Post-vaccination, post-infection and hybrid immunity against
severe cases of COVID-19 and long COVID after infection with
SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to
August 2023

J 2024

Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023

ŠMÍD, Martin, Tamara BARUSOVÁ, Jiří JARKOVSKÝ, Ondřej MÁJEK, Tomáš PAVLÍK et. al.

Základní údaje

Originální název

Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023

Autoři

ŠMÍD, Martin, Tamara BARUSOVÁ, Jiří JARKOVSKÝ (203 Česká republika, domácí), Ondřej MÁJEK (203 Česká republika, domácí), Tomáš PAVLÍK (203 Česká republika, domácí), Lenka PŘIBYLOVÁ (203 Česká republika, domácí), Josefína WEINEROVÁ, Milan ZAJÍČEK a Jan TRNKA (garant)

Vydání

Eurosurveillance, European Centre for Disease Prevention and Control, 2024, 1025-496X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Švédsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 19.000 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2807/1560-7917.ES.2024.29.35.2300690

UT WoS

001308042700002

Klíčová slova anglicky

COVID-19; SARS-CoV-2 Omicron subvariants; post-vaccination; post-infection; hybrid immunity

Štítky

14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 10. 2024 10:04, Mgr. Tereza Miškechová

Anotace

V originále

Background COVID-19 remains a major infectious disease with substantial implications for individual and public health including the risk of a post-infection syndrome, long COVID. The continuous changes in dominant variants of SARS-CoV-2 necessitate a careful study of the effect of preventative strategies. Aim We aimed to estimate the effectiveness of post-vaccination, post-infection and hybrid immunity against severe cases requiring oxygen support caused by infections with SARS-CoV-2 variants BA1/2 and BA4/5+, and against long COVID in the infected population and their changes over time. Methods We used a Cox regression analysis with time-varying covariates and calendar time and logistic regression applied to national-level data from Czechia from December 2021 until August 2023. Results Recently boosted vaccination, post-infection and hybrid immunity provide significant protection against a severe course of COVID-19, while unboosted vaccination more than 10 months ago has a negligible protective effect. The post-vaccination immunity against the BA1/2 or BA4/5+ variants, especially based on the original vaccine types, appears to wane rapidly compared with post-infection and hybrid immunity. Once infected, however, previous immunity plays only a small protective role against long COVID. Conclusion Vaccination remains an effective preventative measure against a severe course of COVID-19 but its effectiveness wanes over time thus highlighting the importance of booster doses. Once infected, vaccines may have a small protective effect against the development of long COVID.

Návaznosti

MUNI/A/1132/2022, interní kód MU

Název: Matematické a statistické modelování 7

Investor: Masarykova univerzita, Matematické a statistické modelování 7

101063853, interní kód MU

Název: Models with cross-interactions between partial dynamical processes aiming to understand significant or abrupt dynamic changes. (Akronym: CrossInteractions)

Investor: Evropská unie, Models with cross-interactions between partial dynamical processes aiming to understand significant or abrupt dynamic changes., Marie Skłodowska-Curie Postdoctoral Fellowships (MSCA PF)

Citovat

ŠMÍD, Martin, Tamara BARUSOVÁ, Jiří JARKOVSKÝ, Ondřej MÁJEK, Tomáš PAVLÍK, Lenka PŘIBYLOVÁ, Josefína WEINEROVÁ, Milan ZAJÍČEK a Jan TRNKA. Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023. Eurosurveillance. European Centre for Disease Prevention and Control, 2024, roč. 29, č. 35, s. 1-10. ISSN 1025-496X. Dostupné z: https://dx.doi.org/10.2807/1560-7917.ES.2024.29.35.2300690.

@article{2428440,
   author = {Šmíd, Martin and Barusová, Tamara and Jarkovský, Jiří and Májek, Ondřej and Pavlík, Tomáš and Přibylová, Lenka and Weinerová, Josefína and Zajíček, Milan and Trnka, Jan},
   article_number = {35},
   doi = {http://dx.doi.org/10.2807/1560-7917.ES.2024.29.35.2300690},
   keywords = {COVID-19; SARS-CoV-2 Omicron subvariants; post-vaccination; post-infection; hybrid immunity},
   language = {eng},
   issn = {1025-496X},
   journal = {Eurosurveillance},
   title = {Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023},
   url = {https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.35.2300690},
   volume = {29},
   year = {2024}
}

TY  - JOUR
ID  - 2428440
AU  - Šmíd, Martin - Barusová, Tamara - Jarkovský, Jiří - Májek, Ondřej - Pavlík, Tomáš - Přibylová, Lenka - Weinerová, Josefína - Zajíček, Milan - Trnka, Jan
PY  - 2024
TI  - Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023
JF  - Eurosurveillance
VL  - 29
IS  - 35
SP  - 1-10
EP  - 1-10
PB  - European Centre for Disease Prevention and Control
SN  - 1025496X
KW  - COVID-19
KW  - SARS-CoV-2 Omicron subvariants
KW  - post-vaccination
KW  - post-infection
KW  - hybrid immunity
UR  - https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.35.2300690
N2  - Background COVID-19 remains a major infectious disease with substantial implications for individual and public health including the risk of a post-infection syndrome, long COVID. The continuous changes in dominant variants of SARS-CoV-2 necessitate a careful study of the effect of preventative strategies. Aim We aimed to estimate the effectiveness of post-vaccination, post-infection and hybrid immunity against severe cases requiring oxygen support caused by infections with SARS-CoV-2 variants BA1/2 and BA4/5+, and against long COVID in the infected population and their changes over time. Methods We used a Cox regression analysis with time-varying covariates and calendar time and logistic regression applied to national-level data from Czechia from December 2021 until August 2023. Results Recently boosted vaccination, post-infection and hybrid immunity provide significant protection against a severe course of COVID-19, while unboosted vaccination more than 10 months ago has a negligible protective effect. The post-vaccination immunity against the BA1/2 or BA4/5+ variants, especially based on the original vaccine types, appears to wane rapidly compared with post-infection and hybrid immunity. Once infected, however, previous immunity plays only a small protective role against long COVID. Conclusion Vaccination remains an effective preventative measure against a severe course of COVID-19 but its effectiveness wanes over time thus highlighting the importance of booster doses. Once infected, vaccines may have a small protective effect against the development of long COVID.
ER  -

ŠMÍD, Martin, Tamara BARUSOVÁ, Jiří JARKOVSKÝ, Ondřej MÁJEK, Tomáš PAVLÍK, Lenka PŘIBYLOVÁ, Josefína WEINEROVÁ, Milan ZAJÍČEK a Jan TRNKA. Post-vaccination, post-infection and hybrid immunity against severe cases of COVID-19 and long COVID after infection with SARS-CoV-2 Omicron subvariants, Czechia, December 2021 to August 2023. \textit{Eurosurveillance}. European Centre for Disease Prevention and Control, 2024, roč.~29, č.~35, s.~1-10. ISSN~1025-496X. Dostupné z: https://dx.doi.org/10.2807/1560-7917.ES.2024.29.35.2300690.

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