Migraine - a borderland disease to epilepsy: near it but not of
it

J 2024

Migraine - a borderland disease to epilepsy: near it but not of it

PAUNGARTTNER, Jakob; Martina QUARTANA; Lucrezia PATTI; Barbora SKLENÁROVÁ; Fatemeh FARHAM et. al.

Základní údaje

Originální název

Migraine - a borderland disease to epilepsy: near it but not of it

Autoři

Vydání

JOURNAL OF HEADACHE AND PAIN, LONDON, BMC, 2024, 1129-2369

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.900

Kód RIV

RIV/00216224:14110/24:00136825

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1186/s10194-024-01719-0

UT WoS

001148741800001

EID Scopus

2-s2.0-85182987193

Klíčová slova anglicky

Migraine; Epilepsy; Neurotransmitters; Genetics; Hemiplegic migraine; Migralepsy; Anti-seizure medication

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 3. 2025 09:40, Mgr. Tereza Miškechová

Anotace

V originále

BackgroundMigraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and socioeconomic burden. The link between these disorders has been of interest for decades and innovations concerning diagnosing and treatment enable new insights into their relationship.FindingsAlthough appearing to be distinct at first glance, both diseases exhibit a noteworthy comorbidity, shared pathophysiological pathways, and significant overlaps in characteristics like clinical manifestation or prophylactic treatment. This review aims to explore the intricate relationship between these two conditions, shedding light on shared pathophysiological foundations, genetic interdependencies, common and distinct clinical features, clinically overlapping syndromes, and therapeutic similarities. There are several shared pathophysiological mechanisms, like CSD, the likely underlying cause of migraine aura, or neurotransmitters, mainly Glutamate and GABA, which represent important roles in triggering migraine attacks and seizures. The genetic interrelations between the two disorders can be observed by taking a closer look at the group of familial hemiplegic migraines, which are caused by mutations in genes like CACNA1A, ATP1A2, or SCN1A. The intricate relationship is further underlined by the high number of shared clinical features, which can be observed over the entire course of migraine attacks and epileptic seizures. While the variety of the clinical manifestation of an epileptic seizure is naturally higher than that of a migraine attack, a distinction can indeed be difficult in some cases, e.g. in occipital lobe epilepsy. Moreover, triggering factors like sleep deprivation or alcohol consumption play an important role in both diseases. In the period after the seizure or migraine attack, symptoms like speech difficulties, tiredness, and yawning occur. While the actual attack of the disease usually lasts for a limited time, research indicates that individuals suffering from migraine and/or epilepsy are highly affected in their daily life, especially regarding cognitive and social aspects, a burden that is even worsened using antiseizure medication. This medication allows us to reveal further connections, as certain antiepileptics are proven to have beneficial effects on the frequency and severity of migraine and have been used as a preventive drug for both diseases over many years.ConclusionMigraine and epilepsy show a high number of similarities in their mechanisms and clinical presentation. A deeper understanding of the intricate relationship will positively advance patient-oriented research and clinical work.

Citovat

PAUNGARTTNER, Jakob; Martina QUARTANA; Lucrezia PATTI; Barbora SKLENÁROVÁ; Fatemeh FARHAM; Ines Hernando JIMENEZ; M Gokcen SOYLU; Irina Maria VLAD; Semih TASDELEN; Teresa MATEU; Oreste MARSICO; Federica REINA; Viktoria TISCHLER a Christian LAMPL. Migraine - a borderland disease to epilepsy: near it but not of it. JOURNAL OF HEADACHE AND PAIN. LONDON: BMC, 2024, roč. 25, č. 1, s. 1-23. ISSN 1129-2369. Dostupné z: https://doi.org/10.1186/s10194-024-01719-0.

