Post-vaccination, post-infection and hybrid immunity against
severe cases of COVID-19 and long COVID after infection with
SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to
August 2023

J 2024

Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023

ŠMÍD, Martin; Tamara BARUSOVÁ; Jiří JARKOVSKÝ; Ondřej MÁJEK; Tomáš PAVLÍK et. al.

Základní údaje

Originální název

Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023

Autoři

ŠMÍD, Martin; Tamara BARUSOVÁ; Jiří JARKOVSKÝ ; Ondřej MÁJEK ; Tomáš PAVLÍK; Lenka PŘIBYLOVÁ; Josefína WEINEROVÁ; Milan ZAJÍČEK a Jan TRNKA

Vydání

Eurosurveillance, European Centre for Disease Prevention and Control, 2024, 1025-496X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Švédsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.800

Kód RIV

RIV/00216224:14110/24:00137012

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.2807/1560-7917.ES.2024.29.35.2300690

UT WoS

001308042700002

EID Scopus

2-s2.0-85203081831

Klíčová slova anglicky

COVID-19; SARS-CoV-2 Omicron subvariants; post-vaccination; post-infection; hybrid immunity

Štítky

14119612, 14311010, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 10. 2024 10:04, Mgr. Tereza Miškechová

Anotace

V originále

Background COVID-19 remains a major infectious disease with substantial implications for individual and public health including the risk of a post-infection syndrome, long COVID. The continuous changes in dominant variants of SARS-CoV-2 necessitate a careful study of the effect of preventative strategies. Aim We aimed to estimate the effectiveness of post-vaccination, post-infection and hybrid immunity against severe cases requiring oxygen support caused by infections with SARS-CoV-2 variants BA1/2 and BA4/5+, and against long COVID in the infected population and their changes over time. Methods We used a Cox regression analysis with time-varying covariates and calendar time and logistic regression applied to national-level data from Czechia from December 2021 until August 2023. Results Recently boosted vaccination, post-infection and hybrid immunity provide significant protection against a severe course of COVID-19, while unboosted vaccination more than 10 months ago has a negligible protective effect. The post-vaccination immunity against the BA1/2 or BA4/5+ variants, especially based on the original vaccine types, appears to wane rapidly compared with post-infection and hybrid immunity. Once infected, however, previous immunity plays only a small protective role against long COVID. Conclusion Vaccination remains an effective preventative measure against a severe course of COVID-19 but its effectiveness wanes over time thus highlighting the importance of booster doses. Once infected, vaccines may have a small protective effect against the development of long COVID.

Návaznosti

MUNI/A/1132/2022, interní kód MU

Název: Matematické a statistické modelování 7

Investor: Masarykova univerzita, Matematické a statistické modelování 7

101063853, interní kód MU

Název: Models with cross-interactions between partial dynamical processes aiming to understand significant or abrupt dynamic changes. (Akronym: CrossInteractions)

Investor: Evropská unie, Models with cross-interactions between partial dynamical processes aiming to understand significant or abrupt dynamic changes., Marie Skłodowska-Curie Postdoctoral Fellowships (MSCA PF)

Citovat

ŠMÍD, Martin; Tamara BARUSOVÁ; Jiří JARKOVSKÝ; Ondřej MÁJEK; Tomáš PAVLÍK; Lenka PŘIBYLOVÁ; Josefína WEINEROVÁ; Milan ZAJÍČEK a Jan TRNKA. Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023. Eurosurveillance. European Centre for Disease Prevention and Control, 2024, roč. 29, č. 35, s. 1-10. ISSN 1025-496X. Dostupné z: https://doi.org/10.2807/1560-7917.ES.2024.29.35.2300690.

@article{2428440,
   author = {Šmíd, Martin and Barusová, Tamara and Jarkovský, Jiří and Májek, Ondřej and Pavlík, Tomáš and Přibylová, Lenka and Weinerová, Josefína and Zajíček, Milan and Trnka, Jan},
   article_number = {35},
   doi = {https://doi.org/10.2807/1560-7917.ES.2024.29.35.2300690},
   keywords = {COVID-19; SARS-CoV-2 Omicron subvariants; post-vaccination; post-infection; hybrid immunity},
   language = {eng},
   issn = {1025-496X},
   journal = {Eurosurveillance},
   title = {Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023},
   url = {https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.35.2300690},
   volume = {29},
   year = {2024}
}

TY  - JOUR
ID  - 2428440
AU  - Šmíd, Martin - Barusová, Tamara - Jarkovský, Jiří - Májek, Ondřej - Pavlík, Tomáš - Přibylová, Lenka - Weinerová, Josefína - Zajíček, Milan - Trnka, Jan
PY  - 2024
TI  - Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023
JF  - Eurosurveillance
VL  - 29
IS  - 35
SP  - 1-10
EP  - 1-10
PB  - European Centre for Disease Prevention and Control
SN  - 1025496X
KW  - COVID-19
KW  - SARS-CoV-2 Omicron subvariants
KW  - post-vaccination
KW  - post-infection
KW  - hybrid immunity
UR  - https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.35.2300690
N2  - Background COVID-19 remains a major infectious disease with substantial implications for individual and public health including the risk of a post-infection syndrome, long COVID. The continuous changes in dominant variants of SARS-CoV-2 necessitate a careful study of the effect of preventative strategies. Aim We aimed to estimate the effectiveness of post-vaccination, post-infection and hybrid immunity against severe cases requiring oxygen support caused by infections with SARS-CoV-2 variants BA1/2 and BA4/5+, and against long COVID in the infected population and their changes over time. Methods We used a Cox regression analysis with time-varying covariates and calendar time and logistic regression applied to national-level data from Czechia from December 2021 until August 2023. Results Recently boosted vaccination, post-infection and hybrid immunity provide significant protection against a severe course of COVID-19, while unboosted vaccination more than 10 months ago has a negligible protective effect. The post-vaccination immunity against the BA1/2 or BA4/5+ variants, especially based on the original vaccine types, appears to wane rapidly compared with post-infection and hybrid immunity. Once infected, however, previous immunity plays only a small protective role against long COVID. Conclusion Vaccination remains an effective preventative measure against a severe course of COVID-19 but its effectiveness wanes over time thus highlighting the importance of booster doses. Once infected, vaccines may have a small protective effect against the development of long COVID.
ER  -

ŠMÍD, Martin; Tamara BARUSOVÁ; Jiří JARKOVSKÝ; Ondřej MÁJEK; Tomáš PAVLÍK; Lenka PŘIBYLOVÁ; Josefína WEINEROVÁ; Milan ZAJÍČEK a Jan TRNKA. Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023. \textit{Eurosurveillance}. European Centre for Disease Prevention and Control, 2024, roč.~29, č.~35, s.~1-10. ISSN~1025-496X. Dostupné z: https://doi.org/10.2807/1560-7917.ES.2024.29.35.2300690.

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