Design of Polymeric Nanoparticles for Theranostic Delivery of
Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped
Graphene Quantum Dots

J 2024

Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots

KUCUKTURKMEN, Berrin; Umut Can OZ; Engin ER; Jennifer GOMÉZ; Seda Ipek TEKNECI et. al.

Základní údaje

Originální název

Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots

Autoři

KUCUKTURKMEN, Berrin; Umut Can OZ; Engin ER; Jennifer GOMÉZ; Seda Ipek TEKNECI; Ozgur ESIM; Umut Ugur OZKOSE; Sevgi GULYUZ; Aylin USTUNDAG; Ozgur YILMAZ; Lenka ZAJÍČKOVÁ a Asuman BOZKIR

Vydání

Macromolecular Bioscience, Wiley, 2024, 1616-5187

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10305 Fluids and plasma physics

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100

Kód RIV

RIV/00216224:14310/24:00138705

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1002/mabi.202400149

UT WoS

001241770700001

EID Scopus

2-s2.0-85195504695

Klíčová slova anglicky

amphiphilic block copolymers; Capsaicin; nanoparticle; N-GQDs; theranostic

Štítky

14312020, CF CELLIM, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 3. 2025 08:21, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

In recent years, multifunctional nanocarriers that provide simultaneous drug delivery and imaging have attracted enormous attention, especially in cancer treatment. In this research, a biocompatible fluorescent multifunctional nanocarrier is designed for the co-delivery of capsaicin (CPS) and nitrogen-doped graphene quantum dots (N-GQDs) using the pH sensitive amphiphilic block copolymer (poly(2-ethyl-2-oxazoline)-b-poly(ε-caprolactone), PEtOx-b-PCL). The effects of the critical formulation parameters (the amount of copolymer, the concentration of poly(vinyl alcohol) (PVA) as a stabilizing agent in the inner aqueous phase, and volume of the inner phase) are evaluated to achieve optimal nanoparticle (NP) properties using Central Composite Design. The optimized NPs demonstrated a desirable size distribution (167.8 ± 1.4 nm) with a negative surface charge (−19.9 ± 0.4) and a suitable loading capacity for CPS (70.80 ± 0.05%). The CPS & N-GQD NPs are found to have remarkable toxicity on human breast adenocarcinoma cell line (MCF-7). The solid fluorescent signal is acquired from cells containing multifunctional NPs, according to the confocal microscope imaging results, confirming the significant cellular uptake. This research illustrates the enormous potential for cellular imaging and enhanced cancer therapy offered by multifunctional nanocarriers that combine drug substances with the novel fluorescent agents.

Návaznosti

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

KUCUKTURKMEN, Berrin; Umut Can OZ; Engin ER; Jennifer GOMÉZ; Seda Ipek TEKNECI; Ozgur ESIM; Umut Ugur OZKOSE; Sevgi GULYUZ; Aylin USTUNDAG; Ozgur YILMAZ; Lenka ZAJÍČKOVÁ a Asuman BOZKIR. Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots. Macromolecular Bioscience. Wiley, 2024, roč. 24, č. 9, s. 1-13. ISSN 1616-5187. Dostupné z: https://doi.org/10.1002/mabi.202400149.

@article{2472614,
   author = {Kucukturkmen, Berrin and Oz, Umut Can and Er, Engin and Goméz, Jennifer and Tekneci, Seda Ipek and Esim, Ozgur and Ozkose, Umut Ugur and Gulyuz, Sevgi and Ustundag, Aylin and Yilmaz, Ozgur and Zajíčková, Lenka and Bozkir, Asuman},
   article_number = {9},
   doi = {https://doi.org/10.1002/mabi.202400149},
   keywords = {amphiphilic block copolymers; Capsaicin; nanoparticle; N-GQDs; theranostic},
   language = {eng},
   issn = {1616-5187},
   journal = {Macromolecular Bioscience},
   title = {Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400149},
   volume = {24},
   year = {2024}
}

TY  - JOUR
ID  - 2472614
AU  - Kucukturkmen, Berrin - Oz, Umut Can - Er, Engin - Goméz, Jennifer - Tekneci, Seda Ipek - Esim, Ozgur - Ozkose, Umut Ugur - Gulyuz, Sevgi - Ustundag, Aylin - Yilmaz, Ozgur - Zajíčková, Lenka - Bozkir, Asuman
PY  - 2024
TI  - Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
JF  - Macromolecular Bioscience
VL  - 24
IS  - 9
SP  - 1-13
EP  - 1-13
PB  - Wiley
SN  - 16165187
KW  - amphiphilic block copolymers
KW  - Capsaicin
KW  - nanoparticle
KW  - N-GQDs
KW  - theranostic
UR  - https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400149
N2  - In recent years, multifunctional nanocarriers that provide simultaneous drug delivery and imaging have attracted enormous attention, especially in cancer treatment. In this research, a biocompatible fluorescent multifunctional nanocarrier is designed for the co-delivery of capsaicin (CPS) and nitrogen-doped graphene quantum dots (N-GQDs) using the pH sensitive amphiphilic block copolymer (poly(2-ethyl-2-oxazoline)-b-poly(ε-caprolactone), PEtOx-b-PCL). The effects of the critical formulation parameters (the amount of copolymer, the concentration of poly(vinyl alcohol) (PVA) as a stabilizing agent in the inner aqueous phase, and volume of the inner phase) are evaluated to achieve optimal nanoparticle (NP) properties using Central Composite Design. The optimized NPs demonstrated a desirable size distribution (167.8 ± 1.4 nm) with a negative surface charge (−19.9 ± 0.4) and a suitable loading capacity for CPS (70.80 ± 0.05%). The CPS & N-GQD NPs are found to have remarkable toxicity on human breast adenocarcinoma cell line (MCF-7). The solid fluorescent signal is acquired from cells containing multifunctional NPs, according to the confocal microscope imaging results, confirming the significant cellular uptake. This research illustrates the enormous potential for cellular imaging and enhanced cancer therapy offered by multifunctional nanocarriers that combine drug substances with the novel fluorescent agents.
ER  -

KUCUKTURKMEN, Berrin; Umut Can OZ; Engin ER; Jennifer GOMÉZ; Seda Ipek TEKNECI; Ozgur ESIM; Umut Ugur OZKOSE; Sevgi GULYUZ; Aylin USTUNDAG; Ozgur YILMAZ; Lenka ZAJÍČKOVÁ a Asuman BOZKIR. Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots. \textit{Macromolecular Bioscience}. Wiley, 2024, roč.~24, č.~9, s.~1-13. ISSN~1616-5187. Dostupné z: https://doi.org/10.1002/mabi.202400149.

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