Pentamethinium Salts, New Inhibitors of Cancer Cell Migration

k 2022

Pentamethinium Salts, New Inhibitors of Cancer Cell Migration

PETRLÁKOVÁ, Kateřina; Jindřiška LEISCHNER FIALOVÁ; Jiří NAVRÁTIL; M JAKUBEK; Michal MASAŘÍK et al.

Základní údaje

Originální název

Pentamethinium Salts, New Inhibitors of Cancer Cell Migration

Autoři

PETRLÁKOVÁ, Kateřina ; Jindřiška LEISCHNER FIALOVÁ; Jiří NAVRÁTIL ; M JAKUBEK a Michal MASAŘÍK

Vydání

EMBO: Humanized mice, personalized therapies and big data, 2022, 2022

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Změněno: 27. 1. 2025 10:44, Mgr. Tereza Miškechová

Anotace

V originále

In solid tumors, invasiveness and metastasis contribute to over 90% of cancer-related deaths. Despite advancements in cancer treatment, effective drugs specifically targeting these processes remain unavailable. While cytostatic therapies aim to inhibit tumor cell growth and division, migrastatic treatments focus on preventing cell movement, local invasion, and metastasis. The most effective approach would likely involve a combination of both strategies. Pentamethinium salts (PMS) are a class of fluorescent compounds with varying cytotoxicity, depending on their molecular structure, that can influence tumor cell migration. Certain fluorescent dyes from the pentamethinium family demonstrate high affinity and specificity for cardiolipin in the inner mitochondrial membrane, offering excellent photostability, strong fluorescence properties, and low phototoxicity. At nanomolar concentrations, these dyes enable selective imaging of mitochondria in both live and fixed cells across different cell lines. Their minimal toxicity and precise localization allow for the study of mitochondrial morphology, structural complexity, and dynamics, which are crucial in various pathological conditions. This study aims to confirm the migrastatic potential of selected pentamethinium salts. Future research will focus on validating these findings in vivo, with the hypothesis that administering these compounds could prevent metastasis in a murine model of mammary carcinoma.

Citovat

PETRLÁKOVÁ, Kateřina; Jindřiška LEISCHNER FIALOVÁ; Jiří NAVRÁTIL; M JAKUBEK a Michal MASAŘÍK. Pentamethinium Salts, New Inhibitors of Cancer Cell Migration. In EMBO: Humanized mice, personalized therapies and big data, 2022. 2022.

@proceedings{2471504,
   author = {Petrláková, Kateřina and Leischner Fialová, Jindřiška and Navrátil, Jiří and Jakubek, M and Masařík, Michal},
   booktitle = {EMBO: Humanized mice, personalized therapies and big data, 2022},
   language = {eng},
   title = {Pentamethinium Salts, New Inhibitors of Cancer Cell Migration},
   year = {2022}
}

TY  - CONF
ID  - 2471504
AU  - Petrláková, Kateřina - Leischner Fialová, Jindřiška - Navrátil, Jiří - Jakubek, M - Masařík, Michal
PY  - 2022
TI  - Pentamethinium Salts, New Inhibitors of Cancer Cell Migration
N2  - In solid tumors, invasiveness and metastasis contribute to over 90% of cancer-related deaths. Despite advancements in cancer treatment, effective drugs specifically targeting these processes remain unavailable. While cytostatic therapies aim to inhibit tumor cell growth and division, migrastatic treatments focus on preventing cell movement, local invasion, and metastasis. The most effective approach would likely involve a combination of both strategies. Pentamethinium salts (PMS) are a class of fluorescent compounds with varying cytotoxicity, depending on their molecular structure, that can influence tumor cell migration. Certain fluorescent dyes from the pentamethinium family demonstrate high affinity and specificity for cardiolipin in the inner mitochondrial membrane, offering excellent photostability, strong fluorescence properties, and low phototoxicity. At nanomolar concentrations, these dyes enable selective imaging of mitochondria in both live and fixed cells across different cell lines. Their minimal toxicity and precise localization allow for the study of mitochondrial morphology, structural complexity, and dynamics, which are crucial in various pathological conditions. This study aims to confirm the migrastatic potential of selected pentamethinium salts. Future research will focus on validating these findings in vivo, with the hypothesis that administering these compounds could prevent metastasis in a murine model of mammary carcinoma.
ER  -

PETRLÁKOVÁ, Kateřina; Jindřiška LEISCHNER FIALOVÁ; Jiří NAVRÁTIL; M JAKUBEK a Michal MASAŘÍK. Pentamethinium Salts, New Inhibitors of Cancer Cell Migration. In \textit{EMBO: Humanized mice, personalized therapies and big data, 2022}. 2022.

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