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@article{2423182, author = {Mahon, FrancoisandXavier and Pfirrmann, Markus and Dulucq, Stephanie and Hochhaus, Andreas and Panayiotidis, Panayiotis and Almeida, Antonio and Mayer, Jiří and HjorthandHansen, Henrik and Janssen, Jeroen J W M and Mustjoki, Satu and MartinezandLopez, Joaquin and Vestergaard, Hanne and Ehrencrona, Hans and Polakova, Katerina Machova and OlssonandStroemberg, Ulla and Ossenkoppele, Gert and Berger, Marc G and Etienne, Gabriel and Dengler, Jolanta and Bruemmendorf, Tim H and Burchert, Andreas and Rea, Delphine and Rousselot, Philippe and Nicolini, Franck E and Hofmann, WolfandKarsten and Richter, Johan and Saussele, Susanne}, article_location = {PHILADELPHIA}, article_number = {16}, doi = {http://dx.doi.org/10.1200/JCO.23.01647}, keywords = {Chronic Myeloid Leukemia; EURO-SKI}, language = {eng}, issn = {0732-183X}, journal = {Journal of clinical oncology}, title = {European Stop Tyrosine Kinase Inhibitor Trial (EURO-SKI) in Chronic Myeloid Leukemia: Final Analysis and Novel Prognostic Factors for Treatment-Free Remission}, url = {https://ascopubs.org/doi/10.1200/JCO.23.01647}, volume = {42}, year = {2024} }
TY - JOUR ID - 2423182 AU - Mahon, Francois-Xavier - Pfirrmann, Markus - Dulucq, Stephanie - Hochhaus, Andreas - Panayiotidis, Panayiotis - Almeida, Antonio - Mayer, Jiří - Hjorth-Hansen, Henrik - Janssen, Jeroen J W M - Mustjoki, Satu - Martinez-Lopez, Joaquin - Vestergaard, Hanne - Ehrencrona, Hans - Polakova, Katerina Machova - Olsson-Stroemberg, Ulla - Ossenkoppele, Gert - Berger, Marc G - Etienne, Gabriel - Dengler, Jolanta - Bruemmendorf, Tim H - Burchert, Andreas - Rea, Delphine - Rousselot, Philippe - Nicolini, Franck E - Hofmann, Wolf-Karsten - Richter, Johan - Saussele, Susanne PY - 2024 TI - European Stop Tyrosine Kinase Inhibitor Trial (EURO-SKI) in Chronic Myeloid Leukemia: Final Analysis and Novel Prognostic Factors for Treatment-Free Remission JF - Journal of clinical oncology VL - 42 IS - 16 SP - 1-11 EP - 1-11 PB - LIPPINCOTT WILLIAMS & WILKINS SN - 0732183X KW - Chronic Myeloid Leukemia KW - EURO-SKI UR - https://ascopubs.org/doi/10.1200/JCO.23.01647 N2 - Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.The European Stop Kinase Inhibitors (EURO-SKI) study is the largest clinical trial for investigating the cessation of tyrosine kinase inhibitors (TKIs) in patients with chronic myeloid leukemia in stable deep molecular remission (DMR). Among 728 patients, 434 patients (61%; 95% CI, 57 to 64) remained in major molecular response (MMR) at 6 months and 309 patients of 678 (46%; 95% CI, 42 to 49) at 36 months. Duration of TKI treatment and DMR before TKI stop were confirmed as significant factors for the prediction of MMR loss at 6 months. In addition, the type of BCR::ABL1 transcript was identified as a prognostic factor. For late MMR losses after 6 months, TKI treatment duration, percentage of blasts in peripheral blood, and platelet count at diagnosis were significant factors in multivariate analysis. For the entire study period of 36 months, multiple logistic regression models confirmed duration of treatment, blasts, and transcript type as independent factors for MMR maintenance. In addition to the duration of treatment, transcript type as well as blasts in peripheral blood at diagnosis should be considered as important factors to predict treatment-free remission. ER -
MAHON, Francois-Xavier, Markus PFIRRMANN, Stephanie DULUCQ, Andreas HOCHHAUS, Panayiotis PANAYIOTIDIS, Antonio ALMEIDA, Jiří MAYER, Henrik HJORTH-HANSEN, Jeroen J W M JANSSEN, Satu MUSTJOKI, Joaquin MARTINEZ-LOPEZ, Hanne VESTERGAARD, Hans EHRENCRONA, Katerina Machova POLAKOVA, Ulla OLSSON-STROEMBERG, Gert OSSENKOPPELE, Marc G BERGER, Gabriel ETIENNE, Jolanta DENGLER, Tim H BRUEMMENDORF, Andreas BURCHERT, Delphine REA, Philippe ROUSSELOT, Franck E NICOLINI, Wolf-Karsten HOFMANN, Johan RICHTER a Susanne SAUSSELE. European Stop Tyrosine Kinase Inhibitor Trial (EURO-SKI) in Chronic Myeloid Leukemia: Final Analysis and Novel Prognostic Factors for Treatment-Free Remission. \textit{Journal of clinical oncology}. PHILADELPHIA: LIPPINCOTT WILLIAMS \&{} WILKINS, 2024, roč.~42, č.~16, s.~1-11. ISSN~0732-183X. Dostupné z: https://dx.doi.org/10.1200/JCO.23.01647.
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