Tumor Suppressor miR-34a: Potential Biomarker of TACE Response
in HCC

J 2025

Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC

ZAVADIL, Jan; Jaroslav JURÁČEK; Barbora ČECHOVÁ; Tomáš ROHAN; Jakub HUSTÝ et al.

Základní údaje

Originální název

Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC

Název česky

Tumor supresor miR-34a: Potenciální biomarker ke zhodnocení léčby u HCC pomocí TACE

Autoři

ZAVADIL, Jan; Jaroslav JURÁČEK; Barbora ČECHOVÁ; Tomáš ROHAN; Jakub HUSTÝ; Ondřej SLABÝ; Martina LITSCHMANNOVÁ; Michal UHER; S. Nahum GOLDBERG a Tomáš ANDRAŠINA

Vydání

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, NEW YORK, Springer Nature, 2025, 0174-1551

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140408

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

Degradabilní a nedegradabilní částice; Hepatocelulární karcinom, Hypoxie; MikroRNA a Vaskulární endoteliální růstový faktor; Transarteriální chemoembolizace; Tumor supresor

Klíčová slova anglicky

Degradable and nondegradable particles; Hepatocellular carcinoma; Hypoxia; MicroRNA and vascular endothelial growth factor; Transarterial chemoembolization; Tumor suppressor.

Štítky

14110216

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2026 09:14, Mgr. Tereza Miškechová

Anotace

V originále

Purpose TACE induces variable systemic effects by producing factors that promote inflammation, oncogenesis, and angiogenesis. Here we compare concentrations of microRNAs (miR-21, miR-210 and miR-34a) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) patients undergoing TACE with degradable (DSM) and nondegradable (DEB) particles and potential use of these biomarker changes for prediction of patient outcomes. Materials and Methods Overall, 52 patients with HCC treated with DSM TACE (24 patients) and DEB TACE (28 patients) were included in this prospective study. Concentrations of studied biomarkers were measured from blood plasma preprocedurally, immediately (< 90 min) postprocedurally, and 24-h after TACE. Levels were compared between DSM and DEB TACE and correlated with treatment response six and 12 months after the first TACE. Results Both DSM and DEB TACE elevated plasma levels of miR-21, miR-34a, and miR-210 at 24 h post-procedure compared to baseline levels (FC 1.25–4.0). MiR-34a elevation immediately after TACE was significantly associated with nonprogressive disease compared to those with progressive disease at both six months (FCa: p = 0.014) and 12 months (FCa: p = 0.029) post-TACE. No significant biomarker changes were found between the embolization particle groups. However, VEGF levels showed a decrease only in the DSM TACE group (FC24: p = < 0.001). Conclusion Embolization particle type did not significantly impact miRNA or VEGF changes post-TACE. However, miR-34a elevation immediately after the procedure predicts better patient outcome and may prove useful as a biomarkers for the monitoring of clinical outcomes.

Návaznosti

MUNI/A/1611/2023, interní kód MU

Název: Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

Investor: Masarykova univerzita, Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

NV16-31314A, projekt VaV

Název: Identifikace cirkulujících mikroRNA umožňujících prognostickou stratifikaci a selekci pacientů nejvíce profitujících z chirurgické léčby

NV16-31765A, projekt VaV

Název: Využití tkáňových/cirkulujících mikroRNA pro predikci léčebné odpovědi a zpřesnění restagingu karcinomu rekta po neoadjuvantní léčbě

90233, velká výzkumná infrastruktura

Název: BBMRI.cz IV

Citovat

ZAVADIL, Jan; Jaroslav JURÁČEK; Barbora ČECHOVÁ; Tomáš ROHAN; Jakub HUSTÝ; Ondřej SLABÝ; Martina LITSCHMANNOVÁ; Michal UHER; S. Nahum GOLDBERG a Tomáš ANDRAŠINA. Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC. CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. NEW YORK: Springer Nature, 2025, roč. 48, č. 1, s. 26-37. ISSN 0174-1551. Dostupné z: https://doi.org/10.1007/s00270-024-03908-5.

