2024
In vitro study of materials for functional replacements in nerve tissue regeneration
ZAMANI, Alemeh; K KOCOURKOVÁ; M KADLEČKOVÁ; F MIKULKA; R MINAŘÍKOVÁ et al.Základní údaje
Originální název
In vitro study of materials for functional replacements in nerve tissue regeneration
Název anglicky
In vitro study of materials for functional replacements in nerve tissue regeneration
Autoři
ZAMANI, Alemeh ORCID; K KOCOURKOVÁ; M KADLEČKOVÁ; F MIKULKA; R MINAŘÍKOVÁ; P SMOLKA; Anna RÁBOVÁ ORCID; Parisa EMAMIAREF; Lucie KUBÍČKOVÁ; Klaudia HAŠANOVÁ; Marek JOUKAL a A MINAŘÍK
Vydání
Morphology 2024, 2024
Další údaje
Typ výsledku
Prezentace na konferencích
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Označené pro přenos do RIV
Ne
DOI
Změněno: 1. 10. 2024 08:42, Alemeh Zamani, Ph.D.
Anotace
Anglicky
Sciatic nerve injuries pose a significant clinical challenge, often resulting in severe functional impairment and reduced quality of life. Precise 3D printing fabrication of scaffolds that replicate the complex architecture of native nerve tissue emerges as a promising solution for further nerve tissue regeneration. Schwann cells play a crucial role in supporting neurons by promoting axonal growth and facilitating myelination, which is essential for effective nerve regeneration. This study focuses on printable polymer-based biocompatible materials, enabling Schwann cell adhesion, proliferation, and differentiation in vitro. The growth of cells and the extension of cell processes were evaluated using immunocytochemistry for beta-actin. Among the tested materials, the initial synthetic biocompatible material demonstrated low cell adhesion, resulting in poor cell viability on the surface. In contrast, the enhanced composite scaffolds seem to be more suitable, supporting better cell growth and cell process extension. Our results provide a platform of suitable materials for the growth of Schwann cells. These findings offer a promising foundation for further research and development of complex conduits for nerve tissue regeneration.
Návaznosti
| NU23-08-00243, projekt VaV |
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