: https://doi.org/10.5507/bp.2024.018.

@article{2407838,
   author = {Matušková, Veronika and Horňáčková, Pavla and Michalec, Marek and Zlámalíková, Lenka and Matulová, Květoslava and Uher, Michal},
   article_location = {OLOMOUC},
   article_number = {3},
   doi = {https://doi.org/10.5507/bp.2024.018},
   keywords = {uveal melanoma; chromosome 6; chromosome 8; CISH; FISH; progression free survival},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3672},
   volume = {169},
   year = {2025}
}

TY  - JOUR
ID  - 2407838
AU  - Matušková, Veronika - Horňáčková, Pavla - Michalec, Marek - Zlámalíková, Lenka - Matulová, Květoslava - Uher, Michal
PY  - 2025
TI  - Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies
JF  - Biomedical Papers
VL  - 169
IS  - 3
SP  - 196-202
EP  - 196-202
PB  - PALACKY UNIV, MEDICAL FAC
SN  - 12138118
KW  - uveal melanoma
KW  - chromosome 6
KW  - chromosome 8
KW  - CISH
KW  - FISH
KW  - progression free survival
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3672
N2  - Background: The aim of this study was to evaluate the significance of testing the gain of chromosome 8 and the gain of chromosome 6 as prognostic markers in histopathological samples of enucleated eyes in with uveal melanoma. Methods: This is a retrospective study of 54 enucleated eyes. The status of chromosomes 3, 8 and 6 was tested by CISH, and FISH was used in a few samples. A follow-up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was determined. Results: The study group consists of 54 patients (average age 63 years), 28 men (51.9%) Monosomy 3 together with gain of chromosome 8 was found in 10 samples (18.5%). Both chromosomal abnormalities were detected in 6 (11%) patients. No chromosomal abnormality in 3 or 8 was detected in 21 (38.9%) patients. Abnormalities of chromosome 6 were present in 6 (11%) patients. Progression free survival after 5 years was 33.3% (95% CI 0.0; 83.3) in these patients. Conclusions: Our findings indicate a correlation between progression-free survival and the presence of changes in chromosome 3 and e 8 in uveal melanomas. The results underline the necessity of testing for both chromosomal aberrations.
ER  -

MATUŠKOVÁ, Veronika; Pavla HORŇÁČKOVÁ; Marek MICHALEC; Lenka ZLÁMALÍKOVÁ; Květoslava MATULOVÁ a Michal UHER. Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies. \textit{Biomedical Papers}. OLOMOUC: PALACKY UNIV, MEDICAL FAC, 2025, roč.~169, č.~3, s.~196-202. ISSN~1213-8118. Dostupné z: https://doi.org/10.5507/bp.2024.018.

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