Hyaluronic Acid Nanoparticles with Parameters Required for In
Vivo Applications: From Synthesis to Parametrization

J 2024

Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization

MATĚJKOVÁ, Nikola; Lucie KORECKÁ; Petr ŠÁLEK; Olga KOČKOVÁ; Ewa PAVLOVA et al.

Základní údaje

Originální název

Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization

Autoři

Vydání

Biomacromolecules, Washington, DC, American Chemical Society, 2024, 1525-7797

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.400

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00136928

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Hyaluronic acid; Nanoparticle; Synthesis; Characterization

Štítky

14313050, CF NANO, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 3. 2025 15:01, Mgr. Eva Dubská

Anotace

V originále

Hyaluronic acid is an excellent biocompatible material for in vivo applications. Its ability to bind CD44, a cell receptor involved in numerous biological processes, predetermines HA-based nanomaterials as unique carrier for therapeutic and theranostic applications. Although numerous methods for the synthesis of hyaluronic acid nanoparticles (HANPs) are available today, their low reproducibility and wide size distribution hinder the precise assessment of the effect on the organism. A robust and reproducible approach for producing HANPs that meet strict criteria for in vivo applications (e.g., to lung parenchyma) remains challenging. We designed and evaluated four protocols for the preparation of HANPs with those required parameters. The HA molecule was cross-linked by novel combinations of carbodiimide, and four different amine-containing compounds resulted in monodisperse HANPs with a low polydispersity index. By a complex postsynthetic characterization, we confirmed that the prepared HANPs meet the criteria for inhaled therapeutic delivery and other in vivo applications.

Návaznosti

EF18_046/0015974, projekt VaV

Název: Modernizace České infrastruktury pro integrativní strukturní biologii

90242, velká výzkumná infrastruktura

Název: CIISB III

Citovat

MATĚJKOVÁ, Nikola; Lucie KORECKÁ; Petr ŠÁLEK; Olga KOČKOVÁ; Ewa PAVLOVA; Jitka KAŠPAROVÁ; Radka OBOŘILOVÁ; Zdeněk FARKA; Karel FROLICH; Martin ADAM; Anna CARRILLO; Zuzana ŠINKOROVÁ a Zuzana BÍLKOVÁ. Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization. Biomacromolecules. Washington, DC: American Chemical Society, 2024, roč. 25, č. 8, s. 4934-4945. ISSN 1525-7797. Dostupné z: https://doi.org/10.1021/acs.biomac.4c00370.

@article{2425617,
   author = {Matějková, Nikola and Korecká, Lucie and Šálek, Petr and Kočková, Olga and Pavlova, Ewa and Kašparová, Jitka and Obořilová, Radka and Farka, Zdeněk and Frolich, Karel and Adam, Martin and Carrillo, Anna and Šinkorová, Zuzana and Bílková, Zuzana},
   article_location = {Washington, DC},
   article_number = {8},
   doi = {https://doi.org/10.1021/acs.biomac.4c00370},
   keywords = {Hyaluronic acid; Nanoparticle; Synthesis; Characterization},
   language = {eng},
   issn = {1525-7797},
   journal = {Biomacromolecules},
   title = {Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization},
   url = {https://pubs.acs.org/doi/10.1021/acs.biomac.4c00370},
   volume = {25},
   year = {2024}
}

TY  - JOUR
ID  - 2425617
AU  - Matějková, Nikola - Korecká, Lucie - Šálek, Petr - Kočková, Olga - Pavlova, Ewa - Kašparová, Jitka - Obořilová, Radka - Farka, Zdeněk - Frolich, Karel - Adam, Martin - Carrillo, Anna - Šinkorová, Zuzana - Bílková, Zuzana
PY  - 2024
TI  - Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization
JF  - Biomacromolecules
VL  - 25
IS  - 8
SP  - 4934-4945
EP  - 4934-4945
PB  - American Chemical Society
SN  - 15257797
KW  - Hyaluronic acid
KW  - Nanoparticle
KW  - Synthesis
KW  - Characterization
UR  - https://pubs.acs.org/doi/10.1021/acs.biomac.4c00370
N2  - Hyaluronic acid is an excellent biocompatible material for in vivo applications. Its ability to bind CD44, a cell receptor involved in numerous biological processes, predetermines HA-based nanomaterials as unique carrier for therapeutic and theranostic applications. Although numerous methods for the synthesis of hyaluronic acid nanoparticles (HANPs) are available today, their low reproducibility and wide size distribution hinder the precise assessment of the effect on the organism. A robust and reproducible approach for producing HANPs that meet strict criteria for in vivo applications (e.g., to lung parenchyma) remains challenging. We designed and evaluated four protocols for the preparation of HANPs with those required parameters. The HA molecule was cross-linked by novel combinations of carbodiimide, and four different amine-containing compounds resulted in monodisperse HANPs with a low polydispersity index. By a complex postsynthetic characterization, we confirmed that the prepared HANPs meet the criteria for inhaled therapeutic delivery and other in vivo applications.
ER  -

MATĚJKOVÁ, Nikola; Lucie KORECKÁ; Petr ŠÁLEK; Olga KOČKOVÁ; Ewa PAVLOVA; Jitka KAŠPAROVÁ; Radka OBOŘILOVÁ; Zdeněk FARKA; Karel FROLICH; Martin ADAM; Anna CARRILLO; Zuzana ŠINKOROVÁ a Zuzana BÍLKOVÁ. Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization. \textit{Biomacromolecules}. Washington, DC: American Chemical Society, 2024, roč.~25, č.~8, s.~4934-4945. ISSN~1525-7797. Dostupné z: https://doi.org/10.1021/acs.biomac.4c00370.

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