Loss of normal facial asymmetry in schizophrenia and bipolar
disorder: Implications for development of brain asymmetry in
psychotic illness

J 2024

Loss of normal facial asymmetry in schizophrenia and bipolar disorder: Implications for development of brain asymmetry in psychotic illness

SUKNO, Federico M.; Brendan D. KELLY; Abbie LANE; Stanislav KATINA; Mario A. ROJAS et al.

Základní údaje

Originální název

Loss of normal facial asymmetry in schizophrenia and bipolar disorder: Implications for development of brain asymmetry in psychotic illness

Autoři

SUKNO, Federico M.; Brendan D. KELLY; Abbie LANE; Stanislav KATINA; Mario A. ROJAS; Paul F. WHELAN a John L. WADDINGTON

Vydání

Psychiatry Research, Elsevier Ltd. 2024, 0165-1781

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30215 Psychiatry

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00137216

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Psychosis; Neurodevelopment; Craniofacies; Frontal lobes; 3D Laser surface imaging; Geometric morphometrics

Štítky

14311010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 1. 2025 07:52, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Development of the craniofacies occurs in embryological intimacy with development of the brain and both show normal left-right asymmetries. While facial dysmorphology occurs to excess in psychotic illness, facial asymmetry has yet to be investigated as a putative index of brain asymmetry. Ninety-three subjects (49 controls, 22 schizophrenia, 22 bipolar disorder) received 3D laser surface imaging of the face. On geometric morphometric analysis with (x, y, z) visualisations of statistical models for facial asymmetries, in controls the upper face and periorbital region, which share embryological intimacy with the forebrain, showed marked asymmetries. Their geometry included: along the x-axis, rightward asymmetry in its dorsal-medial aspects and leftward asymmetry in its ventral-lateral aspects; along the z-axis, anterior protrusion in its right ventral-lateral aspect. In both schizophrenia and bipolar disorder these normal facial asymmetries were diminished, with residual retention of asymmetries in bipolar disorder. This geometry of normal facial asymmetries shows commonalities with that of normal frontal lobe asymmetries. These findings indicate a trans-diagnostic process that involves loss of facial asymmetries in both schizophrenia and bipolar disorder. Embryologically, they implicate loss of face-brain asymmetries across gestational weeks 7–14 in processes that involve genes previously associated with risk for schizophrenia.

Citovat

SUKNO, Federico M.; Brendan D. KELLY; Abbie LANE; Stanislav KATINA; Mario A. ROJAS; Paul F. WHELAN a John L. WADDINGTON. Loss of normal facial asymmetry in schizophrenia and bipolar disorder: Implications for development of brain asymmetry in psychotic illness. Psychiatry Research. Elsevier Ltd., 2024, roč. 342, December 2024, s. 1-8. ISSN 0165-1781. Dostupné z: https://doi.org/10.1016/j.psychres.2024.116213.

@article{2437539,
   author = {Sukno, Federico M. and Kelly, Brendan D. and Lane, Abbie and Katina, Stanislav and Rojas, Mario A. and Whelan, Paul F. and Waddington, John L.},
   article_number = {December 2024},
   doi = {https://doi.org/10.1016/j.psychres.2024.116213},
   keywords = {Psychosis; Neurodevelopment; Craniofacies; Frontal lobes; 3D Laser surface imaging; Geometric morphometrics},
   language = {eng},
   issn = {0165-1781},
   journal = {Psychiatry Research},
   title = {Loss of normal facial asymmetry in schizophrenia and bipolar disorder: Implications for development of brain asymmetry in psychotic illness},
   url = {https://www.sciencedirect.com/science/article/pii/S0165178124004980?via%3Dihub},
   volume = {342},
   year = {2024}
}

TY  - JOUR
ID  - 2437539
AU  - Sukno, Federico M. - Kelly, Brendan D. - Lane, Abbie - Katina, Stanislav - Rojas, Mario A. - Whelan, Paul F. - Waddington, John L.
PY  - 2024
TI  - Loss of normal facial asymmetry in schizophrenia and bipolar disorder: Implications for development of brain asymmetry in psychotic illness
JF  - Psychiatry Research
VL  - 342
IS  - December 2024
SP  - 1-8
EP  - 1-8
PB  - Elsevier Ltd.
SN  - 01651781
KW  - Psychosis
KW  - Neurodevelopment
KW  - Craniofacies
KW  - Frontal lobes
KW  - 3D Laser surface imaging
KW  - Geometric morphometrics
UR  - https://www.sciencedirect.com/science/article/pii/S0165178124004980?via%3Dihub
N2  - Development of the craniofacies occurs in embryological intimacy with development of the brain and both show normal left-right asymmetries. While facial dysmorphology occurs to excess in psychotic illness, facial asymmetry has yet to be investigated as a putative index of brain asymmetry. Ninety-three subjects (49 controls, 22 schizophrenia, 22 bipolar disorder) received 3D laser surface imaging of the face. On geometric morphometric analysis with (x, y, z) visualisations of statistical models for facial asymmetries, in controls the upper face and periorbital region, which share embryological intimacy with the forebrain, showed marked asymmetries. Their geometry included: along the x-axis, rightward asymmetry in its dorsal-medial aspects and leftward asymmetry in its ventral-lateral aspects; along the z-axis, anterior protrusion in its right ventral-lateral aspect. In both schizophrenia and bipolar disorder these normal facial asymmetries were diminished, with residual retention of asymmetries in bipolar disorder. This geometry of normal facial asymmetries shows commonalities with that of normal frontal lobe asymmetries. These findings indicate a trans-diagnostic process that involves loss of facial asymmetries in both schizophrenia and bipolar disorder. Embryologically, they implicate loss of face-brain asymmetries across gestational weeks 7–14 in processes that involve genes previously associated with risk for schizophrenia.
ER  -

SUKNO, Federico M.; Brendan D. KELLY; Abbie LANE; Stanislav KATINA; Mario A. ROJAS; Paul F. WHELAN a John L. WADDINGTON. Loss of normal facial asymmetry in schizophrenia and bipolar disorder: Implications for development of brain asymmetry in psychotic illness. \textit{Psychiatry Research}. Elsevier Ltd., 2024, roč.~342, December 2024, s.~1-8. ISSN~0165-1781. Dostupné z: https://doi.org/10.1016/j.psychres.2024.116213.

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