2023
What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects
FOITOVÁ, Ivona; Bohumil SAK; Radka PECKOVÁ; Wisnu NURCAHYO; Alena KADLECOVÁ et al.Základní údaje
Originální název
What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects
Autoři
FOITOVÁ, Ivona; Bohumil SAK; Radka PECKOVÁ; Wisnu NURCAHYO; Alena KADLECOVÁ a Karel DOLEŽAL
Vydání
2023
Další údaje
Jazyk
angličtina
Typ výsledku
Prezentace na konferencích
Obor
30310 Parasitology
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14310/23:00139717
Organizační jednotka
Přírodovědecká fakulta
Klíčová slova anglicky
Anti-parasitic activity; Waterborne protozoal diseases (WBD); Self-medication; Plant extracts
Změněno: 20. 1. 2025 11:58, Mgr. Radka Pecková, Ph.D.
Anotace
V originále
The main aim of this work is the isolation, identification and examination of bioactive plant fractions with potential antiparasitic activity. These extracts are obtained from plants that are routinely eaten by orangutans. Our previous research suggests that the purpose of this consumption is self-medication. The main criteria for the plant selection are the behavioral data of the orangutans and the parasite infections thereof. The effect of these extracts on the progression of significant waterborne protozoal diseases (WBD), namely amoebiasis and giardiasis, is tested using both in vitro and in vivo methods. Moreover, the anthelmintic properties of the selected extract are investigated in vivo in a model nematode, Caenorhabditis elegans. Subsequently, activityguided fractionation is performed and active substances from these extracts are isolated and their chemical structure and biological activities are characterized.
Návaznosti
| GA23-06571S, projekt VaV |
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