Significance of F-18 FDG PET/MRI in the search for the etiology
of inflammation of unclear origin and fever of unknown origin

J 2024

Significance of F-18 FDG PET/MRI in the search for the etiology of inflammation of unclear origin and fever of unknown origin

ROHAN, Tomáš; Petr HLOŽANKA; Marek DOSTÁL; Tomáš MACEK; Zdeněk FOJTÍK et. al.

Základní údaje

Originální název

Significance of F-18 FDG PET/MRI in the search for the etiology of inflammation of unclear origin and fever of unknown origin

Autoři

ROHAN, Tomáš (203 Česká republika, domácí); Petr HLOŽANKA (203 Česká republika); Marek DOSTÁL (203 Česká republika, domácí); Tomáš MACEK (203 Česká republika, domácí); Zdeněk FOJTÍK (203 Česká republika, domácí); Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Česká republika, domácí) a Miloš KEŘKOVSKÝ (203 Česká republika, domácí)

Vydání

European journal of radiology, Ireland, Elsevier Science Ireland Ltd, 2024, 0720-048X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.200 v roce 2023

Kód RIV

RIV/00216224:14110/24:00138703

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ejrad.2023.111281

UT WoS

001161439500001

EID Scopus

2-s2.0-85182565867

Klíčová slova anglicky

Fever of unknown origin; Positron -Emission Tomography; Magnetic Resonance Imaging; Multimodal Imaging; Fluorodeoxyglucose F18

Štítky

14110212, 14110216, 14110511, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 4. 2025 13:29, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: To evaluate the contribution of F-18 FDG-PET/MRI in the search for the etiology of the inflammation of unknown origin (IUO) and fever of unknown origin (FUO). Material and methods: The study included 104 patients who underwent F-18 FDG-PET/MRI for IUO or FUO. The sensitivity, specificity, predictive values of the PET/MRI findings in relation to the final diagnosis of IUO/FUO were evaluated. A five-point Likert scale was used to semiquantitatively assess the probability of the cause of IUO/FUO based on PET/MRI finding. Furthermore, clinical (fever, arthralgia, weight loss, night sweats, age) and laboratory (C-reactive protein, leukocytes) parameters were monitored and compared with the true positivity rate of PET/MRI. Results: In patients with definitively identified etiology of FUO and IUO, FDG-PET/MRI achieved a sensitivity of 96 %, specificity of 82 %, and positive and negative predictive values of 92 and 90 %. The cause of the IUO was determined in 71 patients (68.3 %). In 33 (31.7 %) patients, the etiology of IUO/FUO remained unknown, while in 25 (75.8 %) of them the symptoms resolved spontaneously and in 8 (24.2 %) patients they persisted without explanation even after 12 months of the follow-up. The most significant parameter in relation to subsequent PET/ MRI finding was increased level of CRP, which was present in 96 % of true positive PET/MRI and normal CRP level was present in 56 % of true negative PET/MRI. Conclusion: Based on this study, FDG-PET/MRI is a suitable alternative for the investigation of IUO/FUO, this imaging technique has a very high sensitivity and negative predictive value.

Návaznosti

MUNI/A/1611/2023, interní kód MU

Název: Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

Investor: Masarykova univerzita, Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

Citovat

ROHAN, Tomáš; Petr HLOŽANKA; Marek DOSTÁL; Tomáš MACEK; Zdeněk FOJTÍK; Andrea ŠPRLÁKOVÁ-PUKOVÁ a Miloš KEŘKOVSKÝ. Significance of F-18 FDG PET/MRI in the search for the etiology of inflammation of unclear origin and fever of unknown origin. European journal of radiology. Ireland: Elsevier Science Ireland Ltd, 2024, roč. 171, February 2024, s. 1-6. ISSN 0720-048X. Dostupné z: https://dx.doi.org/10.1016/j.ejrad.2023.111281.

