Exploring migrastatic compounds: A mitochondrial approach to
inhibit cancer cell migration

a 2023

Exploring migrastatic compounds: A mitochondrial approach to inhibit cancer cell migration

PETRLÁKOVÁ, Kateřina; Jiří NAVRÁTIL; Milan JAKUBEK a Michal MASAŘÍK

Základní údaje

Originální název

Exploring migrastatic compounds: A mitochondrial approach to inhibit cancer cell migration

Autoři

PETRLÁKOVÁ, Kateřina; Jiří NAVRÁTIL ; Milan JAKUBEK a Michal MASAŘÍK

Vydání

XXII. setkání biochemiků a molekulárních biologů, 2023, 2023

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

Změněno: 27. 1. 2025 12:43, Ing. Kateřina Hönigová

Anotace

V originále

In solid tumors, invasiveness and metastasis are responsible for more than 90% of deaths. Even though cancer treatment is at a high level today, the category of drugs against invasiveness and metastasis is still missing. While the aim of cytostatic treatment is to prevent the growth and division of tumor cells, the goal of migrastatic treatment is to prevent the tumor cells from moving, local invasiveness, and metastasis. The best solution would be a combination of these approaches. Here we introduce new compounds belonging to the group of migrastatics. Pentamethinium salts (PMS) are a group of compounds characterized by fluorescence and variable cytotoxicity depending on the structure of the molecule and can play an important role in influencing the migration potential of tumor cells. Specific fluorescent dyes from the pentamethinium family exhibit exceptional affinity and selectivity for cardiolipin in the inner mitochondrial membrane and have excellent photostability, fluorescence properties, and low phototoxicity. Our previous study revealed the inhibitory effect of PMS on DHODH-dependent respiration, a critical step in pyrimidine synthesis. Here, we present the binding of BCV 141 to mitochondria of cancer cells, the inhibition of OXPHOS and overall ATP production, molecular docking with binding to DHODH and IL-6 receptor, migrastatic potential, and inhibition of metastatic seeding in the lungs of mice.

Citovat

PETRLÁKOVÁ, Kateřina; Jiří NAVRÁTIL; Milan JAKUBEK a Michal MASAŘÍK. Exploring migrastatic compounds: A mitochondrial approach to inhibit cancer cell migration. In XXII. setkání biochemiků a molekulárních biologů, 2023. 2023.

@proceedings{2471507,
   author = {Petrláková, Kateřina and Navrátil, Jiří and Jakubek, Milan and Masařík, Michal},
   booktitle = {XXII. setkání biochemiků a molekulárních biologů, 2023},
   language = {eng},
   title = {Exploring migrastatic compounds: A mitochondrial approach to inhibit cancer cell migration},
   year = {2023}
}

TY  - CONF
ID  - 2471507
AU  - Petrláková, Kateřina - Navrátil, Jiří - Jakubek, Milan - Masařík, Michal
PY  - 2023
TI  - Exploring migrastatic compounds: A mitochondrial approach to inhibit cancer cell migration
N2  - In solid tumors, invasiveness and metastasis are responsible for more than 90% of deaths. Even though cancer treatment is at a high level today, the category of drugs against invasiveness and metastasis is still missing. While the aim of cytostatic treatment is to prevent the growth and division of tumor cells, the goal of migrastatic treatment is to prevent the tumor cells from moving, local invasiveness, and metastasis. The best solution would be a combination of these approaches. Here we introduce new compounds belonging to the group of migrastatics. Pentamethinium salts (PMS) are a group of compounds characterized by fluorescence and variable cytotoxicity depending on the structure of the molecule and can play an important role in influencing the migration potential of tumor cells. Specific fluorescent dyes from the pentamethinium family exhibit exceptional affinity and selectivity for cardiolipin in the inner mitochondrial membrane and have excellent photostability, fluorescence properties, and low phototoxicity. Our previous study revealed the inhibitory effect of PMS on DHODH-dependent respiration, a critical step in pyrimidine synthesis. Here, we present the binding of BCV 141 to mitochondria of cancer cells, the inhibition of OXPHOS and overall ATP production, molecular docking with binding to DHODH and IL-6 receptor, migrastatic potential, and inhibition of metastatic seeding in the lungs of mice.
ER  -

PETRLÁKOVÁ, Kateřina; Jiří NAVRÁTIL; Milan JAKUBEK a Michal MASAŘÍK. Exploring migrastatic compounds: A mitochondrial approach to inhibit cancer cell migration. In \textit{XXII. setkání biochemiků a molekulárních biologů, 2023}. 2023.

Přehled o publikaci