Influence of adjuvant type and route of administration on the
immunogenicity of Leishmania-derived tick-borne encephalitis
virus-like particles – A recombinant vaccine candidate

J 2024

Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate

ZIMNA, Marta; Gabriela BRZUSKA; Jiri SALAT; Daniel RŮŽEK; Ewelina KROL et al.

Základní údaje

Originální název

Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate

Autoři

ZIMNA, Marta; Gabriela BRZUSKA; Jiri SALAT; Daniel RŮŽEK a Ewelina KROL

Vydání

Antiviral Research, Elsevier, 2024, 0166-3542

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10607 Virology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.000

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00138747

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Tick -borne encephalitis virus; Virus -like particles; Vaccine; Adjuvants; Leishmania tarentolae

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2025 17:59, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Tick-borne encephalitis virus (TBEV) is a tick-borne flavivirus that induces severe central nervous system disorders. It has recently raised concerns due to an expanding geographical range and increasing infection rates. Existing vaccines, though effective, face low coverage rates in numerous TBEV endemic regions. Our previous work demonstrated the immunogenicity and full protection afforded by a TBEV vaccine based on virus-like particles (VLPs) produced in Leishmania tarentolae cells in immunization studies in a mouse model. In the present study, we explored the impact of adjuvants (AddaS03™, Alhydrogel®+MPLA) and administration routes (subcutaneous, intramuscular) on the immune response. Adjuvanted groups exhibited significantly enhanced antibody responses, higher avidity, and more balanced Th1/Th2 response. IFN-γ responses depended on the adjuvant type, while antibody levels were influenced by both adjuvant and administration routes. The combination of Leishmania-derived TBEV VLPs with Alhydrogel® and MPLA via intramuscular administration emerged as a highly promising prophylactic vaccine candidate, eliciting a robust, balanced immune response with substantial neutralization potential.

Citovat

ZIMNA, Marta; Gabriela BRZUSKA; Jiri SALAT; Daniel RŮŽEK a Ewelina KROL. Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate. Antiviral Research. Elsevier, 2024, roč. 228, August, s. 1-7. ISSN 0166-3542. Dostupné z: https://doi.org/10.1016/j.antiviral.2024.105941.

@article{2473056,
   author = {Zimna, Marta and Brzuska, Gabriela and Salat, Jiri and Růžek, Daniel and Krol, Ewelina},
   article_number = {August},
   doi = {https://doi.org/10.1016/j.antiviral.2024.105941},
   keywords = {Tick -borne encephalitis virus; Virus -like particles; Vaccine; Adjuvants; Leishmania tarentolae},
   language = {eng},
   issn = {0166-3542},
   journal = {Antiviral Research},
   title = {Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate},
   url = {https://www.sciencedirect.com/science/article/pii/S0166354224001505},
   volume = {228},
   year = {2024}
}

TY  - JOUR
ID  - 2473056
AU  - Zimna, Marta - Brzuska, Gabriela - Salat, Jiri - Růžek, Daniel - Krol, Ewelina
PY  - 2024
TI  - Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate
JF  - Antiviral Research
VL  - 228
IS  - August
SP  - 1-7
EP  - 1-7
PB  - Elsevier
SN  - 01663542
KW  - Tick -borne encephalitis virus
KW  - Virus -like particles
KW  - Vaccine
KW  - Adjuvants
KW  - Leishmania tarentolae
UR  - https://www.sciencedirect.com/science/article/pii/S0166354224001505
N2  - Tick-borne encephalitis virus (TBEV) is a tick-borne flavivirus that induces severe central nervous system disorders. It has recently raised concerns due to an expanding geographical range and increasing infection rates. Existing vaccines, though effective, face low coverage rates in numerous TBEV endemic regions. Our previous work demonstrated the immunogenicity and full protection afforded by a TBEV vaccine based on virus-like particles (VLPs) produced in Leishmania tarentolae cells in immunization studies in a mouse model. In the present study, we explored the impact of adjuvants (AddaS03™, Alhydrogel®+MPLA) and administration routes (subcutaneous, intramuscular) on the immune response. Adjuvanted groups exhibited significantly enhanced antibody responses, higher avidity, and more balanced Th1/Th2 response. IFN-γ responses depended on the adjuvant type, while antibody levels were influenced by both adjuvant and administration routes. The combination of Leishmania-derived TBEV VLPs with Alhydrogel® and MPLA via intramuscular administration emerged as a highly promising prophylactic vaccine candidate, eliciting a robust, balanced immune response with substantial neutralization potential.
ER  -

ZIMNA, Marta; Gabriela BRZUSKA; Jiri SALAT; Daniel RŮŽEK a Ewelina KROL. Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate. \textit{Antiviral Research}. Elsevier, 2024, roč.~228, August, s.~1-7. ISSN~0166-3542. Dostupné z: https://doi.org/10.1016/j.antiviral.2024.105941.

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