ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION
FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN
VENTRICULAR CARDIOMYOCYTE

D 2024

ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

PÁSEK, Michal; Markéta BÉBAROVÁ a G, CHRISTÉ

Základní údaje

Originální název

ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Autoři

PÁSEK, Michal; Markéta BÉBAROVÁ a G, CHRISTÉ

Vydání

Prague, ENGINEERING MECHANICS: 30th INTERNATIONAL CONFERENCE May 14 – 16, 2024, Milovy, Czech Republic, od s. 230-233, 4 s. 2024

Nakladatel

Institute of Thermomechanics, Academy of Sciences of the Czech Republic

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00139960

Organizační jednotka

Lékařská fakulta

ISBN

978-80-214-6235-9

ISSN

Klíčová slova anglicky

human ventricular cardiomyocyte; t-tubules; submembrane spaces; submembrane Ca2+ gradient; Na+ -Ca2+ exchanger; mathematical model

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 3. 2025 13:45, Mgr. Tereza Miškechová

Anotace

V originále

We have recently developed a model of human ventricular cardiomyocyte incorporating the t-tubular and surface submembrane spaces and restricted ion exchange between these spaces and cytosol. After incorporating the experimental finding that majority of Na+ -Ca2+ exchanger proteins are located at the t-tubular membrane of human ventricular cardiomyocytes, we explored the consequences of ion concentration changes in the submembrane spaces on the electrophysiological activity of these cells. Consistently with the experimental and modelling studies published so far, our model predicts an increased Ca2+ extrusion during the action potential. However, our model also predicts a significant reduction of Ca2+ extrusion throughout the diastole, which can ultimately lead to an increase of cellular inotropy.

Návaznosti

NU22-02-00348, projekt VaV

Název: Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus

Investor: Ministerstvo zdravotnictví ČR, Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus, Podprogram 1 - standardní

Citovat

PÁSEK, Michal; Markéta BÉBAROVÁ a G, CHRISTÉ. ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE. In Vladimír Fuis; Petr Hájek. ENGINEERING MECHANICS: 30th INTERNATIONAL CONFERENCE May 14 – 16, 2024, Milovy, Czech Republic. Prague: Institute of Thermomechanics, Academy of Sciences of the Czech Republic, 2024, s. 230-233. ISBN 978-80-214-6235-9.

@inproceedings{2434561,
   author = {Pásek, Michal and Bébarová, Markéta and Christé, G,},
   address = {Prague},
   booktitle = {ENGINEERING MECHANICS: 30th INTERNATIONAL CONFERENCE May 14 – 16, 2024, Milovy, Czech Republic},
   editor = {Vladimír Fuis; Petr Hájek},
   keywords = {human ventricular cardiomyocyte; t-tubules; submembrane spaces; submembrane Ca2+ gradient; Na+ -Ca2+ exchanger; mathematical model},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Prague},
   isbn = {978-80-214-6235-9},
   pages = {230-233},
   publisher = {Institute of Thermomechanics, Academy of Sciences of the Czech Republic},
   title = {ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE},
   url = {https://www.engmech.cz/improc/2024/230.pdf},
   year = {2024}
}

TY  - CONF
ID  - 2434561
AU  - Pásek, Michal - Bébarová, Markéta - Christé, G,
PY  - 2024
TI  - ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE
PB  - Institute of Thermomechanics, Academy of Sciences of the Czech Republic
CY  - Prague
SN  - 9788021462359
KW  - human ventricular cardiomyocyte
KW  - t-tubules
KW  - submembrane spaces
KW  - submembrane Ca2+ gradient
KW  - Na+ -Ca2+ exchanger
KW  - mathematical model
UR  - https://www.engmech.cz/improc/2024/230.pdf
N2  - We have recently developed a model of human ventricular cardiomyocyte incorporating the t-tubular and surface submembrane spaces and restricted ion exchange between these spaces and cytosol. After incorporating the experimental finding that majority of Na+ -Ca2+ exchanger proteins are located at the t-tubular membrane of human ventricular cardiomyocytes, we explored the consequences of ion concentration changes in the submembrane spaces on the electrophysiological activity of these cells. Consistently with the experimental and modelling studies published so far, our model predicts an increased Ca2+ extrusion during the action potential. However, our model also predicts a significant reduction of Ca2+ extrusion throughout the diastole, which can ultimately lead to an increase of cellular inotropy.
ER  -

PÁSEK, Michal; Markéta BÉBAROVÁ a G, CHRISTÉ. ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE. In Vladimír Fuis; Petr Hájek. \textit{ENGINEERING MECHANICS: 30th INTERNATIONAL CONFERENCE May 14 – 16, 2024, Milovy, Czech Republic}. Prague: Institute of Thermomechanics, Academy of Sciences of the Czech Republic, 2024, s.~230-233. ISBN~978-80-214-6235-9.

Přehled o publikaci