Comprehensive overview of adaptor protein Ruk/CIN85 roles in
cancer

a 2024

Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer

HORAK, Iryna; Tetiana SKATERNA; Olha HUDKOVA; Nely LATYSHKO; Olha KHUDIAKOVA et al.

Základní údaje

Originální název

Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer

Autoři

HORAK, Iryna; Tetiana SKATERNA; Olha HUDKOVA; Nely LATYSHKO; Olha KHUDIAKOVA; Kateryna TOKARCHUK; Iryna KRYSIUK; Teriana KISHKO; Lucia KNOPFOVÁ a Liudmyla DROBOT

Vydání

Current Issues od Biochemistry and Biotechnology 2024, 2024

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10600 1.6 Biological sciences

Stát vydavatele

Ukrajina

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Abstracts in BIOTECHNOLOGIA ACTA, V. 17, No 2, 2024

Označené pro přenos do RIV

Organizační jednotka

Přírodovědecká fakulta

ISSN

DOI

https://doi.org/10.15407/biotech17.02.007

Klíčová slova anglicky

Adaptor protein Ruk/CIN85; breast cancer; lung cancer; osteosarcoma; motility; metastasis; cancer stem cells; drug resistance; cancer cell plasticity

Změněno: 5. 3. 2025 13:29, Iryna Horak, Ph.D.

Anotace

V originále

Using cellular models of breast, lung, and bone cancer, the effects of Ruk/CIN85 on multiple attributes of cancer cell plasticity were investigated. It was demonstrated that overexpression of Ruk/CIN85 resulted in elevated motility in vitro and metastatic potential in vivo, while Ruk/CIN85-knockdown cells are characterized by a lack of migration and metastasis. In addition, a high expression level of Ruk/CIN85 is necessary for the acquisition of resistance to anticancer drugs. Analysis of possible molecular mechanisms revealed expression of EMT- and CSCs-related markers, ECM remodeling ability, as well as metabolic reprogramming (Warburg effect) in Ruk/CIN85-overexpressing cells. On the contrary, Ruk/CIN85 knockdown resulted in the acquisition of a more differentiated phenotype with increased adhesion and proliferation.

Návaznosti

140139, interní kód MU

Název: Adaptor protein Ruk/CIN85 as a potential molecular marker in human osteosarcoma (CIN85OSA)

Investor: Evropská unie, Adaptor protein Ruk/CIN85 as a potential molecular marker in human osteosarcoma (CIN85OSA), Marie Skłodowska-Curie Postdoctoral Fellowships (MSCA PF)

Citovat

HORAK, Iryna; Tetiana SKATERNA; Olha HUDKOVA; Nely LATYSHKO; Olha KHUDIAKOVA; Kateryna TOKARCHUK; Iryna KRYSIUK; Teriana KISHKO; Lucia KNOPFOVÁ a Liudmyla DROBOT. Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer. In Current Issues od Biochemistry and Biotechnology 2024. 2024. ISSN 2410-776X. Dostupné z: https://doi.org/10.15407/biotech17.02.007.

@proceedings{2421890,
   author = {Horak, Iryna and Skaterna, Tetiana and Hudkova, Olha and Latyshko, Nely and Khudiakova, Olha and Tokarchuk, Kateryna and Krysiuk, Iryna and Kishko, Teriana and Knopfová, Lucia and Drobot, Liudmyla},
   booktitle = {Current Issues od Biochemistry and Biotechnology 2024},
   doi = {https://doi.org/10.15407/biotech17.02.007},
   keywords = {Adaptor protein Ruk/CIN85; breast cancer; lung cancer; osteosarcoma; motility; metastasis; cancer stem cells; drug resistance; cancer cell plasticity},
   language = {eng},
   title = {Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer},
   url = {https://biotechnology.kiev.ua/images/BTA/2024/2_2024/Horak_2_2024.pdf},
   year = {2024}
}

TY  - CONF
ID  - 2421890
AU  - Horak, Iryna - Skaterna, Tetiana - Hudkova, Olha - Latyshko, Nely - Khudiakova, Olha - Tokarchuk, Kateryna - Krysiuk, Iryna - Kishko, Teriana - Knopfová, Lucia - Drobot, Liudmyla
PY  - 2024
TI  - Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer
KW  - Adaptor protein Ruk/CIN85
KW  - breast cancer
KW  - lung cancer
KW  - osteosarcoma
KW  - motility
KW  - metastasis
KW  - cancer stem cells
KW  - drug resistance
KW  - cancer cell plasticity
UR  - https://biotechnology.kiev.ua/images/BTA/2024/2_2024/Horak_2_2024.pdf
N2  - Using cellular models of breast, lung, and bone cancer, the effects of Ruk/CIN85 on multiple attributes of cancer cell plasticity were investigated. It was demonstrated that overexpression of Ruk/CIN85 resulted in elevated motility in vitro and metastatic potential in vivo, while Ruk/CIN85-knockdown cells are characterized by a lack of migration and metastasis. In addition, a high expression level of Ruk/CIN85 is necessary for the acquisition of resistance to anticancer drugs. Analysis of possible molecular mechanisms revealed expression of EMT- and CSCs-related markers, ECM remodeling ability, as well as metabolic reprogramming (Warburg effect) in Ruk/CIN85-overexpressing cells. On the contrary, Ruk/CIN85 knockdown resulted in the acquisition of a more differentiated phenotype with increased adhesion and proliferation.
ER  -

HORAK, Iryna; Tetiana SKATERNA; Olha HUDKOVA; Nely LATYSHKO; Olha KHUDIAKOVA; Kateryna TOKARCHUK; Iryna KRYSIUK; Teriana KISHKO; Lucia KNOPFOVÁ a Liudmyla DROBOT. Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer. In \textit{Current Issues od Biochemistry and Biotechnology 2024}. 2024. ISSN~2410-776X. Dostupné z: https://doi.org/10.15407/biotech17.02.007.

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