Vancomycin wound penetration in open-heart surgery patients
receiving negative pressure wound therapy for deep sternal
wound infection

J 2025

Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection

KOLEK, Martin; Jana DURICOVA; Hana BROZMANOVA; Pavel SISTIK; Jan JUŘICA et al.

Základní údaje

Originální název

Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection

Autoři

KOLEK, Martin; Jana DURICOVA; Hana BROZMANOVA; Pavel SISTIK; Jan JUŘICA; Klara KANKOVA; Oldrich MOTYKA a Ivana KACIROVA

Vydání

Annals of Medicine, ABINGDON, TAYLOR & FRANCIS LTD, 2025, 0785-3890

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140504

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Deep sternal wound infection; exudate; negative pressure wound therapy; open-heart surgery; vancomycin; wound penetration

Štítky

14110516, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 1. 2025 09:29, Mgr. Tereza Miškechová

Anotace

V originále

IntroductionIt is hypothesized that systemically administered antibiotics penetrate wound sites more effectively during negative pressure wound therapy (NPWT). However, there is a lack of clinical data from patients who receive NPWT for deep sternal wound infection (DSWI) after open-heart surgery. Here, we evaluated vancomycin penetration into exudate in this patient group. Patients and methodsFor this prospective observational study, we enrolled 10 consecutive patients treated with NPWT for post-sternotomy DSWI. On the first sampling day, serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3 and 6 h after vancomycin administration. On the following three consecutive days, additional samples were collected, only before vancomycin administration. ResultsThe ratio of average vancomycin concentration in wound exudate to in serum was higher for free (unbound) (1.51 +/- 0.53) than for total (bound + unbound) (0.91 +/- 0.29) concentration (p = 0.049). The percentage of free vancomycin was higher in wound exudate than serum (0.79 +/- 0.19 vs. 0.46 +/- 0.16; p = 0.04). Good vancomycin wound penetration was maintained on the following three days (vancomycin trough exudate-to-serum concentration ratio > 1). The total hospital stay was significantly longer in patients with DSWI (46 +/- 11.6 days) versus without DSWI (14 +/- 11.7 days) (p < 0.001). There was no in-hospital or 90-day mortality. Two patients experienced late DSWI recurrence. All-cause mortality was 4.8% during a median follow-up of 2.5 years. ConclusionVancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.The protocol for this study was registered at ClinicalTrials.gov on July 16, 2024 (NCT06506032). ConclusionVancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.The protocol for this study was registered at ClinicalTrials.gov on July 16, 2024 (NCT06506032).

Citovat

KOLEK, Martin; Jana DURICOVA; Hana BROZMANOVA; Pavel SISTIK; Jan JUŘICA; Klara KANKOVA; Oldrich MOTYKA a Ivana KACIROVA. Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection. Annals of Medicine. ABINGDON: TAYLOR & FRANCIS LTD, 2025, roč. 57, č. 1, s. 1-8. ISSN 0785-3890. Dostupné z: https://doi.org/10.1080/07853890.2024.2444544.

@article{2468167,
   author = {Kolek, Martin and Duricova, Jana and Brozmanova, Hana and Sistik, Pavel and Juřica, Jan and Kankova, Klara and Motyka, Oldrich and Kacirova, Ivana},
   article_location = {ABINGDON},
   article_number = {1},
   doi = {https://doi.org/10.1080/07853890.2024.2444544},
   keywords = {Deep sternal wound infection; exudate; negative pressure wound therapy; open-heart surgery; vancomycin; wound penetration},
   language = {eng},
   issn = {0785-3890},
   journal = {Annals of Medicine},
   title = {Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection},
   url = {https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2444544},
   volume = {57},
   year = {2025}
}

TY  - JOUR
ID  - 2468167
AU  - Kolek, Martin - Duricova, Jana - Brozmanova, Hana - Sistik, Pavel - Juřica, Jan - Kankova, Klara - Motyka, Oldrich - Kacirova, Ivana
PY  - 2025
TI  - Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection
JF  - Annals of Medicine
VL  - 57
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - TAYLOR & FRANCIS LTD
SN  - 07853890
KW  - Deep sternal wound infection
KW  - exudate
KW  - negative pressure wound therapy
KW  - open-heart surgery
KW  - vancomycin
KW  - wound penetration
UR  - https://www.tandfonline.com/doi/full/10.1080/07853890.2024.2444544
N2  - IntroductionIt is hypothesized that systemically administered antibiotics penetrate wound sites more effectively during negative pressure wound therapy (NPWT). However, there is a lack of clinical data from patients who receive NPWT for deep sternal wound infection (DSWI) after open-heart surgery. Here, we evaluated vancomycin penetration into exudate in this patient group. Patients and methodsFor this prospective observational study, we enrolled 10 consecutive patients treated with NPWT for post-sternotomy DSWI. On the first sampling day, serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3 and 6 h after vancomycin administration. On the following three consecutive days, additional samples were collected, only before vancomycin administration. ResultsThe ratio of average vancomycin concentration in wound exudate to in serum was higher for free (unbound) (1.51 +/- 0.53) than for total (bound + unbound) (0.91 +/- 0.29) concentration (p = 0.049). The percentage of free vancomycin was higher in wound exudate than serum (0.79 +/- 0.19 vs. 0.46 +/- 0.16; p = 0.04). Good vancomycin wound penetration was maintained on the following three days (vancomycin trough exudate-to-serum concentration ratio > 1). The total hospital stay was significantly longer in patients with DSWI (46 +/- 11.6 days) versus without DSWI (14 +/- 11.7 days) (p < 0.001). There was no in-hospital or 90-day mortality. Two patients experienced late DSWI recurrence. All-cause mortality was 4.8% during a median follow-up of 2.5 years. ConclusionVancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.The protocol for this study was registered at ClinicalTrials.gov on July 16, 2024 (NCT06506032). ConclusionVancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.The protocol for this study was registered at ClinicalTrials.gov on July 16, 2024 (NCT06506032).
ER  -

KOLEK, Martin; Jana DURICOVA; Hana BROZMANOVA; Pavel SISTIK; Jan JUŘICA; Klara KANKOVA; Oldrich MOTYKA a Ivana KACIROVA. Vancomycin wound penetration in open-heart surgery patients receiving negative pressure wound therapy for deep sternal wound infection. \textit{Annals of Medicine}. ABINGDON: TAYLOR \&{} FRANCIS LTD, 2025, roč.~57, č.~1, s.~1-8. ISSN~0785-3890. Dostupné z: https://doi.org/10.1080/07853890.2024.2444544.

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