Primary cilia-associated signalling in squamous cell carcinoma
of head and neck region

J 2024

Primary cilia-associated signalling in squamous cell carcinoma of head and neck region

PUTNOVÁ, Iveta; Barbora MOLDOVAN PUTNOVÁ; Pavel HURNÍK; Jan ŠTEMBÍREK; Marcela BUCHTOVÁ et al.

Základní údaje

Originální název

Primary cilia-associated signalling in squamous cell carcinoma of head and neck region

Autoři

PUTNOVÁ, Iveta; Barbora MOLDOVAN PUTNOVÁ; Pavel HURNÍK; Jan ŠTEMBÍREK; Marcela BUCHTOVÁ a Petra KOLÍSKOVÁ

Vydání

Frontiers in Oncology, Frontiers Media SA, 2024, 2234-943X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.300

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00138372

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

head and neck cancer; primary cilium; Hedgehog; Wnt; PDGF; oral squamous cell carcinoma; signalling pathway inhibitors

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 1. 2025 12:39, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area.

Návaznosti

MUNI/R/1389/2023, interní kód MU

Název: Úloha primárních cilií v rozvoji spinocelulárního karcinomu dutiny ústní

Investor: Masarykova univerzita, Úloha primárních cilií v rozvoji spinocelulárního karcinomu dutiny ústní, CAREER RESTART

Citovat

PUTNOVÁ, Iveta; Barbora MOLDOVAN PUTNOVÁ; Pavel HURNÍK; Jan ŠTEMBÍREK; Marcela BUCHTOVÁ a Petra KOLÍSKOVÁ. Primary cilia-associated signalling in squamous cell carcinoma of head and neck region. Frontiers in Oncology. Frontiers Media SA, 2024, roč. 14, August, s. 1-20. ISSN 2234-943X. Dostupné z: https://doi.org/10.3389/fonc.2024.1413255.

@article{2466219,
   author = {Putnová, Iveta and Moldovan Putnová, Barbora and Hurník, Pavel and Štembírek, Jan and Buchtová, Marcela and Kolísková, Petra},
   article_number = {August},
   doi = {https://doi.org/10.3389/fonc.2024.1413255},
   keywords = {head and neck cancer; primary cilium; Hedgehog; Wnt; PDGF; oral squamous cell carcinoma; signalling pathway inhibitors},
   language = {eng},
   issn = {2234-943X},
   journal = {Frontiers in Oncology},
   title = {Primary cilia-associated signalling in squamous cell carcinoma of head and neck region},
   url = {https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1413255/full},
   volume = {14},
   year = {2024}
}

TY  - JOUR
ID  - 2466219
AU  - Putnová, Iveta - Moldovan Putnová, Barbora - Hurník, Pavel - Štembírek, Jan - Buchtová, Marcela - Kolísková, Petra
PY  - 2024
TI  - Primary cilia-associated signalling in squamous cell carcinoma of head and neck region
JF  - Frontiers in Oncology
VL  - 14
IS  - August
SP  - 1-20
EP  - 1-20
PB  - Frontiers Media SA
SN  - 2234943X
KW  - head and neck cancer
KW  - primary cilium
KW  - Hedgehog
KW  - Wnt
KW  - PDGF
KW  - oral squamous cell carcinoma
KW  - signalling pathway inhibitors
UR  - https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1413255/full
N2  - Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area.
ER  -

PUTNOVÁ, Iveta; Barbora MOLDOVAN PUTNOVÁ; Pavel HURNÍK; Jan ŠTEMBÍREK; Marcela BUCHTOVÁ a Petra KOLÍSKOVÁ. Primary cilia-associated signalling in squamous cell carcinoma of head and neck region. \textit{Frontiers in Oncology}. Frontiers Media SA, 2024, roč.~14, August, s.~1-20. ISSN~2234-943X. Dostupné z: https://doi.org/10.3389/fonc.2024.1413255.

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