A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO)
Gene Is Associated with Sepsis Status in Children

J 2024

A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children

JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ et. al.

Základní údaje

Originální název

A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children

Autoři

JABANDŽIEV, Petr (203 Česká republika, domácí), Jaroslav Alois HUBACEK (203 Česká republika), Michalek JAROSLAV (203 Česká republika), Martin JOUZA (203 Česká republika, domácí), Jan PAPEŽ (203 Česká republika, domácí), Jakub PECL (203 Česká republika, domácí), Kateřina SLABÁ (203 Česká republika, domácí), Ondřej SLABÝ (203 Česká republika, domácí), Milan URÍK (703 Slovensko, domácí), Štefánia AULICKÁ (703 Slovensko, domácí), Lumír KUNOVSKÝ (203 Česká republika), Michalek JAROSLAV (203 Česká republika), Petr DOMINIK (203 Česká republika, domácí), Milan KRATOCHVÍL (703 Slovensko, domácí), Jozef KLUČKA (703 Slovensko, domácí) a Petr ŠTOURAČ (203 Česká republika, domácí)

Vydání

ROMANIAN JOURNAL OF INTERNAL MEDICINE, WARSAW, SCIENDO, 2024, 1582-3296

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.900 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2478/rjim-2024-0008

UT WoS

001181323600001

Klíčová slova anglicky

child; obesity; sepsis; genotype; genetic predisposition to the disease

Štítky

14110317, 14110319, 14110320, 14110322, 14110513

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 10. 2024 14:57, Mgr. Tereza Miškechová

Anotace

V originále

Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents. Methods We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults. Results We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39-0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62-1.06). Conclusions Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.

Citovat

JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ, Jakub PECL, Kateřina SLABÁ, Ondřej SLABÝ, Milan URÍK, Štefánia AULICKÁ, Lumír KUNOVSKÝ, Michalek JAROSLAV, Petr DOMINIK, Milan KRATOCHVÍL, Jozef KLUČKA a Petr ŠTOURAČ. A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children. ROMANIAN JOURNAL OF INTERNAL MEDICINE. WARSAW: SCIENDO, 2024, roč. 62, č. 3, s. 279-285, 18 s. ISSN 1582-3296. Dostupné z: https://dx.doi.org/10.2478/rjim-2024-0008.

@article{2407859,
   author = {Jabandžiev, Petr and Hubacek, Jaroslav Alois and Jaroslav, Michalek and Jouza, Martin and Papež, Jan and Pecl, Jakub and Slabá, Kateřina and Slabý, Ondřej and Urík, Milan and Aulická, Štefánia and Kunovský, Lumír and Jaroslav, Michalek and Dominik, Petr and Kratochvíl, Milan and Klučka, Jozef and Štourač, Petr},
   article_location = {WARSAW},
   article_number = {3},
   doi = {http://dx.doi.org/10.2478/rjim-2024-0008},
   keywords = {child; obesity; sepsis; genotype; genetic predisposition to the disease},
   language = {eng},
   issn = {1582-3296},
   journal = {ROMANIAN JOURNAL OF INTERNAL MEDICINE},
   title = {A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children},
   url = {https://sciendo.com/article/10.2478/rjim-2024-0008},
   volume = {62},
   year = {2024}
}

TY  - JOUR
ID  - 2407859
AU  - Jabandžiev, Petr - Hubacek, Jaroslav Alois - Jaroslav, Michalek - Jouza, Martin - Papež, Jan - Pecl, Jakub - Slabá, Kateřina - Slabý, Ondřej - Urík, Milan - Aulická, Štefánia - Kunovský, Lumír - Jaroslav, Michalek - Dominik, Petr - Kratochvíl, Milan - Klučka, Jozef - Štourač, Petr
PY  - 2024
TI  - A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children
JF  - ROMANIAN JOURNAL OF INTERNAL MEDICINE
VL  - 62
IS  - 3
SP  - 279-285
EP  - 279-285
PB  - SCIENDO
SN  - 15823296
KW  - child
KW  - obesity
KW  - sepsis
KW  - genotype
KW  - genetic predisposition to the disease
UR  - https://sciendo.com/article/10.2478/rjim-2024-0008
N2  - Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents. Methods We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults. Results We observed a lower prevalence (p < 0.01; OR = 0.59, 95% CI = 0.39-0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p < 0.09, OR = 0.81, 95% CI = 0.62-1.06). Conclusions Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.
ER  -

JABANDŽIEV, Petr, Jaroslav Alois HUBACEK, Michalek JAROSLAV, Martin JOUZA, Jan PAPEŽ, Jakub PECL, Kateřina SLABÁ, Ondřej SLABÝ, Milan URÍK, Štefánia AULICKÁ, Lumír KUNOVSKÝ, Michalek JAROSLAV, Petr DOMINIK, Milan KRATOCHVÍL, Jozef KLUČKA a Petr ŠTOURAČ. A Tagging Polymorphism in Fat Mass and Obesity-Associated (FTO) Gene Is Associated with Sepsis Status in Children. \textit{ROMANIAN JOURNAL OF INTERNAL MEDICINE}. WARSAW: SCIENDO, 2024, roč.~62, č.~3, s.~279-285, 18 s. ISSN~1582-3296. Dostupné z: https://dx.doi.org/10.2478/rjim-2024-0008.

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