Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice

LAZOVIC, Jelena, Lydia M ZOPF, Jernej HREN, Martin GAJDOŠ, Marija SLAVKOVIC, Zorana JOVIC, Ivana STANKOVIC, Valentina MATOVIC a Djuro KORUGA. Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice. SYMMETRY-BASEL. SWITZERLAND: MDPI, 2021, roč. 13, č. 11, s. 1-14. ISSN 2073-8994. Dostupné z: https://dx.doi.org/10.3390/sym13112004.

Základní údaje

• Originální název: Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
• Autoři: LAZOVIC, Jelena, Lydia M ZOPF, Jernej HREN, Martin GAJDOŠ, Marija SLAVKOVIC, Zorana JOVIC, Ivana STANKOVIC, Valentina MATOVIC a Djuro KORUGA.
• Vydání: SYMMETRY-BASEL, SWITZERLAND, MDPI, 2021, 2073-8994.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 30103 Neurosciences
• Stát vydavatele: Švýcarsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Impakt faktor: Impact factor: 2.940
• Doi: http://dx.doi.org/10.3390/sym13112004
• UT WoS: 000806903700001
• Klíčová slova anglicky: fullerene; fullerenol; fullerenol water complex; emotional processing; anxiety; light spectrum; pain; resting state fMRI; MRI; behavior
• Štítky: CF MAFIL
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

The most symmetric molecule, Buckminster fullerene C-60, due to its unique properties, has been intensively studied for various medical and technological advances. Minimally invasive and minimally toxic treatments hold great promise for future applications. With this in mind, this research exploited the physical properties of fullerene molecules for potential therapeutic effects. Pristine fullerenes have peak absorbance in the 380-500 nm range, making them an attractive violet-blue light filter. Since spectral quality of light can affect behavior, this research used resting state functional magnetic resonance imaging (rs fMRI) and behavioral testing to directly evaluate the effects of fullerene-filtered light on brain processing and behavior in mice. The same method was used to study if hydroxyl fullerene water complexes (3HFWC), with or without fullerene-filtered light, modulated brain processing. A month-long, daily exposure to fullerene-filtered light led to decreased activation of the brain area involved in emotional processing (amygdala). Water supplemented with 3HFWC resulted in an activation of brain areas involved in pain modulation and processing (periaqueductal gray), and decreased latency to first reaction when tested with a hot plate. The combination of fullerene-filtered light with 3HFWC in drinking water led to restored sensitivity to a hot plate and activation of brain areas involved in cognitive functions (prelimbic, anterior cingulate and retrosplenial cortex). These results uncovered the potential of fullerene-filtered light to impact emotional processing and modulate pain perception, indicating its further use in stress and pain management.