@article{2458117,
   author = {Zavadil, Jan and Juráček, Jaroslav and Čechová, Barbora and Rohan, Tomáš and Hustý, Jakub and Slabý, Ondřej and Litschmannová, Martina and Uher, Michal and Goldberg, S. Nahum and Andrašina, Tomáš},
   article_location = {NEW YORK},
   article_number = {1},
   doi = {https://doi.org/10.1007/s00270-024-03908-5},
   keywords = {Degradable and nondegradable particles; Hepatocellular carcinoma; Hypoxia; MicroRNA and vascular endothelial growth factor; Transarterial chemoembolization; Tumor suppressor.},
   language = {eng},
   issn = {0174-1551},
   journal = {CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY},
   title = {Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC},
   url = {https://link.springer.com/article/10.1007/s00270-024-03908-5},
   volume = {48},
   year = {2025}
}

TY  - JOUR
ID  - 2458117
AU  - Zavadil, Jan - Juráček, Jaroslav - Čechová, Barbora - Rohan, Tomáš - Hustý, Jakub - Slabý, Ondřej - Litschmannová, Martina - Uher, Michal - Goldberg, S. Nahum - Andrašina, Tomáš
PY  - 2025
TI  - Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC
JF  - CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
VL  - 48
IS  - 1
SP  - 26-37
EP  - 26-37
PB  - Springer Nature
SN  - 01741551
KW  - Degradable and nondegradable particles
KW  - Hepatocellular carcinoma
KW  - Hypoxia
KW  - MicroRNA and vascular endothelial growth factor
KW  - Transarterial chemoembolization
KW  - Tumor suppressor.
UR  - https://link.springer.com/article/10.1007/s00270-024-03908-5
N2  - Purpose TACE induces variable systemic effects by producing factors that promote inflammation, oncogenesis, and angiogenesis. Here we compare concentrations of microRNAs (miR-21, miR-210 and miR-34a) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) patients undergoing TACE with degradable (DSM) and nondegradable (DEB) particles and potential use of these biomarker changes for prediction of patient outcomes. Materials and Methods Overall, 52 patients with HCC treated with DSM TACE (24 patients) and DEB TACE (28 patients) were included in this prospective study. Concentrations of studied biomarkers were measured from blood plasma preprocedurally, immediately (< 90 min) postprocedurally, and 24-h after TACE. Levels were compared between DSM and DEB TACE and correlated with treatment response six and 12 months after the first TACE. Results Both DSM and DEB TACE elevated plasma levels of miR-21, miR-34a, and miR-210 at 24 h post-procedure compared to baseline levels (FC 1.25–4.0). MiR-34a elevation immediately after TACE was significantly associated with nonprogressive disease compared to those with progressive disease at both six months (FCa: p = 0.014) and 12 months (FCa: p = 0.029) post-TACE. No significant biomarker changes were found between the embolization particle groups. However, VEGF levels showed a decrease only in the DSM TACE group (FC24: p = < 0.001). Conclusion Embolization particle type did not significantly impact miRNA or VEGF changes post-TACE. However, miR-34a elevation immediately after the procedure predicts better patient outcome and may prove useful as a biomarkers for the monitoring of clinical outcomes.
ER  -

ZAVADIL, Jan; Jaroslav JURÁČEK; Barbora ČECHOVÁ; Tomáš ROHAN; Jakub HUSTÝ; Ondřej SLABÝ; Martina LITSCHMANNOVÁ; Michal UHER; S. Nahum GOLDBERG a Tomáš ANDRAŠINA. Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC. \textit{CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY}. NEW YORK: Springer Nature, 2025, roč.~48, č.~1, s.~26-37. ISSN~0174-1551. Dostupné z: https://doi.org/10.1007/s00270-024-03908-5.

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