Analysis of the oral and intestinal microbiome composition in
patients with head and neck cancer

k 2024

Analysis of the oral and intestinal microbiome composition in patients with head and neck cancer

BUGAJOVÁ, Mária; Martina RAUDENSKÁ; David KALFEŘT; Jan PLZÁK; František PETRLÁK et al.

Základní údaje

Originální název

Analysis of the oral and intestinal microbiome composition in patients with head and neck cancer

Autoři

BUGAJOVÁ, Mária ; Martina RAUDENSKÁ ; David KALFEŘT; Jan PLZÁK; František PETRLÁK; Michal BOČEK a Michal MASAŘÍK

Vydání

XXVII: Biologické dny: Tkáňové mikroprostředí (4.9.2024, Brno), 2024

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

intestinal microbiome composition; head and neck cancer

Změněno: 27. 1. 2025 11:01, Mgr. Tereza Miškechová

Anotace

V originále

Head and neck squamous cell carcinomas (HNSCC), arising from the mucosal epithelium of the oral cavity, pharynx, and larynx, are the sixth most common cancer worldwide. Alongside smoking, chewing tobacco, heavy alcohol use, and poor oral hygiene, evidence increasingly suggests that polymorphic variability in individual microbiomes can significantly impact cancer phenotypes. The composition of the microbiome, including bacteria, mycoplasmas, viruses, bacteriophages, and archaea, has attracted growing interest due to its potential roles in the development, progression, and treatment of HNSCC. Dysbiosis, an overgrowth of harmful microbes relative to beneficial ones, is associated with chronic inflammation, DNA damage, and immune dysregulation, contributing to cancer development. For instance, alterations in oral bacteria, such as Fusobacteria and Streptococcus, have been identified as potential prognostic biomarkers in HNSCC. In addition, it is also necessary to focus on the gut microbiome, which may initially seem unrelated to tumours in the head and neck region. Microbe-influenced metabolites like inosine, kynurenine, serotonin, shortchain fatty acids, and bile acids can enter the bloodstream and potentially shape the tumour microenvironment (TME) by interacting with receptors on cancer and immune cells. Lastly, the translocation of dysbiotic oral bacteria to the gut can also lead to pathological changes in the gut microbiome. In summary, the interplay between the microbiome and HNSCC pathogenesis highlights the disease's complexity, with dysbiosis in oral and gut microbiota, influenced by diet, lifestyle, and medical interventions, contributing to inflammation, immune dysregulation, metabolic changes, and tumor development.

Návaznosti

MUNI/A/1587/2023, interní kód MU

Název: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masarykova univerzita, Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

NU23-03-00274, projekt VaV

Název: Složení ústního a střevního mikrobiomu jako prediktor odpovědi na léčbu u pacientů s karcinomem hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Složení ústního a střevního mikrobiomu jako prediktor odpovědi na léčbu u pacientů s karcinomem hlavy a krku

Citovat

BUGAJOVÁ, Mária; Martina RAUDENSKÁ; David KALFEŘT; Jan PLZÁK; František PETRLÁK; Michal BOČEK a Michal MASAŘÍK. Analysis of the oral and intestinal microbiome composition in patients with head and neck cancer. In XXVII: Biologické dny: Tkáňové mikroprostředí (4.9.2024, Brno). 2024.

@proceedings{2471510,
   author = {Bugajová, Mária and Raudenská, Martina and Kalfeřt, David and Plzák, Jan and Petrlák, František and Boček, Michal and Masařík, Michal},
   booktitle = {XXVII: Biologické dny: Tkáňové mikroprostředí (4.9.2024, Brno)},
   keywords = {intestinal microbiome composition; head and neck cancer},
   language = {eng},
   title = {Analysis of the oral and intestinal microbiome composition in patients with head and neck cancer},
   year = {2024}
}

TY  - CONF
ID  - 2471510
AU  - Bugajová, Mária - Raudenská, Martina - Kalfeřt, David - Plzák, Jan - Petrlák, František - Boček, Michal - Masařík, Michal
PY  - 2024
TI  - Analysis of the oral and intestinal microbiome composition in patients with head and neck cancer
KW  - intestinal microbiome composition
KW  - head and neck cancer
N2  - Head and neck squamous cell carcinomas (HNSCC), arising from the mucosal epithelium of the oral cavity, pharynx, and larynx, are the sixth most common cancer worldwide. Alongside smoking, chewing tobacco, heavy alcohol use, and poor oral hygiene, evidence increasingly suggests that polymorphic variability in individual microbiomes can significantly impact cancer phenotypes. The composition of the microbiome, including bacteria, mycoplasmas, viruses, bacteriophages, and archaea, has attracted growing interest due to its potential roles in the development, progression, and treatment of HNSCC. Dysbiosis, an overgrowth of harmful microbes relative to beneficial ones, is associated with chronic inflammation, DNA damage, and immune dysregulation, contributing to cancer development. For instance, alterations in oral bacteria, such as Fusobacteria and Streptococcus, have been identified as potential prognostic biomarkers in HNSCC. In addition, it is also necessary to focus on the gut microbiome, which may initially seem unrelated to tumours in the head and neck region. Microbe-influenced metabolites like inosine, kynurenine, serotonin, shortchain fatty acids, and bile acids can enter the bloodstream and potentially shape the tumour microenvironment (TME) by interacting with receptors on cancer and immune cells. Lastly, the translocation of dysbiotic oral bacteria to the gut can also lead to pathological changes in the gut microbiome. In summary, the interplay between the microbiome and HNSCC pathogenesis highlights the disease's complexity, with dysbiosis in oral and gut microbiota, influenced by diet, lifestyle, and medical interventions, contributing to inflammation, immune dysregulation, metabolic changes, and tumor development.
ER  -

BUGAJOVÁ, Mária; Martina RAUDENSKÁ; David KALFEŘT; Jan PLZÁK; František PETRLÁK; Michal BOČEK a Michal MASAŘÍK. Analysis of the oral and intestinal microbiome composition in patients with head and neck cancer. In \textit{XXVII: Biologické dny: Tkáňové mikroprostředí (4.9.2024, Brno)}. 2024.

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