GEISSLER, Klaus, Zdenek KORISTEK, del Castillo Teresa BERNAL, Jan NOVAK, Gabriela RODRIGUEZ-MACIAS, Stephan K METZELDER, Arpad ILLES, Jiří MAYER, Montserrat ARNAN, Mary-Margaret KEATING, Juergen KRAUTER, Monia LUNGHI, Nicola Stefano FRACCHIOLLA, Uwe PLATZBECKER, Valeria SANTINI, Yuri SANO, Aram OGANESIAN, Harold KEER a Michael LUEBBERT. Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study. British journal of haematology. Hoboken: Wiley-Blackwell, 2024, s. 1-12. ISSN 0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.19741. |
Další formáty:
BibTeX
LaTeX
RIS
@article{2439078, author = {Geissler, Klaus and Koristek, Zdenek and Bernal, del Castillo Teresa and Novak, Jan and RodriguezandMacias, Gabriela and Metzelder, Stephan K and Illes, Arpad and Mayer, Jiří and Arnan, Montserrat and Keating, MaryandMargaret and Krauter, Juergen and Lunghi, Monia and Fracchiolla, Nicola Stefano and Platzbecker, Uwe and Santini, Valeria and Sano, Yuri and Oganesian, Aram and Keer, Harold and Luebbert, Michael}, article_location = {Hoboken}, doi = {http://dx.doi.org/10.1111/bjh.19741}, keywords = {acute myeloid leukaemia; decitabine/cedazuridine; DNA methyltransferase inhibitors; hypomethylating agents; somatic mutations}, language = {eng}, issn = {0007-1048}, journal = {British journal of haematology}, title = {Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study}, url = {https://onlinelibrary.wiley.com/doi/10.1111/bjh.19741}, year = {2024} }
TY - JOUR ID - 2439078 AU - Geissler, Klaus - Koristek, Zdenek - Bernal, del Castillo Teresa - Novak, Jan - Rodriguez-Macias, Gabriela - Metzelder, Stephan K - Illes, Arpad - Mayer, Jiří - Arnan, Montserrat - Keating, Mary-Margaret - Krauter, Juergen - Lunghi, Monia - Fracchiolla, Nicola Stefano - Platzbecker, Uwe - Santini, Valeria - Sano, Yuri - Oganesian, Aram - Keer, Harold - Luebbert, Michael PY - 2024 TI - Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study JF - British journal of haematology SP - 1-12 EP - 1-12 PB - Wiley-Blackwell SN - 00071048 KW - acute myeloid leukaemia KW - decitabine/cedazuridine KW - DNA methyltransferase inhibitors KW - hypomethylating agents KW - somatic mutations UR - https://onlinelibrary.wiley.com/doi/10.1111/bjh.19741 N2 - This study compared decitabine exposure when administered IV (DEC-IV) at a dose of 20 mg/m(2) for 5-days with orally administered decitabine with cedazuridine (DEC-C), as well as the clinical efficacy and safety of DEC-C in patients with acute myeloid leukaemia (AML) who were ineligible for intensive induction chemotherapy. In all, 89 patients were randomised 1:1 to DEC-IV or oral DEC-C (days 1-5 in a 28-day treatment cycle), followed by 5 days of the other formulation in the next treatment cycle. All patients received oral DEC-C for subsequent treatment cycles until treatment discontinuation. Equivalent systemic decitabine exposures were demonstrated (5-day area under the curve ratio between the two decitabine formulations of 99.64 [90% confidence interval 91.23%, 108.80%]). Demethylation rates also were similar (<= 1.1% difference). Median overall survival (OS), clinical response and safety profile with oral DEC-C were consistent with those previously observed with DEC-IV. Next-generation sequencing was performed to identify molecular abnormalities that impact OS and TP53 mutations were associated with a poor outcome. These findings support the use of oral DEC-C in patients with AML. ER -
GEISSLER, Klaus, Zdenek KORISTEK, del Castillo Teresa BERNAL, Jan NOVAK, Gabriela RODRIGUEZ-MACIAS, Stephan K METZELDER, Arpad ILLES, Jiří MAYER, Montserrat ARNAN, Mary-Margaret KEATING, Juergen KRAUTER, Monia LUNGHI, Nicola Stefano FRACCHIOLLA, Uwe PLATZBECKER, Valeria SANTINI, Yuri SANO, Aram OGANESIAN, Harold KEER a Michael LUEBBERT. Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study. \textit{British journal of haematology}. Hoboken: Wiley-Blackwell, 2024, s.~1-12. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.19741.
|