Early Changes in the Locus Coeruleus in Mild Cognitive
Impairment with Lewy Bodies

J 2025

Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies

ŽELEZNÍKOVÁ, Žaneta; Ľubomíra NOVÁKOVÁ; Lubomír VOJTÍŠEK; Luboš BRABENEC; Kristína MITTEROVÁ et. al.

Základní údaje

Originální název

Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies

Autoři

ŽELEZNÍKOVÁ, Žaneta (703 Slovensko, domácí); Ľubomíra NOVÁKOVÁ (703 Slovensko, domácí); Lubomír VOJTÍŠEK (203 Česká republika, domácí); Luboš BRABENEC (203 Česká republika, domácí); Kristína MITTEROVÁ (703 Slovensko, domácí); Ivona MORÁVKOVÁ (703 Slovensko, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Movement Disorders, Hoboken, Wiley, 2025, 0885-3185

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.400 v roce 2023

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/mds.30058

UT WoS

001358093800001

EID Scopus

2-s2.0-85208931094

Klíčová slova anglicky

mild cognitive impairment with Lewy bodies; neuromelanin-sensitive magnetic resonance imaging; locus coeruleus

Štítky

14110127, 14110132, CF MAFIL, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 5. 2025 12:49, Mgr. Eva Dubská

Anotace

V originále

Background: Although neuromelanin-sensitive magnetic resonance imaging (NM-MRI) has been used to evaluate early neurodegeneration in Parkinson's disease, studies concentrating on the locus coeruleus (LC) in pre-dementia stages of dementia with Lewy bodies (DLB) are lacking. Objectives: The aims were to evaluate NM-MRI signal changes in the LC in patients with mild cognitive impairment with Lewy bodies (MCI-LB) compared to healthy controls (HC) and to identify the cognitive correlates of the changes. We also aimed to test the hypothesis of a caudal-rostral alpha-synuclein pathology spread using NM-MRI of the different LC subparts. Methods: A total of 38 MCI-LB patients and 59 HCs underwent clinical and cognitive testing and NM-MRI of the LC. We calculated the contrast ratio of NM-MRI signal (LC-CR) in the whole LC as well as in its caudal, middle, and rostral MRI slices, and we compared the LC-CR values between the MCI-LB and HC groups. Linear regression analyses were performed to assess the relationship between the LC-CR and cognitive outcomes. Results: The MCI-LB group exhibited a significant reduction in the right LC-CR compared to HCs (P = 0.021). The right LC-CR decrease was associated with impaired visuospatial memory in the MCI-LB group. Only the caudal part of the LC exhibited significant LC-CR decreases in MCI-LB patients compared to HCs on both sides (P < 0.0001). Conclusions: This is the first study that focuses on LC-CRs in MCI-LB patients and analyzes the LC subparts, offering new insights into the LC integrity alterations in the initial stages of DLB and their clinical correlates. (c) 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Návaznosti

LX22NPO5107, projekt VaV

Název: Národní ústav pro neurologický výzkum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro neurologický výzkum, 5.1 EXCELES

NU23J-04-00005, projekt VaV

Název: Jazyk a onemocnění s Lewyho tělísky: Problémy s porozuměním větám a modifikující terapie pomocí neinvazivní stimulace mozku

Investor: Ministerstvo zdravotnictví ČR, Jazyk a onemocnění s Lewyho tělísky: Problémy s porozuměním větám a modifikující terapie pomocí neinvazivní stimulace mozku

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

90250, velká výzkumná infrastruktura

Název: Czech-BioImaging III

Citovat

ŽELEZNÍKOVÁ, Žaneta; Ľubomíra NOVÁKOVÁ; Lubomír VOJTÍŠEK; Luboš BRABENEC; Kristína MITTEROVÁ; Ivona MORÁVKOVÁ a Irena REKTOROVÁ. Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies. Movement Disorders. Hoboken: Wiley, 2025, roč. 2024, Nov, s. 1-10. ISSN 0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.30058.

@article{2456601,
   author = {Železníková, Žaneta and Nováková, Ľubomíra and Vojtíšek, Lubomír and Brabenec, Luboš and Mitterová, Kristína and Morávková, Ivona and Rektorová, Irena},
   article_location = {Hoboken},
   article_number = {Nov},
   doi = {http://dx.doi.org/10.1002/mds.30058},
   keywords = {mild cognitive impairment with Lewy bodies; neuromelanin-sensitive magnetic resonance imaging; locus coeruleus},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies},
   url = {https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.30058},
   volume = {2024},
   year = {2025}
}

TY  - JOUR
ID  - 2456601
AU  - Železníková, Žaneta - Nováková, Ľubomíra - Vojtíšek, Lubomír - Brabenec, Luboš - Mitterová, Kristína - Morávková, Ivona - Rektorová, Irena
PY  - 2025
TI  - Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies
JF  - Movement Disorders
VL  - 2024
IS  - Nov
SP  - 1-10
EP  - 1-10
PB  - Wiley
SN  - 08853185
KW  - mild cognitive impairment with Lewy bodies
KW  - neuromelanin-sensitive magnetic resonance imaging
KW  - locus coeruleus
UR  - https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.30058
N2  - Background: Although neuromelanin-sensitive magnetic resonance imaging (NM-MRI) has been used to evaluate early neurodegeneration in Parkinson's disease, studies concentrating on the locus coeruleus (LC) in pre-dementia stages of dementia with Lewy bodies (DLB) are lacking. Objectives: The aims were to evaluate NM-MRI signal changes in the LC in patients with mild cognitive impairment with Lewy bodies (MCI-LB) compared to healthy controls (HC) and to identify the cognitive correlates of the changes. We also aimed to test the hypothesis of a caudal-rostral alpha-synuclein pathology spread using NM-MRI of the different LC subparts. Methods: A total of 38 MCI-LB patients and 59 HCs underwent clinical and cognitive testing and NM-MRI of the LC. We calculated the contrast ratio of NM-MRI signal (LC-CR) in the whole LC as well as in its caudal, middle, and rostral MRI slices, and we compared the LC-CR values between the MCI-LB and HC groups. Linear regression analyses were performed to assess the relationship between the LC-CR and cognitive outcomes. Results: The MCI-LB group exhibited a significant reduction in the right LC-CR compared to HCs (P = 0.021). The right LC-CR decrease was associated with impaired visuospatial memory in the MCI-LB group. Only the caudal part of the LC exhibited significant LC-CR decreases in MCI-LB patients compared to HCs on both sides (P < 0.0001). Conclusions: This is the first study that focuses on LC-CRs in MCI-LB patients and analyzes the LC subparts, offering new insights into the LC integrity alterations in the initial stages of DLB and their clinical correlates. (c) 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
ER  -

ŽELEZNÍKOVÁ, Žaneta; Ľubomíra NOVÁKOVÁ; Lubomír VOJTÍŠEK; Luboš BRABENEC; Kristína MITTEROVÁ; Ivona MORÁVKOVÁ a Irena REKTOROVÁ. Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies. \textit{Movement Disorders}. Hoboken: Wiley, 2025, roč.~2024, Nov, s.~1-10. ISSN~0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.30058.

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