Clear surgical margins as a prognostic indicator for disease
recurrence, with no impact on survival rates in patients with
myxofibrosarcoma

J 2024

Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma

TOMÁŠ, Tomáš; Vasileios APOSTOLOPOULOS; Lukáš PAZOUREK; Marian KUBÍČEK; Iva ZAMBO et al.

Základní údaje

Originální název

Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma

Autoři

TOMÁŠ, Tomáš; Vasileios APOSTOLOPOULOS; Lukáš PAZOUREK; Marian KUBÍČEK; Iva ZAMBO; Dagmar ADÁMKOVÁ; Pavel ŠLAMPA a Michal MAHDAL

Vydání

Scientific Reports, London, NATURE RESEARCH, 2024, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00136803

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

myxofibrosarcoma

Štítky

14110112, 14110123, 14110811, 14110812, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 8. 2024 12:19, Mgr. Tereza Miškechová

Anotace

V originále

Myxofibrosarcoma presents an infiltrating growth pattern that results in a high tendency for local recurrence. Clear margin resection is challenging because of microscopic infiltration. The purpose of the present study was to analyze the overall and disease-free survival rates of patients with myxofibrosarcoma and the prognostic factors that determine both survival and disease recurrence. Among the 111 patients included in our study, the 5-year overall survival rate was 65.5%. An age of more than 65 years (hazard ratio [HR] 1.9 [95% confidence interval (CI) 1.4-5.6]; p < 0.001), a tumor size of more than 5 cm (HR 2.8 [95% CI 0.9-8.1]; p = 0.049) and the G3 tumor grade (HR 14.1 [95% CI 2.1-105.0]; p < 0.001) negatively affected overall survival. The 5-year recurrence-free survival rate was 49.4%. R1/R2-type resection (HR 2.4 [95% CI 1.0-5.6]; p = 0.048) had a detrimental effect on tumor recurrence. Clear margins had a positive impact on recurrence-free survival, but did not significantly affect overall patient survival, suggesting that other factors may play a more significant role in determining patient outcomes. A surgical margin of 2 mm was not sufficient to significantly influence the incidence of recurrence. Consequently, a wider surgical margin may be necessary to reduce the risk of myxofibrosarcoma recurrence.

Citovat

TOMÁŠ, Tomáš; Vasileios APOSTOLOPOULOS; Lukáš PAZOUREK; Marian KUBÍČEK; Iva ZAMBO; Dagmar ADÁMKOVÁ; Pavel ŠLAMPA a Michal MAHDAL. Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma. Scientific Reports. London: NATURE RESEARCH, 2024, roč. 14, č. 1, s. 1-10. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-024-63035-6.

@article{2423184,
   author = {Tomáš, Tomáš and Apostolopoulos, Vasileios and Pazourek, Lukáš and Kubíček, Marian and Zambo, Iva and Adámková, Dagmar and Šlampa, Pavel and Mahdal, Michal},
   article_location = {London},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-024-63035-6},
   keywords = {myxofibrosarcoma},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma},
   url = {https://www.nature.com/articles/s41598-024-63035-6},
   volume = {14},
   year = {2024}
}

TY  - JOUR
ID  - 2423184
AU  - Tomáš, Tomáš - Apostolopoulos, Vasileios - Pazourek, Lukáš - Kubíček, Marian - Zambo, Iva - Adámková, Dagmar - Šlampa, Pavel - Mahdal, Michal
PY  - 2024
TI  - Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma
JF  - Scientific Reports
VL  - 14
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - NATURE RESEARCH
SN  - 20452322
KW  - myxofibrosarcoma
UR  - https://www.nature.com/articles/s41598-024-63035-6
N2  - Myxofibrosarcoma presents an infiltrating growth pattern that results in a high tendency for local recurrence. Clear margin resection is challenging because of microscopic infiltration. The purpose of the present study was to analyze the overall and disease-free survival rates of patients with myxofibrosarcoma and the prognostic factors that determine both survival and disease recurrence. Among the 111 patients included in our study, the 5-year overall survival rate was 65.5%. An age of more than 65 years (hazard ratio [HR] 1.9 [95% confidence interval (CI) 1.4-5.6]; p < 0.001), a tumor size of more than 5 cm (HR 2.8 [95% CI 0.9-8.1]; p = 0.049) and the G3 tumor grade (HR 14.1 [95% CI 2.1-105.0]; p < 0.001) negatively affected overall survival. The 5-year recurrence-free survival rate was 49.4%. R1/R2-type resection (HR 2.4 [95% CI 1.0-5.6]; p = 0.048) had a detrimental effect on tumor recurrence. Clear margins had a positive impact on recurrence-free survival, but did not significantly affect overall patient survival, suggesting that other factors may play a more significant role in determining patient outcomes. A surgical margin of 2 mm was not sufficient to significantly influence the incidence of recurrence. Consequently, a wider surgical margin may be necessary to reduce the risk of myxofibrosarcoma recurrence.
ER  -

TOMÁŠ, Tomáš; Vasileios APOSTOLOPOULOS; Lukáš PAZOUREK; Marian KUBÍČEK; Iva ZAMBO; Dagmar ADÁMKOVÁ; Pavel ŠLAMPA a Michal MAHDAL. Clear surgical margins as a prognostic indicator for disease recurrence, with no impact on survival rates in patients with myxofibrosarcoma. \textit{Scientific Reports}. London: NATURE RESEARCH, 2024, roč.~14, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-024-63035-6.

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