Quantitative and qualitative differences in the activation of a
fibroblast growth factor receptor by different FGF ligands

J 2024

Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

KRZYSCIK, Mateusz A, Kelly KARL, Pooja DUDEJA, Pavel KREJČÍ, Kalina HRISTOVA et. al.

Základní údaje

Originální název

Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands

Autoři

KRZYSCIK, Mateusz A, Kelly KARL, Pooja DUDEJA (356 Indie, domácí), Pavel KREJČÍ (203 Česká republika, domácí) a Kalina HRISTOVA

Vydání

CYTOKINE & GROWTH FACTOR REVIEWS, London, ELSEVIER SCI LTD, 2024, 1359-6101

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 13.000 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.cytogfr.2024.07.002

UT WoS

001297450100001

Klíčová slova anglicky

FGF; FGFR; Signaling; Bias

Štítky

14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 9. 2024 08:36, Mgr. Tereza Miškechová

Anotace

V originále

The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tissue, different FGFs can trigger dramatically different biological responses via this receptor. Here we show both quantitative and qualitative differences in the signaling of one of the FGF receptors, FGFR1c, in response to different FGFs. We provide an overview of the recent discovery that FGFs engage in biased signaling via FGFR1c. We discuss the concept of ligand bias, which represents qualitative differences in signaling as it is a measure of differential ligand preferences for different downstream responses. We show how FGF ligand bias manifests in functional data in cultured chondrocyte cells. We argue that FGF-ligand bias contributes substantially to FGF-driven developmental processes, along with known differences in FGF expression levels, FGF-FGFR binding coefficients and differences in FGF stability in vivo.

Návaznosti

GF21-26400K, projekt VaV

Název: Vztah struktury a funkce v signálováni fibroblastových růstových faktorů

Investor: Grantová agentura ČR, Vztah struktury a funkce v signálováni fibroblastových růstových faktorů, Lead agentura

LX22NPO5102, projekt VaV

Název: Národní ústav pro výzkum rakoviny (Akronym: NÚVR)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro výzkum rakoviny, 5.1 EXCELES

Citovat

KRZYSCIK, Mateusz A, Kelly KARL, Pooja DUDEJA, Pavel KREJČÍ a Kalina HRISTOVA. Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands. CYTOKINE & GROWTH FACTOR REVIEWS. London: ELSEVIER SCI LTD, 2024, roč. 78, August 2024, s. 77-84. ISSN 1359-6101. Dostupné z: https://dx.doi.org/10.1016/j.cytogfr.2024.07.002.

@article{2430461,
   author = {Krzyscik, Mateusz A and Karl, Kelly and Dudeja, Pooja and Krejčí, Pavel and Hristova, Kalina},
   article_location = {London},
   article_number = {August 2024},
   doi = {http://dx.doi.org/10.1016/j.cytogfr.2024.07.002},
   keywords = {FGF; FGFR; Signaling; Bias},
   language = {eng},
   issn = {1359-6101},
   journal = {CYTOKINE & GROWTH FACTOR REVIEWS},
   title = {Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands},
   url = {https://www.sciencedirect.com/science/article/pii/S1359610124000443?via%3Dihub},
   volume = {78},
   year = {2024}
}

TY  - JOUR
ID  - 2430461
AU  - Krzyscik, Mateusz A - Karl, Kelly - Dudeja, Pooja - Krejčí, Pavel - Hristova, Kalina
PY  - 2024
TI  - Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands
JF  - CYTOKINE & GROWTH FACTOR REVIEWS
VL  - 78
IS  - August 2024
SP  - 77-84
EP  - 77-84
PB  - ELSEVIER SCI LTD
SN  - 13596101
KW  - FGF
KW  - FGFR
KW  - Signaling
KW  - Bias
UR  - https://www.sciencedirect.com/science/article/pii/S1359610124000443?via%3Dihub
N2  - The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tissue, different FGFs can trigger dramatically different biological responses via this receptor. Here we show both quantitative and qualitative differences in the signaling of one of the FGF receptors, FGFR1c, in response to different FGFs. We provide an overview of the recent discovery that FGFs engage in biased signaling via FGFR1c. We discuss the concept of ligand bias, which represents qualitative differences in signaling as it is a measure of differential ligand preferences for different downstream responses. We show how FGF ligand bias manifests in functional data in cultured chondrocyte cells. We argue that FGF-ligand bias contributes substantially to FGF-driven developmental processes, along with known differences in FGF expression levels, FGF-FGFR binding coefficients and differences in FGF stability in vivo.
ER  -

KRZYSCIK, Mateusz A, Kelly KARL, Pooja DUDEJA, Pavel KREJČÍ a Kalina HRISTOVA. Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands. \textit{CYTOKINE \&{} GROWTH FACTOR REVIEWS}. London: ELSEVIER SCI LTD, 2024, roč.~78, August 2024, s.~77-84. ISSN~1359-6101. Dostupné z: https://dx.doi.org/10.1016/j.cytogfr.2024.07.002.

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