The interplay of transition metals in ferroptosis and
pyroptosis

J 2024

The interplay of transition metals in ferroptosis and pyroptosis

VÁŇA, František, Zoltán SZABÓ, Michal MASAŘÍK a Monika KRATOCHVÍLOVÁ

Základní údaje

Originální název

The interplay of transition metals in ferroptosis and pyroptosis

Autoři

VÁŇA, František (203 Česká republika, domácí), Zoltán SZABÓ (703 Slovensko, domácí), Michal MASAŘÍK (203 Česká republika, domácí) a Monika KRATOCHVÍLOVÁ (203 Česká republika, domácí)

Vydání

Cell Division, London, BMC, 2024, 1747-1028

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.300 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/s13008-024-00127-9

UT WoS

001282976300001

Klíčová slova anglicky

ferroptosis; pyroptosis; transition metals; interplay

Štítky

14110515, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 8. 2024 11:06, Mgr. Tereza Miškechová

Anotace

V originále

Cell death is one of the most important mechanisms of maintaining homeostasis in our body. Ferroptosis and pyroptosis are forms of necrosis-like cell death. These cell death modalities play key roles in the pathophysiology of cancer, cardiovascular, neurological diseases, and other pathologies. Transition metals are abundant group of elements in all living organisms. This paper presents a summary of ferroptosis and pyroptosis pathways and their connection to significant transition metals, namely zinc (Zn), copper (Cu), molybdenum (Mo), lead (Pb), cobalt (Co), iron (Fe), cadmium (Cd), nickel (Ni), mercury (Hg), uranium (U), platinum (Pt), and one crucial element, selenium (Se). Authors aim to summarize the up-to-date knowledge of this topic. In this review, there are categorized and highlighted the most common patterns in the alterations of ferroptosis and pyroptosis by transition metals. Special attention is given to zinc since collected data support its dual nature of action in both ferroptosis and pyroptosis. All findings are presented together with a brief description of major biochemical pathways involving mentioned metals and are visualized in attached comprehensive figures. This work concludes that the majority of disruptions in the studied metals’ homeostasis impacts cell fate, influencing both death and survival of cells in the complex system of altered pathways. Therefore, this summary opens up the space for further research.

Návaznosti

MUNI/A/1547/2023, interní kód MU

Název: Analýza (dys)funkce: od molekul k živému organismu

Investor: Masarykova univerzita, Analýza (dys)funkce: od molekul k živému organismu

MUNI/A/1587/2023, interní kód MU

Název: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masarykova univerzita, Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Citovat

VÁŇA, František, Zoltán SZABÓ, Michal MASAŘÍK a Monika KRATOCHVÍLOVÁ. The interplay of transition metals in ferroptosis and pyroptosis. Cell Division. London: BMC, 2024, roč. 19, č. 1, s. 1-26. ISSN 1747-1028. Dostupné z: https://dx.doi.org/10.1186/s13008-024-00127-9.

@article{2422317,
   author = {Váňa, František and Szabó, Zoltán and Masařík, Michal and Kratochvílová, Monika},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s13008-024-00127-9},
   keywords = {ferroptosis; pyroptosis; transition metals; interplay},
   language = {eng},
   issn = {1747-1028},
   journal = {Cell Division},
   title = {The interplay of transition metals in ferroptosis and pyroptosis},
   url = {https://celldiv.biomedcentral.com/articles/10.1186/s13008-024-00127-9},
   volume = {19},
   year = {2024}
}

TY  - JOUR
ID  - 2422317
AU  - Váňa, František - Szabó, Zoltán - Masařík, Michal - Kratochvílová, Monika
PY  - 2024
TI  - The interplay of transition metals in ferroptosis and pyroptosis
JF  - Cell Division
VL  - 19
IS  - 1
SP  - 1-26
EP  - 1-26
PB  - BMC
SN  - 17471028
KW  - ferroptosis
KW  - pyroptosis
KW  - transition metals
KW  - interplay
UR  - https://celldiv.biomedcentral.com/articles/10.1186/s13008-024-00127-9
N2  - Cell death is one of the most important mechanisms of maintaining homeostasis in our body. Ferroptosis and pyroptosis are forms of necrosis-like cell death. These cell death modalities play key roles in the pathophysiology of cancer, cardiovascular, neurological diseases, and other pathologies. Transition metals are abundant group of elements in all living organisms. This paper presents a summary of ferroptosis and pyroptosis pathways and their connection to significant transition metals, namely zinc (Zn), copper (Cu), molybdenum (Mo), lead (Pb), cobalt (Co), iron (Fe), cadmium (Cd), nickel (Ni), mercury (Hg), uranium (U), platinum (Pt), and one crucial element, selenium (Se). Authors aim to summarize the up-to-date knowledge of this topic. In this review, there are categorized and highlighted the most common patterns in the alterations of ferroptosis and pyroptosis by transition metals. Special attention is given to zinc since collected data support its dual nature of action in both ferroptosis and pyroptosis. All findings are presented together with a brief description of major biochemical pathways involving mentioned metals and are visualized in attached comprehensive figures. This work concludes that the majority of disruptions in the studied metals’ homeostasis impacts cell fate, influencing both death and survival of cells in the complex system of altered pathways. Therefore, this summary opens up the space for further research.
ER  -

VÁŇA, František, Zoltán SZABÓ, Michal MASAŘÍK a Monika KRATOCHVÍLOVÁ. The interplay of transition metals in ferroptosis and pyroptosis. \textit{Cell Division}. London: BMC, 2024, roč.~19, č.~1, s.~1-26. ISSN~1747-1028. Dostupné z: https://dx.doi.org/10.1186/s13008-024-00127-9.

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