Dicobalt(ii) helices kill colon cancer cells via
enantiomer-specific mechanisms; DNA damage or microtubule
disruption

J 2024

Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption

SONG, Hualong; Hana KOSTRHUNOVÁ; Jakub ČERVINKA; Julie MACPHERSON; Jaroslav MALINA et al.

Základní údaje

Originální název

Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption

Autoři

Vydání

Chemical Science, Royal Society of Chemistry, 2024, 2041-6520

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.400

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00136540

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

H2AX PHOSPHORYLATION; METALLOHELICES; COMPLEXES; RECOGNITION; INHIBITION; GAMMA-H2AX; LIGANDS; POTENT; FE

Štítky

14313050, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 1. 2025 14:32, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Highly diastereoselective self-assembly reactions give both enantiomers (Lambda and Delta) of anti-parallel triple-stranded bimetallic Co(ii) and Co(iii) cationic helices, without the need for resolution; the first such reaction for Co. The complexes are water soluble and stable, even in the case of Co(ii). Studies in a range of cancer and healthy cell lines indicate high activity and selectivity, and substantial differences between enantiomers. The oxidation state has little effect, and correspondingly, Co(iii) compounds are reduced to Co(ii) e.g. by glutathione. In HCT116 colon cancer cells the Lambda enantiomer induces dose-dependent G2-M arrest in the cell cycle and disrupts microtubule architectures. This Co(ii) Lambda enantiomer is ca. five times more potent than the isostructural Fe(ii) compound. Since the measured cellular uptakes are similar this implies a higher affinity of the Co system for the intracellular target(s); while the two systems are isostructural they have substantially different charge distributions as shown by calculated hydrophobicity maps. In contrast to the Lambda enantiomer, Delta-Co(ii) induces G1 arrest in HCT116 cells, efficiently inhibits the topoisomerase I-catalyzed relaxation of supercoiled plasmid DNA, and, unlike the isostructural Fe(ii) system, causes DNA damage. It thus seems very likely that redox chemistry plays a role in the latter.

Citovat

SONG, Hualong; Hana KOSTRHUNOVÁ; Jakub ČERVINKA; Julie MACPHERSON; Jaroslav MALINA; Teena RAJAN; Roger PHILLIPS; Miles POSTINGS; Samantha SHEPHERD; Xuejian ZHANG; Viktor BRABEC; Nicola J ROGERS a Peter SCOTT. Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption. Chemical Science. Royal Society of Chemistry, 2024, roč. 15, č. 28, s. 11029-11037. ISSN 2041-6520. Dostupné z: https://doi.org/10.1039/d4sc02541e.

@article{2418723,
   author = {Song, Hualong and Kostrhunová, Hana and Červinka, Jakub and Macpherson, Julie and Malina, Jaroslav and Rajan, Teena and Phillips, Roger and Postings, Miles and Shepherd, Samantha and Zhang, Xuejian and Brabec, Viktor and Rogers, Nicola J and Scott, Peter},
   article_number = {28},
   doi = {https://doi.org/10.1039/d4sc02541e},
   keywords = {H2AX PHOSPHORYLATION; METALLOHELICES; COMPLEXES; RECOGNITION; INHIBITION; GAMMA-H2AX; LIGANDS; POTENT; FE},
   language = {eng},
   issn = {2041-6520},
   journal = {Chemical Science},
   title = {Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption},
   url = {https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc02541e},
   volume = {15},
   year = {2024}
}

TY  - JOUR
ID  - 2418723
AU  - Song, Hualong - Kostrhunová, Hana - Červinka, Jakub - Macpherson, Julie - Malina, Jaroslav - Rajan, Teena - Phillips, Roger - Postings, Miles - Shepherd, Samantha - Zhang, Xuejian - Brabec, Viktor - Rogers, Nicola J - Scott, Peter
PY  - 2024
TI  - Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption
JF  - Chemical Science
VL  - 15
IS  - 28
SP  - 11029-11037
EP  - 11029-11037
PB  - Royal Society of Chemistry
SN  - 20416520
KW  - H2AX PHOSPHORYLATION
KW  - METALLOHELICES
KW  - COMPLEXES
KW  - RECOGNITION
KW  - INHIBITION
KW  - GAMMA-H2AX
KW  - LIGANDS
KW  - POTENT
KW  - FE
UR  - https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc02541e
N2  - Highly diastereoselective self-assembly reactions give both enantiomers (Lambda and Delta) of anti-parallel triple-stranded bimetallic Co(ii) and Co(iii) cationic helices, without the need for resolution; the first such reaction for Co. The complexes are water soluble and stable, even in the case of Co(ii). Studies in a range of cancer and healthy cell lines indicate high activity and selectivity, and substantial differences between enantiomers. The oxidation state has little effect, and correspondingly, Co(iii) compounds are reduced to Co(ii) e.g. by glutathione. In HCT116 colon cancer cells the Lambda enantiomer induces dose-dependent G2-M arrest in the cell cycle and disrupts microtubule architectures. This Co(ii) Lambda enantiomer is ca. five times more potent than the isostructural Fe(ii) compound. Since the measured cellular uptakes are similar this implies a higher affinity of the Co system for the intracellular target(s); while the two systems are isostructural they have substantially different charge distributions as shown by calculated hydrophobicity maps. In contrast to the Lambda enantiomer, Delta-Co(ii) induces G1 arrest in HCT116 cells, efficiently inhibits the topoisomerase I-catalyzed relaxation of supercoiled plasmid DNA, and, unlike the isostructural Fe(ii) system, causes DNA damage. It thus seems very likely that redox chemistry plays a role in the latter.
ER  -

SONG, Hualong; Hana KOSTRHUNOVÁ; Jakub ČERVINKA; Julie MACPHERSON; Jaroslav MALINA; Teena RAJAN; Roger PHILLIPS; Miles POSTINGS; Samantha SHEPHERD; Xuejian ZHANG; Viktor BRABEC; Nicola J ROGERS a Peter SCOTT. Dicobalt(ii) helices kill colon cancer cells via enantiomer-specific mechanisms; DNA damage or microtubule disruption. \textit{Chemical Science}. Royal Society of Chemistry, 2024, roč.~15, č.~28, s.~11029-11037. ISSN~2041-6520. Dostupné z: https://doi.org/10.1039/d4sc02541e.

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