Differentiation of solid and friable tumour thrombus in
patients with renal cell carcinoma: The role of MRI apparent
diffusion coefficient

J 2024

Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient

KOWAL, Pawel; Krzysztof RATAJCZYK; Wiktor BURSIEWICZ; Maciej TRZCINIECKI; Karolina MAREK-BUKOWIEC et al.

Základní údaje

Originální název

Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient

Autoři

KOWAL, Pawel; Krzysztof RATAJCZYK; Wiktor BURSIEWICZ; Maciej TRZCINIECKI; Karolina MAREK-BUKOWIEC; Joanna ROGALA; Vasyl KOWALSKYI; Jozef DRAGASEK; Andrea BOTIKOVA; Peter KRUŽLIAK a Yulian MYTSYK

Vydání

Advances in Medical Sciences, WROCLAW, ELSEVIER URBAN & PARTNER SP Z O O, 2024, 1896-1126

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00137416

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Renal cell carcinoma; Thrombus; Diffusion-weighted imaging; Texture analysis

Štítky

14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 10. 2024 09:16, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: Inferior vena cava (IVC) involvement by renal cell carcinoma (RCC) is associated with a higher disease stage and is considered a risk factor for poor prognosis. This study aimed to investigate the role of the apparent diffusion coefficient (ADC) of MRI 3D texture analysis in the differentiation of solid and friable tumour thrombus in patients with RCC. Materials and methods: The study involved 27 patients with RCC with tumour thrombus in the renal vein or IVC, surgically treated with nephrectomy and thrombectomy and in whom preoperatively abdominal MRI including the DWI sequence was conducted. For 3D texture analysis, the ADC map was used, and the first-order radiomic features were calculated from the whole volume of the thrombus. All tumour thrombi were histologically classified as solid or friable. Results: The solid and friable thrombus was detected in 51.9% and 48.1 % of patients, respectively. No differences in mean values of range, 90th percentile, interquartile range, kurtosis, uniformity and variance were found between groups. Equal sensitivity and specificity (93 % and 69%, respectively) of ADC mean, median and entropy in differentiation between solid and friable tumour thrombus, with the highest AUC for entropy (0.808), were observed. Applying the skewness threshold value of 0.09 allowed us to achieve a sensitivity of 86 % and a specificity of 92 %. Conclusions: In patients with RCC and tumour thrombus in the renal vein or IVC, the 3D texture analysis based on ADC-map allows for precise differentiation of a solid from a friable thrombus.

Citovat

KOWAL, Pawel; Krzysztof RATAJCZYK; Wiktor BURSIEWICZ; Maciej TRZCINIECKI; Karolina MAREK-BUKOWIEC; Joanna ROGALA; Vasyl KOWALSKYI; Jozef DRAGASEK; Andrea BOTIKOVA; Peter KRUŽLIAK a Yulian MYTSYK. Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient. Advances in Medical Sciences. WROCLAW: ELSEVIER URBAN & PARTNER SP Z O O, 2024, roč. 69, č. 2, s. 434-442. ISSN 1896-1126. Dostupné z: https://doi.org/10.1016/j.advms.2024.09.002.

@article{2446190,
   author = {Kowal, Pawel and Ratajczyk, Krzysztof and Bursiewicz, Wiktor and Trzciniecki, Maciej and MarekandBukowiec, Karolina and Rogala, Joanna and Kowalskyi, Vasyl and Dragasek, Jozef and Botikova, Andrea and Kružliak, Peter and Mytsyk, Yulian},
   article_location = {WROCLAW},
   article_number = {2},
   doi = {https://doi.org/10.1016/j.advms.2024.09.002},
   keywords = {Renal cell carcinoma; Thrombus; Diffusion-weighted imaging; Texture analysis},
   language = {eng},
   issn = {1896-1126},
   journal = {Advances in Medical Sciences},
   title = {Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient},
   url = {https://www.sciencedirect.com/science/article/pii/S1896112624000506?via%3Dihub},
   volume = {69},
   year = {2024}
}

TY  - JOUR
ID  - 2446190
AU  - Kowal, Pawel - Ratajczyk, Krzysztof - Bursiewicz, Wiktor - Trzciniecki, Maciej - Marek-Bukowiec, Karolina - Rogala, Joanna - Kowalskyi, Vasyl - Dragasek, Jozef - Botikova, Andrea - Kružliak, Peter - Mytsyk, Yulian
PY  - 2024
TI  - Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient
JF  - Advances in Medical Sciences
VL  - 69
IS  - 2
SP  - 434-442
EP  - 434-442
PB  - ELSEVIER URBAN & PARTNER SP Z O O
SN  - 18961126
KW  - Renal cell carcinoma
KW  - Thrombus
KW  - Diffusion-weighted imaging
KW  - Texture analysis
UR  - https://www.sciencedirect.com/science/article/pii/S1896112624000506?via%3Dihub
N2  - Purpose: Inferior vena cava (IVC) involvement by renal cell carcinoma (RCC) is associated with a higher disease stage and is considered a risk factor for poor prognosis. This study aimed to investigate the role of the apparent diffusion coefficient (ADC) of MRI 3D texture analysis in the differentiation of solid and friable tumour thrombus in patients with RCC. Materials and methods: The study involved 27 patients with RCC with tumour thrombus in the renal vein or IVC, surgically treated with nephrectomy and thrombectomy and in whom preoperatively abdominal MRI including the DWI sequence was conducted. For 3D texture analysis, the ADC map was used, and the first-order radiomic features were calculated from the whole volume of the thrombus. All tumour thrombi were histologically classified as solid or friable. Results: The solid and friable thrombus was detected in 51.9% and 48.1 % of patients, respectively. No differences in mean values of range, 90th percentile, interquartile range, kurtosis, uniformity and variance were found between groups. Equal sensitivity and specificity (93 % and 69%, respectively) of ADC mean, median and entropy in differentiation between solid and friable tumour thrombus, with the highest AUC for entropy (0.808), were observed. Applying the skewness threshold value of 0.09 allowed us to achieve a sensitivity of 86 % and a specificity of 92 %. Conclusions: In patients with RCC and tumour thrombus in the renal vein or IVC, the 3D texture analysis based on ADC-map allows for precise differentiation of a solid from a friable thrombus.
ER  -

KOWAL, Pawel; Krzysztof RATAJCZYK; Wiktor BURSIEWICZ; Maciej TRZCINIECKI; Karolina MAREK-BUKOWIEC; Joanna ROGALA; Vasyl KOWALSKYI; Jozef DRAGASEK; Andrea BOTIKOVA; Peter KRUŽLIAK a Yulian MYTSYK. Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient. \textit{Advances in Medical Sciences}. WROCLAW: ELSEVIER URBAN \&{} PARTNER SP Z O O, 2024, roč.~69, č.~2, s.~434-442. ISSN~1896-1126. Dostupné z: https://doi.org/10.1016/j.advms.2024.09.002.

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