Present Mind in the Ageing Brain: Neural Associations of
Dispositional Mindfulness in Cognitive Decline

J 2025

Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline

ŠUMEC, Rastislav; Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA; Dusana DORJEE et. al.

Základní údaje

Originální název

Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline

Autoři

ŠUMEC, Rastislav; Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA; Dusana DORJEE; Jakub HORT a Kateřina SHEARDOVÁ

Vydání

Mindfulness, Springer, 2025, 1868-8527

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

50101 Psychology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.500 v roce 2024

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1007/s12671-024-02500-9

UT WoS

001386860400001

EID Scopus

2-s2.0-85213807750

Klíčová slova anglicky

Mindfulness; Default mode network; Cognition; Subjective cognitive decline; Mild cognitive impairment

Štítky

14110127, 14110523, 14311010, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 3. 2025 08:32, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Objective: Patients at risk of dementia, such as those with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), present with specific clinical symptoms, as well as functional and structural changes within the brain. Dispositional mindfulness (DM) has been linked to better cognition and is associated with activation and grey matter volume changes in specific brain regions in healthy adults. This study aimed to investigate how DM changes along the trajectory of cognitive decline in patients at risk for AD and to identify the brain structures that may be responsible for these changes in DM. Method: In total, 79 older adults (SCD = 48, MCI = 31) underwent cognitive testing and brain MRI volumetry, resting-state functional MRI derived connectivity, and diffusion-weighted imaging. DM was assessed with the Breath Counting Task (BCT). Results: Participants with MCI showed worse mean counting accuracy in the BCT compared to those with SCD (adjusted p < 0.001). Higher functional connectivity of the ventromedial prefrontal cortex predicted greater counting accuracy in MCI, but not in SCD. The difference between MCI and SCD in regression slope was also statistically significant for ventromedial prefrontal cortex functional connectivity (adjusted p = 0.002). No other statistically significant associations were found between DM, MRI indices, and neuropsychological variables in either group. Conclusion: MCI and SCD were associated with distinctly different levels of DM, possibly due to more severe cognitive decline in MCI. Functional changes in ventromedial prefrontal cortex in MCI could play a key role in the worsening of DM in this population. Preregistration: This study is not preregistered.

Návaznosti

MUNI/A/1342/2021, interní kód MU

Název: Matematické a statistické modelování 6 (Akronym: MaStaMo6)

Investor: Masarykova univerzita, Matematické a statistické modelování 6

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

Citovat

ŠUMEC, Rastislav; Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA; Dusana DORJEE; Jakub HORT a Kateřina SHEARDOVÁ. Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline. Mindfulness. Springer, 2025, roč. 16, č. 1, s. 76-90. ISSN 1868-8527. Dostupné z: https://doi.org/10.1007/s12671-024-02500-9.

@article{2465060,
   author = {Šumec, Rastislav and Filip, Pavel and Vyhnálek, Martin and Katina, Stanislav and Dorjee, Dusana and Hort, Jakub and Sheardová, Kateřina},
   article_number = {1},
   doi = {https://doi.org/10.1007/s12671-024-02500-9},
   keywords = {Mindfulness; Default mode network; Cognition; Subjective cognitive decline; Mild cognitive impairment},
   language = {eng},
   issn = {1868-8527},
   journal = {Mindfulness},
   title = {Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline},
   url = {https://link.springer.com/article/10.1007/s12671-024-02500-9},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 2465060
AU  - Šumec, Rastislav - Filip, Pavel - Vyhnálek, Martin - Katina, Stanislav - Dorjee, Dusana - Hort, Jakub - Sheardová, Kateřina
PY  - 2025
TI  - Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline
JF  - Mindfulness
VL  - 16
IS  - 1
SP  - 76-90
EP  - 76-90
PB  - Springer
SN  - 18688527
KW  - Mindfulness
KW  - Default mode network
KW  - Cognition
KW  - Subjective cognitive decline
KW  - Mild cognitive impairment
UR  - https://link.springer.com/article/10.1007/s12671-024-02500-9
N2  - Objective: Patients at risk of dementia, such as those with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), present with specific clinical symptoms, as well as functional and structural changes within the brain. Dispositional mindfulness (DM) has been linked to better cognition and is associated with activation and grey matter volume changes in specific brain regions in healthy adults. This study aimed to investigate how DM changes along the trajectory of cognitive decline in patients at risk for AD and to identify the brain structures that may be responsible for these changes in DM. Method: In total, 79 older adults (SCD = 48, MCI = 31) underwent cognitive testing and brain MRI volumetry, resting-state functional MRI derived connectivity, and diffusion-weighted imaging. DM was assessed with the Breath Counting Task (BCT). Results: Participants with MCI showed worse mean counting accuracy in the BCT compared to those with SCD (adjusted p < 0.001). Higher functional connectivity of the ventromedial prefrontal cortex predicted greater counting accuracy in MCI, but not in SCD. The difference between MCI and SCD in regression slope was also statistically significant for ventromedial prefrontal cortex functional connectivity (adjusted p = 0.002). No other statistically significant associations were found between DM, MRI indices, and neuropsychological variables in either group. Conclusion: MCI and SCD were associated with distinctly different levels of DM, possibly due to more severe cognitive decline in MCI. Functional changes in ventromedial prefrontal cortex in MCI could play a key role in the worsening of DM in this population. Preregistration: This study is not preregistered.
ER  -

ŠUMEC, Rastislav; Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA; Dusana DORJEE; Jakub HORT a Kateřina SHEARDOVÁ. Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline. \textit{Mindfulness}. Springer, 2025, roč.~16, č.~1, s.~76-90. ISSN~1868-8527. Dostupné z: https://doi.org/10.1007/s12671-024-02500-9.

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