The interplay between microbiome and host factors in
pathogenesis and therapy of head and neck cancer

J 2024

The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer

RAUDENSKÁ, Martina; Mária BUGAJOVÁ; David KALFERT; Jan PLZAK; Adam SUBRT et al.

Základní údaje

Originální název

The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer

Autoři

RAUDENSKÁ, Martina ; Mária BUGAJOVÁ ; David KALFERT; Jan PLZAK; Adam SUBRT; Petra TESAROVA a Michal MASAŘÍK

Vydání

Biochimica et Biophysica Acta - Reviews on Cancer, Amsterdam, Elsevier Science BV, 2024, 0304-419X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.300

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/24:00138595

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Head and neck squamous cell carcinoma; Oral microbiome; Intestinal microbiome; Microbial metabolites; Oral mucositis; Radiotherapy

Štítky

14110515, 14110518

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 1. 2025 11:00, Mgr. Tereza Miškechová

Anotace

V originále

Heterogeneous cancers that lack strong driver mutations with high penetrance, such as head and neck squamous cell carcinoma (HNSCC), present unique challenges to understanding their aetiology due to the complex interactions between genetics and environmental factors. The interplay between lifestyle factors (such as poor oral hygiene, smoking, or alcohol consumption), the oral and gut microbiome, and host genetics appears particularly important in the context of HNSCC. The complex interplay between the gut microbiota and cancer treatment outcomes has also received increasing attention in recent years. This review article describes the bidirectional communication between the host and the oral/gut microbiome, focusing on microbiome-derived metabolites and their impact on systemic immune responses and the modulation of the tumour microenvironment. In addition, we review the role of host lifestyle factors in shaping the composition of the oral/gut microbiota and its impact on cancer progression and therapy. Overall, this review highlights the rationality of considering the oral/gut microbiota as a critical determinant of cancer therapy outcomes and points to therapeutic opportunities offered by targeting the oral/gut microbiota in the management of HNSCC.

Návaznosti

FW10010249, projekt VaV

Název: Nový diagnostický nástroj pro stanovování intratumorálního mikrobiomu

Investor: Technologická agentura ČR, Nový diagnostický nástroj pro stanovování intratumorálního mikrobiomu

MUNI/A/1587/2023, interní kód MU

Název: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masarykova univerzita, Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

NU23-03-00274, projekt VaV

Název: Složení ústního a střevního mikrobiomu jako prediktor odpovědi na léčbu u pacientů s karcinomem hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Složení ústního a střevního mikrobiomu jako prediktor odpovědi na léčbu u pacientů s karcinomem hlavy a krku

Citovat

RAUDENSKÁ, Martina; Mária BUGAJOVÁ; David KALFERT; Jan PLZAK; Adam SUBRT; Petra TESAROVA a Michal MASAŘÍK. The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer. Biochimica et Biophysica Acta - Reviews on Cancer. Amsterdam: Elsevier Science BV, 2024, roč. 1879, č. 6, s. 1-19. ISSN 0304-419X. Dostupné z: https://doi.org/10.1016/j.bbcan.2024.189216.

@article{2470312,
   author = {Raudenská, Martina and Bugajová, Mária and Kalfert, David and Plzak, Jan and Subrt, Adam and Tesarova, Petra and Masařík, Michal},
   article_location = {Amsterdam},
   article_number = {6},
   doi = {https://doi.org/10.1016/j.bbcan.2024.189216},
   keywords = {Head and neck squamous cell carcinoma; Oral microbiome; Intestinal microbiome; Microbial metabolites; Oral mucositis; Radiotherapy},
   language = {eng},
   issn = {0304-419X},
   journal = {Biochimica et Biophysica Acta - Reviews on Cancer},
   title = {The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer},
   url = {https://www.sciencedirect.com/science/article/pii/S0304419X24001471?via%3Dihub},
   volume = {1879},
   year = {2024}
}

TY  - JOUR
ID  - 2470312
AU  - Raudenská, Martina - Bugajová, Mária - Kalfert, David - Plzak, Jan - Subrt, Adam - Tesarova, Petra - Masařík, Michal
PY  - 2024
TI  - The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer
JF  - Biochimica et Biophysica Acta - Reviews on Cancer
VL  - 1879
IS  - 6
SP  - 1-19
EP  - 1-19
PB  - Elsevier Science BV
SN  - 0304419X
KW  - Head and neck squamous cell carcinoma
KW  - Oral microbiome
KW  - Intestinal microbiome
KW  - Microbial metabolites
KW  - Oral mucositis
KW  - Radiotherapy
UR  - https://www.sciencedirect.com/science/article/pii/S0304419X24001471?via%3Dihub
N2  - Heterogeneous cancers that lack strong driver mutations with high penetrance, such as head and neck squamous cell carcinoma (HNSCC), present unique challenges to understanding their aetiology due to the complex interactions between genetics and environmental factors. The interplay between lifestyle factors (such as poor oral hygiene, smoking, or alcohol consumption), the oral and gut microbiome, and host genetics appears particularly important in the context of HNSCC. The complex interplay between the gut microbiota and cancer treatment outcomes has also received increasing attention in recent years. This review article describes the bidirectional communication between the host and the oral/gut microbiome, focusing on microbiome-derived metabolites and their impact on systemic immune responses and the modulation of the tumour microenvironment. In addition, we review the role of host lifestyle factors in shaping the composition of the oral/gut microbiota and its impact on cancer progression and therapy. Overall, this review highlights the rationality of considering the oral/gut microbiota as a critical determinant of cancer therapy outcomes and points to therapeutic opportunities offered by targeting the oral/gut microbiota in the management of HNSCC.
ER  -

RAUDENSKÁ, Martina; Mária BUGAJOVÁ; David KALFERT; Jan PLZAK; Adam SUBRT; Petra TESAROVA a Michal MASAŘÍK. The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer. \textit{Biochimica et Biophysica Acta - Reviews on Cancer}. Amsterdam: Elsevier Science BV, 2024, roč.~1879, č.~6, s.~1-19. ISSN~0304-419X. Dostupné z: https://doi.org/10.1016/j.bbcan.2024.189216.

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