Evaluating the need for standardised disease manifestation
categories in patients infected with the tick-borne
encephalitis virus: A Delphi panel

J 2025

Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel

HALSBY, Kate; Gerhard DOBLER; Ava EASTON; Guntis KARELIS; Lenka KRBKOVÁ et al.

Základní údaje

Originální název

Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel

Autoři

Vydání

Ticks and Tick-borne Diseases, Munich, Elsevier, 2025, 1877-959X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.400 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140492

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Delphi panel; Tick-borne encephalitis; Categorisation; Disease severity

Štítky

14110318, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 2. 2025 09:57, Mgr. Tereza Miškechová

Anotace

V originále

Categorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with diverse expertise in TBEV infection. Consensus was sought using the Delphi technique, which consisted of 2 web-based survey questionnaires and a final, virtual, consensus-building exercise. Ten panellists representing 8 European countries participated in the Delphi exercise, with specialities in neurology, infectious disease, paediatrics, immunology, virology, and epidemiology. Panellists reached unanimous consensus on the need for a standardised, international categorisation system to capture both clinical presentation and severity of TBEV infection. Ideally, such a system should be feasible for use at bedside, be clear and easy to understand, and capture both the acute and follow-up phases of TBEV infection. Areas requiring further discussion were (1) the timepoints at which assessments should be made and (2) whether there should be a separate system for children. This Delphi panel study found that a critical gap persists in the absence of a feasible and practical classification system for TBEV infection. Specifically, the findings of our Delphi exercise highlight the need for the development of a user-friendly classification system that captures the acute and follow-up (i.e., outcome) phases of TBEV infection and optimally reflects both clinical presentation and severity. Development of a clinical categorisation system will enhance patient care and foster comparability among studies, thereby supporting treatment development, refining vaccine strategies, and fortifying public health surveillance.

Citovat

HALSBY, Kate; Gerhard DOBLER; Ava EASTON; Guntis KARELIS; Lenka KRBKOVÁ; Jan KYNCL; Johann SELLNER; Franc STRLE; Malin VEJE; Joanna ZAJKOWSKA; Dace ZAVADSKA; Frederick J ANGULO; Andreas PILZ; Wilhelm ERBER; Meghan GABRIEL; Jon RUSSO; Mark PRICE; Harish MADHAVA a Uta Katharina MEYDING-LAMADÉ. Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel. Ticks and Tick-borne Diseases. Munich: Elsevier, 2025, roč. 16, č. 1, s. 1-10. ISSN 1877-959X. Dostupné z: https://doi.org/10.1016/j.ttbdis.2024.102431.

@article{2466236,
   author = {Halsby, Kate and Dobler, Gerhard and Easton, Ava and Karelis, Guntis and Krbková, Lenka and Kyncl, Jan and Sellner, Johann and Strle, Franc and Veje, Malin and Zajkowska, Joanna and Zavadska, Dace and Angulo, Frederick J and Pilz, Andreas and Erber, Wilhelm and Gabriel, Meghan and Russo, Jon and Price, Mark and Madhava, Harish and MeydingandLamadé, Uta Katharina},
   article_location = {Munich},
   article_number = {1},
   doi = {https://doi.org/10.1016/j.ttbdis.2024.102431},
   keywords = {Delphi panel; Tick-borne encephalitis; Categorisation; Disease severity},
   language = {eng},
   issn = {1877-959X},
   journal = {Ticks and Tick-borne Diseases},
   title = {Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel},
   url = {https://www.sciencedirect.com/science/article/pii/S1877959X24001249},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 2466236
AU  - Halsby, Kate - Dobler, Gerhard - Easton, Ava - Karelis, Guntis - Krbková, Lenka - Kyncl, Jan - Sellner, Johann - Strle, Franc - Veje, Malin - Zajkowska, Joanna - Zavadska, Dace - Angulo, Frederick J - Pilz, Andreas - Erber, Wilhelm - Gabriel, Meghan - Russo, Jon - Price, Mark - Madhava, Harish - Meyding-Lamadé, Uta Katharina
PY  - 2025
TI  - Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel
JF  - Ticks and Tick-borne Diseases
VL  - 16
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - Elsevier
SN  - 1877959X
KW  - Delphi panel
KW  - Tick-borne encephalitis
KW  - Categorisation
KW  - Disease severity
UR  - https://www.sciencedirect.com/science/article/pii/S1877959X24001249
N2  - Categorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with diverse expertise in TBEV infection. Consensus was sought using the Delphi technique, which consisted of 2 web-based survey questionnaires and a final, virtual, consensus-building exercise. Ten panellists representing 8 European countries participated in the Delphi exercise, with specialities in neurology, infectious disease, paediatrics, immunology, virology, and epidemiology. Panellists reached unanimous consensus on the need for a standardised, international categorisation system to capture both clinical presentation and severity of TBEV infection. Ideally, such a system should be feasible for use at bedside, be clear and easy to understand, and capture both the acute and follow-up phases of TBEV infection. Areas requiring further discussion were (1) the timepoints at which assessments should be made and (2) whether there should be a separate system for children. This Delphi panel study found that a critical gap persists in the absence of a feasible and practical classification system for TBEV infection. Specifically, the findings of our Delphi exercise highlight the need for the development of a user-friendly classification system that captures the acute and follow-up (i.e., outcome) phases of TBEV infection and optimally reflects both clinical presentation and severity. Development of a clinical categorisation system will enhance patient care and foster comparability among studies, thereby supporting treatment development, refining vaccine strategies, and fortifying public health surveillance.
ER  -

HALSBY, Kate; Gerhard DOBLER; Ava EASTON; Guntis KARELIS; Lenka KRBKOVÁ; Jan KYNCL; Johann SELLNER; Franc STRLE; Malin VEJE; Joanna ZAJKOWSKA; Dace ZAVADSKA; Frederick J ANGULO; Andreas PILZ; Wilhelm ERBER; Meghan GABRIEL; Jon RUSSO; Mark PRICE; Harish MADHAVA a Uta Katharina MEYDING-LAMADÉ. Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel. \textit{Ticks and Tick-borne Diseases}. Munich: Elsevier, 2025, roč.~16, č.~1, s.~1-10. ISSN~1877-959X. Dostupné z: https://doi.org/10.1016/j.ttbdis.2024.102431.

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