@article{2472576,
   author = {Rohan, Tomáš and Hložanka, Petr and Dostál, Marek and Macek, Tomáš and Fojtík, Zdeněk and ŠprlákováandPuková, Andrea and Keřkovský, Miloš},
   article_location = {Ireland},
   article_number = {February 2024},
   doi = {http://dx.doi.org/10.1016/j.ejrad.2023.111281},
   keywords = {Fever of unknown origin; Positron -Emission Tomography; Magnetic Resonance Imaging; Multimodal Imaging; Fluorodeoxyglucose F18},
   language = {eng},
   issn = {0720-048X},
   journal = {European journal of radiology},
   title = {Significance of F-18 FDG PET/MRI in the search for the etiology of inflammation of unclear origin and fever of unknown origin},
   url = {https://www.sciencedirect.com/science/article/pii/S0720048X23005958},
   volume = {171},
   year = {2024}
}

TY  - JOUR
ID  - 2472576
AU  - Rohan, Tomáš - Hložanka, Petr - Dostál, Marek - Macek, Tomáš - Fojtík, Zdeněk - Šprláková-Puková, Andrea - Keřkovský, Miloš
PY  - 2024
TI  - Significance of F-18 FDG PET/MRI in the search for the etiology of inflammation of unclear origin and fever of unknown origin
JF  - European journal of radiology
VL  - 171
IS  - February 2024
SP  - 1-6
EP  - 1-6
PB  - Elsevier Science Ireland Ltd
SN  - 0720048X
KW  - Fever of unknown origin
KW  - Positron -Emission Tomography
KW  - Magnetic Resonance Imaging
KW  - Multimodal Imaging
KW  - Fluorodeoxyglucose F18
UR  - https://www.sciencedirect.com/science/article/pii/S0720048X23005958
N2  - Purpose: To evaluate the contribution of F-18 FDG-PET/MRI in the search for the etiology of the inflammation of unknown origin (IUO) and fever of unknown origin (FUO). Material and methods: The study included 104 patients who underwent F-18 FDG-PET/MRI for IUO or FUO. The sensitivity, specificity, predictive values of the PET/MRI findings in relation to the final diagnosis of IUO/FUO were evaluated. A five-point Likert scale was used to semiquantitatively assess the probability of the cause of IUO/FUO based on PET/MRI finding. Furthermore, clinical (fever, arthralgia, weight loss, night sweats, age) and laboratory (C-reactive protein, leukocytes) parameters were monitored and compared with the true positivity rate of PET/MRI. Results: In patients with definitively identified etiology of FUO and IUO, FDG-PET/MRI achieved a sensitivity of 96 %, specificity of 82 %, and positive and negative predictive values of 92 and 90 %. The cause of the IUO was determined in 71 patients (68.3 %). In 33 (31.7 %) patients, the etiology of IUO/FUO remained unknown, while in 25 (75.8 %) of them the symptoms resolved spontaneously and in 8 (24.2 %) patients they persisted without explanation even after 12 months of the follow-up. The most significant parameter in relation to subsequent PET/ MRI finding was increased level of CRP, which was present in 96 % of true positive PET/MRI and normal CRP level was present in 56 % of true negative PET/MRI. Conclusion: Based on this study, FDG-PET/MRI is a suitable alternative for the investigation of IUO/FUO, this imaging technique has a very high sensitivity and negative predictive value.
ER  -

ROHAN, Tomáš; Petr HLOŽANKA; Marek DOSTÁL; Tomáš MACEK; Zdeněk FOJTÍK; Andrea ŠPRLÁKOVÁ-PUKOVÁ a Miloš KEŘKOVSKÝ. Significance of F-18 FDG PET/MRI in the search for the etiology of inflammation of unclear origin and fever of unknown origin. \textit{European journal of radiology}. Ireland: Elsevier Science Ireland Ltd, 2024, roč.~171, February 2024, s.~1-6. ISSN~0720-048X. Dostupné z: https://dx.doi.org/10.1016/j.ejrad.2023.111281.

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