Neural Implications of Post-COVID-19 Condition: Preliminary
Insights

a 2023

Neural Implications of Post-COVID-19 Condition: Preliminary Insights

BARTEČKOVÁ, Eliška; Pavel FILIP; Lubomír VOJTÍŠEK; Jana HOŘÍNKOVÁ; Martin RADVAN et al.

Základní údaje

Originální název

Neural Implications of Post-COVID-19 Condition: Preliminary Insights

Autoři

BARTEČKOVÁ, Eliška; Pavel FILIP; Lubomír VOJTÍŠEK; Jana HOŘÍNKOVÁ a Martin RADVAN

Vydání

Imaging Principles of Life, October 3-4 2023 EA Hotel Tereziánský dvůr Hradec Králové, 2023

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30210 Clinical neurology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/23:00137812

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Post-COVID-19 Condition; Neural Implications

Změněno: 28. 11. 2024 13:31, Mgr. Tereza Miškechová

Anotace

V originále

Background: Post-SARS-CoV-2 infection, many patients exhibit persistent symptoms termed the post- COVID-19 condition, encompassing fatigue, cognitive dysfunction, and neuropsychiatric issues. The potential link between this condition and increased risk of psychiatric or neurodegenerative disorders post-infection has raised concerns. Neuroimaging is viewed as a key tool for understanding this condition's biological foundation. Aim and Objectives: The study aimed to explore COVID-19's impact on neural plasticity and brain function. Objectives included identifying neuroanatomical signatures using MR imaging, EEG, and cognitive parameters; charting the condition's progression; and assessing acute COVID-19 or its treatment's influence on the condition's manifestation. Methods: A longitudinal study was conducted on post SARS-CoV-2 patients, categorized based on post-COVID-19 symptoms. Evaluations occurred at baseline, 12, and 24 months, involving MRI, EEG, and blood tests. Preliminary Results: Based on the initial timepoint, several patterns were observed among the 67 post-COVID-19 and 52 recovery subjects. An elevation in T2 and T2rho relaxation times was noted in post- COVID-19 subjects within the prefrontal and mesiotemporal areas, suggesting potential iron involvement. A reduction in T1rho relaxation times in these regions was also observed. These neural patterns bear similarities to processes typically seen during aging. However, results from subcortical regions, particularly the hippocampus and cerebellum, were inconsistent. Limitations: The findings are preliminary and require a broader analysis, including rsfMRI and DWI, for comprehensive understanding. Conclusion: Early findings suggest neural ramifications of the post-COVID-19 condition, drawing parallels with aging. Further research is anticipated for a deeper understanding.

Návaznosti

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

Citovat

BARTEČKOVÁ, Eliška; Pavel FILIP; Lubomír VOJTÍŠEK; Jana HOŘÍNKOVÁ a Martin RADVAN. Neural Implications of Post-COVID-19 Condition: Preliminary Insights. In Imaging Principles of Life, October 3-4 2023 EA Hotel Tereziánský dvůr Hradec Králové. 2023.

@proceedings{2455542,
   author = {Bartečková, Eliška and Filip, Pavel and Vojtíšek, Lubomír and Hořínková, Jana and Radvan, Martin},
   booktitle = {Imaging Principles of Life, October 3-4 2023 EA Hotel Tereziánský dvůr Hradec Králové},
   keywords = {Post-COVID-19 Condition; Neural Implications},
   language = {eng},
   title = {Neural Implications of Post-COVID-19 Condition: Preliminary Insights},
   year = {2023}
}

TY  - CONF
ID  - 2455542
AU  - Bartečková, Eliška - Filip, Pavel - Vojtíšek, Lubomír - Hořínková, Jana - Radvan, Martin
PY  - 2023
TI  - Neural Implications of Post-COVID-19 Condition: Preliminary Insights
KW  - Post-COVID-19 Condition
KW  - Neural Implications
N2  - Background: Post-SARS-CoV-2 infection, many patients exhibit persistent symptoms termed the post- COVID-19 condition, encompassing fatigue, cognitive dysfunction, and neuropsychiatric issues. The potential link between this condition and increased risk of psychiatric or neurodegenerative disorders post-infection has raised concerns. Neuroimaging is viewed as a key tool for understanding this condition's biological foundation. Aim and Objectives: The study aimed to explore COVID-19's impact on neural plasticity and brain function. Objectives included identifying neuroanatomical signatures using MR imaging, EEG, and cognitive parameters; charting the condition's progression; and assessing acute COVID-19 or its treatment's influence on the condition's manifestation. Methods: A longitudinal study was conducted on post SARS-CoV-2 patients, categorized based on post-COVID-19 symptoms. Evaluations occurred at baseline, 12, and 24 months, involving MRI, EEG, and blood tests. Preliminary Results: Based on the initial timepoint, several patterns were observed among the 67 post-COVID-19 and 52 recovery subjects. An elevation in T2 and T2rho relaxation times was noted in post- COVID-19 subjects within the prefrontal and mesiotemporal areas, suggesting potential iron involvement. A reduction in T1rho relaxation times in these regions was also observed. These neural patterns bear similarities to processes typically seen during aging. However, results from subcortical regions, particularly the hippocampus and cerebellum, were inconsistent. Limitations: The findings are preliminary and require a broader analysis, including rsfMRI and DWI, for comprehensive understanding. Conclusion: Early findings suggest neural ramifications of the post-COVID-19 condition, drawing parallels with aging. Further research is anticipated for a deeper understanding.
ER  -

BARTEČKOVÁ, Eliška; Pavel FILIP; Lubomír VOJTÍŠEK; Jana HOŘÍNKOVÁ a Martin RADVAN. Neural Implications of Post-COVID-19 Condition: Preliminary Insights. In \textit{Imaging Principles of Life, October 3-4 2023 EA Hotel Tereziánský dvůr Hradec Králové}. 2023.

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