Circulating plasma cells in multiple myeloma

a 2024

Circulating plasma cells in multiple myeloma

RŮŽIČKOVÁ, Tereza; Monika VLACHOVÁ; Jana KOTAŠKOVÁ; Martina ALMÁŠI; Lucie ŘÍHOVÁ et al.

Základní údaje

Originální název

Circulating plasma cells in multiple myeloma

Název česky

Cirkulující plazmatické buňky u mnohočetného myelomu

Název anglicky

Circulating plasma cells in multiple myeloma

Autoři

RŮŽIČKOVÁ, Tereza ; Monika VLACHOVÁ; Jana KOTAŠKOVÁ; Martina ALMÁŠI; Lucie ŘÍHOVÁ; Martin ŠTORK; Luděk POUR a Sabina ŠEVČÍKOVÁ

Vydání

III. Český hematologický a transfuziologický sjezd, 2024

Další údaje

Typ výsledku

Konferenční abstrakt

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

UT WoS

000736398802087

Změněno: 20. 10. 2025 14:25, Mgr. Petra Trembecká, Ph.D.

Anotace

V originále

Multiple myeloma (MM) is a hemato-oncological disease characterized by abnormal plasma cell (PCs) proliferation. In MM, these PCs proliferate within the bone marrow, leading to bone destruction, bone marrow failure, and the secretion of abnormal proteins into the bloodstream. However, in some cases of MM, these PCs can escape from the bone marrow microenvironment and enter the bloodstream. The presence of circulating PCs (cPCs) in peripheral blood is considered a sign of advanced or aggressive disease. It may also indicate disease progression or relapse in patients who have previously undergone treatment. We investigated differences in microRNA (miRNA) expression between bone marrow plasma cells (BMPCs) and cPCs of MM patients. Samples of BMPCs (N = 33) and cPCs (N = 13) were subjected to next generation sequencing, enabling comprehensive profiling of miRNA expression patterns. Our analysis revealed four significantly (P < 0.0000000001) differentially expressed miRNAs between BMPCs and cPCs. These findings suggest distinct molecular profiles between BMPCs and cPCs, indicating potential differences in the regulatory mechanisms underlying MM progression at different anatomical sites. Further exploration of these miRNAs may unveil their roles in MM pathogenesis and offer new potential therapeutic targets or biomarkers

Citovat

RŮŽIČKOVÁ, Tereza; Monika VLACHOVÁ; Jana KOTAŠKOVÁ; Martina ALMÁŠI; Lucie ŘÍHOVÁ; Martin ŠTORK; Luděk POUR a Sabina ŠEVČÍKOVÁ. Circulating plasma cells in multiple myeloma. In III. Český hematologický a transfuziologický sjezd. 2024.

@proceedings{2453008,
   author = {Růžičková, Tereza and Vlachová, Monika and Kotašková, Jana and Almáši, Martina and Říhová, Lucie and Štork, Martin and Pour, Luděk and Ševčíková, Sabina},
   booktitle = {III. Český hematologický a transfuziologický sjezd},
   title = {Circulating plasma cells in multiple myeloma},
   url = {https://7159d81c4f.clvaw-cdnwnd.com/d9a86278a680d42254a20a397f437dc6/200000156-db618db61b/TAHD%202024-sborn%C3%ADk_abstrakt.pdf?ph=7159d81c4f},
   year = {2024}
}

TY  - CONF
ID  - 2453008
AU  - Růžičková, Tereza - Vlachová, Monika - Kotašková, Jana - Almáši, Martina - Říhová, Lucie - Štork, Martin - Pour, Luděk - Ševčíková, Sabina
PY  - 2024
TI  - Circulating plasma cells in multiple myeloma
UR  - https://7159d81c4f.clvaw-cdnwnd.com/d9a86278a680d42254a20a397f437dc6/200000156-db618db61b/TAHD%202024-sborn%C3%ADk_abstrakt.pdf?ph=7159d81c4f
N2  - Multiple myeloma (MM) is a hemato-oncological disease characterized by abnormal plasma cell (PCs) proliferation. In MM, these PCs proliferate within the bone marrow, leading to bone destruction, bone marrow failure, and the secretion of abnormal proteins into the bloodstream. However, in some cases of MM, these PCs can escape from the bone marrow microenvironment and enter the bloodstream. The presence of circulating PCs (cPCs) in peripheral blood is considered a sign of advanced or aggressive disease. It may also indicate disease progression or relapse in patients who have previously undergone treatment. We investigated differences in microRNA (miRNA) expression between bone marrow plasma cells (BMPCs) and cPCs of MM patients. Samples of BMPCs (N = 33) and cPCs (N = 13) were subjected to next generation sequencing, enabling comprehensive profiling of miRNA expression patterns. Our analysis revealed four significantly (P < 0.0000000001) differentially expressed miRNAs between BMPCs and cPCs. These findings suggest distinct molecular profiles between BMPCs and cPCs, indicating potential differences in the regulatory mechanisms underlying MM progression at different anatomical sites. Further exploration of these miRNAs may unveil their roles in MM pathogenesis and offer new potential therapeutic targets or biomarkers
ER  -

RŮŽIČKOVÁ, Tereza; Monika VLACHOVÁ; Jana KOTAŠKOVÁ; Martina ALMÁŠI; Lucie ŘÍHOVÁ; Martin ŠTORK; Luděk POUR a Sabina ŠEVČÍKOVÁ. Circulating plasma cells in multiple myeloma. In \textit{III. Český hematologický a transfuziologický sjezd}. 2024.

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