Vitamin D in blood serum and chronic pancreatitis

J 2024

Vitamin D in blood serum and chronic pancreatitis

PŘECECHTĚLOVÁ, Marie; Petr DÍTĚ; Dana BUČKOVÁ; Martina BOJKOVA; Bohuslav KIANIČKA et al.

Základní údaje

Originální název

Vitamin D in blood serum and chronic pancreatitis

Autoři

PŘECECHTĚLOVÁ, Marie; Petr DÍTĚ; Dana BUČKOVÁ; Martina BOJKOVA; Bohuslav KIANIČKA; David SOLIL a Jiří DOLINA

Vydání

Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2024, 0006-9248

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00137796

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

chronic pancreatitis; exocrine pancreatic insufficiency; pancreatic fibrosis; vitamin D; vitamin D supplementation

Štítky

14110116, 14110213, 14110616, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 11. 2024 08:24, Mgr. Tereza Miškechová

Anotace

V originále

Patients with chronic pancreatitis are at risk of developing malabsorption and malnutrition. Exocrine pancreatic insufficiency is accompanied by decreased serum micronutrient levels and low vitamin D levels are a frequent finding in up to 60-80% of patients. The aim of our prospective study was to investigate vitamin D in the blood serum of subjects with chronic pancreatitis with the possibility of influencing the reduced vitamin D levels with supplementation therapy. MATERIAL AND METHODOLOGY: Fifty patients with chronic pancreatitis and 20 subjects in the control group without gastrointestinal tract diseases, including pancreatic disease, were examined. The vitamin D level in blood serum was determined. The results were evaluated according to the age distribution of subjects with pancreatic disease and according to gender. Patients with low vitamin D levels were treated for 24 weeks with a dose of 1.500.000 IU of vitamin D3 per day, and then blood serum vitamin D levels were determined. RESULTS: In people with chronic pancreatitis, vitamin D levels were statistically significantly reduced compared to the control group. There was no statistically significant relationship of vitamin D with gender and age. Supplementation with vitamin D3 achieved an adjustment of vitamin D level to the level of the control group. CONCLUSION: Blood serum vitamin D levels are significantly reduced in people with chronic pancreatitis. Its correction by oral vitamin D supplementation was effective. Whether this adjustment of levels will be effective also in terms of e.g. beneficial effect on fibrogenesis will require further representative studies, because the limitation of the interpretation of the results of our study is the smaller number of subjects with chronic pancreatitis (Tab. 4, Ref. 29). . Text in PDF www.elis.sk

Citovat

PŘECECHTĚLOVÁ, Marie; Petr DÍTĚ; Dana BUČKOVÁ; Martina BOJKOVA; Bohuslav KIANIČKA; David SOLIL a Jiří DOLINA. Vitamin D in blood serum and chronic pancreatitis. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2024, roč. 125, č. 8, s. 508-512. ISSN 0006-9248. Dostupné z: https://doi.org/10.4149/BLL_2024_79.

@article{2455423,
   author = {Přecechtělová, Marie and Dítě, Petr and Bučková, Dana and Bojkova, Martina and Kianička, Bohuslav and Solil, David and Dolina, Jiří},
   article_location = {BRATISLAVA},
   article_number = {8},
   doi = {https://doi.org/10.4149/BLL_2024_79},
   keywords = {chronic pancreatitis; exocrine pancreatic insufficiency; pancreatic fibrosis; vitamin D; vitamin D supplementation},
   language = {eng},
   issn = {0006-9248},
   journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
   title = {Vitamin D in blood serum and chronic pancreatitis},
   url = {https://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8344&category_id=194&option=com_virtuemart&vmcchk=1&Itemid=1},
   volume = {125},
   year = {2024}
}

TY  - JOUR
ID  - 2455423
AU  - Přecechtělová, Marie - Dítě, Petr - Bučková, Dana - Bojkova, Martina - Kianička, Bohuslav - Solil, David - Dolina, Jiří
PY  - 2024
TI  - Vitamin D in blood serum and chronic pancreatitis
JF  - Bratislava Medical Journal - Bratislavské lekárske listy
VL  - 125
IS  - 8
SP  - 508-512
EP  - 508-512
PB  - Univerzita Komenského
SN  - 00069248
KW  - chronic pancreatitis
KW  - exocrine pancreatic insufficiency
KW  - pancreatic fibrosis
KW  - vitamin D
KW  - vitamin D supplementation
UR  - https://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8344&category_id=194&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - Patients with chronic pancreatitis are at risk of developing malabsorption and malnutrition. Exocrine pancreatic insufficiency is accompanied by decreased serum micronutrient levels and low vitamin D levels are a frequent finding in up to 60-80% of patients. The aim of our prospective study was to investigate vitamin D in the blood serum of subjects with chronic pancreatitis with the possibility of influencing the reduced vitamin D levels with supplementation therapy. MATERIAL AND METHODOLOGY: Fifty patients with chronic pancreatitis and 20 subjects in the control group without gastrointestinal tract diseases, including pancreatic disease, were examined. The vitamin D level in blood serum was determined. The results were evaluated according to the age distribution of subjects with pancreatic disease and according to gender. Patients with low vitamin D levels were treated for 24 weeks with a dose of 1.500.000 IU of vitamin D3 per day, and then blood serum vitamin D levels were determined. RESULTS: In people with chronic pancreatitis, vitamin D levels were statistically significantly reduced compared to the control group. There was no statistically significant relationship of vitamin D with gender and age. Supplementation with vitamin D3 achieved an adjustment of vitamin D level to the level of the control group. CONCLUSION: Blood serum vitamin D levels are significantly reduced in people with chronic pancreatitis. Its correction by oral vitamin D supplementation was effective. Whether this adjustment of levels will be effective also in terms of e.g. beneficial effect on fibrogenesis will require further representative studies, because the limitation of the interpretation of the results of our study is the smaller number of subjects with chronic pancreatitis (Tab. 4, Ref. 29). . Text in PDF www.elis.sk
ER  -

PŘECECHTĚLOVÁ, Marie; Petr DÍTĚ; Dana BUČKOVÁ; Martina BOJKOVA; Bohuslav KIANIČKA; David SOLIL a Jiří DOLINA. Vitamin D in blood serum and chronic pancreatitis. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2024, roč.~125, č.~8, s.~508-512. ISSN~0006-9248. Dostupné z: https://doi.org/10.4149/BLL\_{}2024\_{}79.

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