Porous titanium/hydroxyapatite interpenetrating phase
composites with optimal mechanical and biological properties
for personalized bone repair

J 2025

Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair

OLIVER-URRUTIA, Carolina; Adelia KASHIMBETOVA; Karel SLAMECKA; Mariano CASAS-LUNA; Jan MATULA et al.

Základní údaje

Originální název

Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair

Autoři

OLIVER-URRUTIA, Carolina; Adelia KASHIMBETOVA; Karel SLAMECKA; Mariano CASAS-LUNA; Jan MATULA; Zuzana SUMBALOVÁ KOLEDOVÁ; Jozef KAISER; Ladislav CELKO a Edgar B MONTUFAR

Vydání

Biomaterials Advances, AMSTERDAM, Elsevier B.V. 2025, 2772-9508

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20903 Bioproducts biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.000 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140393

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Titanium; Hydroxyapatite; Infiltration; Self-hardening; Ceramic matrix composite; Bone repair

Štítky

14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 11. 2024 10:45, Mgr. Tereza Miškechová

Anotace

V originále

This study introduces the first fabrication of porous titanium/hydroxyapatite interpenetrating phase composites through an innovative processing method. The approach combines additive manufacturing of a customized titanium skeleton with the infiltration of an injectable hydroxyapatite foam, followed by in situ foam hardening at physiological temperature. This biomimetic process circumvents ceramic sintering and metal casting, effectively avoiding the formation of secondary phases that can impair mechanical performance. Hydroxyapatite foams, prepared using two foaming agents (polysorbate 80 and gelatine), significantly reinforce the titanium skeleton while preserving the microstructural characteristics essential for osteoinductive properties. The strengthening mechanisms rely on the conformation of the foams to the titanium surface, thereby enabling stable mechanical interlocking and effective interfacial stress transfer. This, combined with the mechanical constriction of phases, enhances damage tolerance and mechanical reliability of the interpenetrating phase composites. In addition, the interpenetrating phase composites feature a network of concave pores with an optimal size for bone repair, support human osteoblast proliferation, and exhibit mechanical properties compatible with bone, offering a promising solution for the efficient and personalized reconstruction of large bone defects. The results demonstrate a significant advancement in composite fabrication, integrating the benefits of additive manufacturing for bone repair with the osteogenic capacity of calcium phosphate ceramics.

Návaznosti

90251, velká výzkumná infrastruktura

Název: CzechNanoLab II

Citovat

OLIVER-URRUTIA, Carolina; Adelia KASHIMBETOVA; Karel SLAMECKA; Mariano CASAS-LUNA; Jan MATULA; Zuzana SUMBALOVÁ KOLEDOVÁ; Jozef KAISER; Ladislav CELKO a Edgar B MONTUFAR. Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair. Biomaterials Advances. AMSTERDAM: Elsevier B.V., 2025, roč. 166, January 2025, s. 1-11. ISSN 2772-9508. Dostupné z: https://doi.org/10.1016/j.bioadv.2024.214079.

@article{2455466,
   author = {OliverandUrrutia, Carolina and Kashimbetova, Adelia and Slamecka, Karel and CasasandLuna, Mariano and Matula, Jan and Sumbalová Koledová, Zuzana and Kaiser, Jozef and Celko, Ladislav and Montufar, Edgar B},
   article_location = {AMSTERDAM},
   article_number = {January 2025},
   doi = {https://doi.org/10.1016/j.bioadv.2024.214079},
   keywords = {Titanium; Hydroxyapatite; Infiltration; Self-hardening; Ceramic matrix composite; Bone repair},
   language = {eng},
   issn = {2772-9508},
   journal = {Biomaterials Advances},
   title = {Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair},
   url = {https://www.sciencedirect.com/science/article/pii/S2772950824003224?via%3Dihub},
   volume = {166},
   year = {2025}
}

TY  - JOUR
ID  - 2455466
AU  - Oliver-Urrutia, Carolina - Kashimbetova, Adelia - Slamecka, Karel - Casas-Luna, Mariano - Matula, Jan - Sumbalová Koledová, Zuzana - Kaiser, Jozef - Celko, Ladislav - Montufar, Edgar B
PY  - 2025
TI  - Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair
JF  - Biomaterials Advances
VL  - 166
IS  - January 2025
SP  - 1-11
EP  - 1-11
PB  - Elsevier B.V.
SN  - 27729508
KW  - Titanium
KW  - Hydroxyapatite
KW  - Infiltration
KW  - Self-hardening
KW  - Ceramic matrix composite
KW  - Bone repair
UR  - https://www.sciencedirect.com/science/article/pii/S2772950824003224?via%3Dihub
N2  - This study introduces the first fabrication of porous titanium/hydroxyapatite interpenetrating phase composites through an innovative processing method. The approach combines additive manufacturing of a customized titanium skeleton with the infiltration of an injectable hydroxyapatite foam, followed by in situ foam hardening at physiological temperature. This biomimetic process circumvents ceramic sintering and metal casting, effectively avoiding the formation of secondary phases that can impair mechanical performance. Hydroxyapatite foams, prepared using two foaming agents (polysorbate 80 and gelatine), significantly reinforce the titanium skeleton while preserving the microstructural characteristics essential for osteoinductive properties. The strengthening mechanisms rely on the conformation of the foams to the titanium surface, thereby enabling stable mechanical interlocking and effective interfacial stress transfer. This, combined with the mechanical constriction of phases, enhances damage tolerance and mechanical reliability of the interpenetrating phase composites. In addition, the interpenetrating phase composites feature a network of concave pores with an optimal size for bone repair, support human osteoblast proliferation, and exhibit mechanical properties compatible with bone, offering a promising solution for the efficient and personalized reconstruction of large bone defects. The results demonstrate a significant advancement in composite fabrication, integrating the benefits of additive manufacturing for bone repair with the osteogenic capacity of calcium phosphate ceramics.
ER  -

OLIVER-URRUTIA, Carolina; Adelia KASHIMBETOVA; Karel SLAMECKA; Mariano CASAS-LUNA; Jan MATULA; Zuzana SUMBALOVÁ KOLEDOVÁ; Jozef KAISER; Ladislav CELKO a Edgar B MONTUFAR. Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair. \textit{Biomaterials Advances}. AMSTERDAM: Elsevier B.V., 2025, roč.~166, January 2025, s.~1-11. ISSN~2772-9508. Dostupné z: https://doi.org/10.1016/j.bioadv.2024.214079.

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