@article{2423279,
   author = {Paungarttner, Jakob and Quartana, Martina and Patti, Lucrezia and Sklenárová, Barbora and Farham, Fatemeh and Jimenez, Ines Hernando and Soylu, M Gokcen and Vlad, Irina Maria and Tasdelen, Semih and Mateu, Teresa and Marsico, Oreste and Reina, Federica and Tischler, Viktoria and Lampl, Christian},
   article_location = {LONDON},
   article_number = {1},
   doi = {https://doi.org/10.1186/s10194-024-01719-0},
   keywords = {Migraine; Epilepsy; Neurotransmitters; Genetics; Hemiplegic migraine; Migralepsy; Anti-seizure medication},
   language = {eng},
   issn = {1129-2369},
   journal = {JOURNAL OF HEADACHE AND PAIN},
   title = {Migraine - a borderland disease to epilepsy: near it but not of it},
   url = {https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-024-01719-0},
   volume = {25},
   year = {2024}
}

TY  - JOUR
ID  - 2423279
AU  - Paungarttner, Jakob - Quartana, Martina - Patti, Lucrezia - Sklenárová, Barbora - Farham, Fatemeh - Jimenez, Ines Hernando - Soylu, M Gokcen - Vlad, Irina Maria - Tasdelen, Semih - Mateu, Teresa - Marsico, Oreste - Reina, Federica - Tischler, Viktoria - Lampl, Christian
PY  - 2024
TI  - Migraine - a borderland disease to epilepsy: near it but not of it
JF  - JOURNAL OF HEADACHE AND PAIN
VL  - 25
IS  - 1
SP  - 1-23
EP  - 1-23
PB  - BMC
SN  - 11292369
KW  - Migraine
KW  - Epilepsy
KW  - Neurotransmitters
KW  - Genetics
KW  - Hemiplegic migraine
KW  - Migralepsy
KW  - Anti-seizure medication
UR  - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-024-01719-0
N2  - BackgroundMigraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and socioeconomic burden. The link between these disorders has been of interest for decades and innovations concerning diagnosing and treatment enable new insights into their relationship.FindingsAlthough appearing to be distinct at first glance, both diseases exhibit a noteworthy comorbidity, shared pathophysiological pathways, and significant overlaps in characteristics like clinical manifestation or prophylactic treatment. This review aims to explore the intricate relationship between these two conditions, shedding light on shared pathophysiological foundations, genetic interdependencies, common and distinct clinical features, clinically overlapping syndromes, and therapeutic similarities. There are several shared pathophysiological mechanisms, like CSD, the likely underlying cause of migraine aura, or neurotransmitters, mainly Glutamate and GABA, which represent important roles in triggering migraine attacks and seizures. The genetic interrelations between the two disorders can be observed by taking a closer look at the group of familial hemiplegic migraines, which are caused by mutations in genes like CACNA1A, ATP1A2, or SCN1A. The intricate relationship is further underlined by the high number of shared clinical features, which can be observed over the entire course of migraine attacks and epileptic seizures. While the variety of the clinical manifestation of an epileptic seizure is naturally higher than that of a migraine attack, a distinction can indeed be difficult in some cases, e.g. in occipital lobe epilepsy. Moreover, triggering factors like sleep deprivation or alcohol consumption play an important role in both diseases. In the period after the seizure or migraine attack, symptoms like speech difficulties, tiredness, and yawning occur. While the actual attack of the disease usually lasts for a limited time, research indicates that individuals suffering from migraine and/or epilepsy are highly affected in their daily life, especially regarding cognitive and social aspects, a burden that is even worsened using antiseizure medication. This medication allows us to reveal further connections, as certain antiepileptics are proven to have beneficial effects on the frequency and severity of migraine and have been used as a preventive drug for both diseases over many years.ConclusionMigraine and epilepsy show a high number of similarities in their mechanisms and clinical presentation. A deeper understanding of the intricate relationship will positively advance patient-oriented research and clinical work.
ER  -

PAUNGARTTNER, Jakob; Martina QUARTANA; Lucrezia PATTI; Barbora SKLENÁROVÁ; Fatemeh FARHAM; Ines Hernando JIMENEZ; M Gokcen SOYLU; Irina Maria VLAD; Semih TASDELEN; Teresa MATEU; Oreste MARSICO; Federica REINA; Viktoria TISCHLER a Christian LAMPL. Migraine - a borderland disease to epilepsy: near it but not of it. \textit{JOURNAL OF HEADACHE AND PAIN}. LONDON: BMC, 2024, roč.~25, č.~1, s.~1-23. ISSN~1129-2369. Dostupné z: https://doi.org/10.1186/s10194-024-01719-0.

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