Disruption of Lipid Profile, Glucose Metabolism, and Leptin
Levels following Citalopram Administration and
High-Carbohydrate and High-Cholesterol Diet in Mice

J 2024

Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice

HAMMER, Tomáš; Hana KOTOLOVÁ; Jiří PROCHÁZKA a Michal KARPÍŠEK

Základní údaje

Originální název

Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice

Autoři

HAMMER, Tomáš; Hana KOTOLOVÁ; Jiří PROCHÁZKA a Michal KARPÍŠEK

Vydání

PHARMACOLOGY, BASEL, KARGER, 2024, 0031-7012

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.200

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/24:00137387

Organizační jednotka

Farmaceutická fakulta

Klíčová slova anglicky

Adipokines; Citalopram; Dyslipidemia; Leptin; Metabolic syndrome; Mouse

Štítky

rivok, ÚFTo

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 4. 2025 10:43, Mgr. Natálie Hílek

Anotace

V originále

Introduction: Depression therapy has been linked to negative effects on energy metabolism, which can be attributed to various factors, including an ongoing inflammatory process commonly seen in metabolic disorders. Unhealthy lifestyle choices of patients and the impact of antidepressants on body weight and lipid and glucose metabolism also contribute to these metabolic side effects. Although not as pronounced as other psychopharmaceuticals, the increasing use of antidepressants raises concerns about their potential impact on public health. The study aimed to evaluate the short- and long-term effects of the antidepressant citalopram and its long-term combination with a special diet on metabolic parameters in mice. Methods: Animals were randomly divided into 5 groups - control, control + special diet, citalopram (10 mg/kg for 35 days), citalopram + special diet (10 mg/kg for 35 days), and citalopram (10 mg/kg for 7 days). After a described time of administration, animals were anesthetized, blood and fat and liver tissues were collected. Biochemical parameters of lipid metabolism (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) and glucose were analyzed using spectrophotometry and relevant adipokines and cytokines were evaluated by ELISA. Results: After a week of application of citalopram, we observed dyslipidemia that persisted even at the end of the 5-week experiment. Furthermore, after 5 weeks of citalopram administration, we observed a significant decrease in body weight gain and decreased leptin levels. Changes in lipid metabolism, higher levels of adipokines leptin and PAI-1 were observed due to the special diet after 5 weeks. Conclusions: Our research suggests that the effects of citalopram and a diet on the metabolism of mice can be significant, both in the short term (1 week) and in the long term (5 weeks).

Citovat

HAMMER, Tomáš; Hana KOTOLOVÁ; Jiří PROCHÁZKA a Michal KARPÍŠEK. Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice. PHARMACOLOGY. BASEL: KARGER, 2024, Neuveden, Neuvedeno, s. 1-11. ISSN 0031-7012. Dostupné z: https://doi.org/10.1159/000541229.

@article{2445479,
   author = {Hammer, Tomáš and Kotolová, Hana and Procházka, Jiří and Karpíšek, Michal},
   article_location = {BASEL},
   article_number = {Neuvedeno},
   doi = {https://doi.org/10.1159/000541229},
   keywords = {Adipokines; Citalopram; Dyslipidemia; Leptin; Metabolic syndrome; Mouse},
   language = {eng},
   issn = {0031-7012},
   journal = {PHARMACOLOGY},
   title = {Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice},
   url = {https://karger.com/pha/article-pdf/doi/10.1159/000541229/4283067/000541229.pdf},
   volume = {Neuveden},
   year = {2024}
}

TY  - JOUR
ID  - 2445479
AU  - Hammer, Tomáš - Kotolová, Hana - Procházka, Jiří - Karpíšek, Michal
PY  - 2024
TI  - Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice
JF  - PHARMACOLOGY
VL  - Neuveden
IS  - Neuvedeno
SP  - 1-11
EP  - 1-11
PB  - KARGER
SN  - 00317012
KW  - Adipokines
KW  - Citalopram
KW  - Dyslipidemia
KW  - Leptin
KW  - Metabolic syndrome
KW  - Mouse
UR  - https://karger.com/pha/article-pdf/doi/10.1159/000541229/4283067/000541229.pdf
N2  - Introduction: Depression therapy has been linked to negative effects on energy metabolism, which can be attributed to various factors, including an ongoing inflammatory process commonly seen in metabolic disorders. Unhealthy lifestyle choices of patients and the impact of antidepressants on body weight and lipid and glucose metabolism also contribute to these metabolic side effects. Although not as pronounced as other psychopharmaceuticals, the increasing use of antidepressants raises concerns about their potential impact on public health. The study aimed to evaluate the short- and long-term effects of the antidepressant citalopram and its long-term combination with a special diet on metabolic parameters in mice. Methods: Animals were randomly divided into 5 groups - control, control + special diet, citalopram (10 mg/kg for 35 days), citalopram + special diet (10 mg/kg for 35 days), and citalopram (10 mg/kg for 7 days). After a described time of administration, animals were anesthetized, blood and fat and liver tissues were collected. Biochemical parameters of lipid metabolism (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) and glucose were analyzed using spectrophotometry and relevant adipokines and cytokines were evaluated by ELISA. Results: After a week of application of citalopram, we observed dyslipidemia that persisted even at the end of the 5-week experiment. Furthermore, after 5 weeks of citalopram administration, we observed a significant decrease in body weight gain and decreased leptin levels. Changes in lipid metabolism, higher levels of adipokines leptin and PAI-1 were observed due to the special diet after 5 weeks. Conclusions: Our research suggests that the effects of citalopram and a diet on the metabolism of mice can be significant, both in the short term (1 week) and in the long term (5 weeks).
ER  -

HAMMER, Tomáš; Hana KOTOLOVÁ; Jiří PROCHÁZKA a Michal KARPÍŠEK. Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice. \textit{PHARMACOLOGY}. BASEL: KARGER, 2024, Neuveden, Neuvedeno, s.~1-11. ISSN~0031-7012. Dostupné z: https://doi.org/10.1159/000541229.

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