Mechanisms of Plasma Ozone and UV-C Sterilization of SARS-CoV-2
Explored through Atomic Force Microscopy.

J 2024

Mechanisms of Plasma Ozone and UV-C Sterilization of SARS-CoV-2 Explored through Atomic Force Microscopy.

BAE, Jinseung; Petr BEDNÁŘ; Rong ZHU; Cheolwoo BONG; Moon Soo BAK et al.

Základní údaje

Originální název

Mechanisms of Plasma Ozone and UV-C Sterilization of SARS-CoV-2 Explored through Atomic Force Microscopy.

Autoři

Vydání

ACS Applied Materials and Interfaces, American Chemical Society, 2024, 1944-8244

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10607 Virology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.200

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00138754

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

binding activity; infectivity test; sterilization mechanisms; structural characteristics; topographical characteristics

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 2. 2025 14:40, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Ultraviolet-C (UV-C) radiation and ozone gas are potential mechanisms employed to inactivate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), each exhibiting distinct molecular-level modalities of action. To elucidate these disparities and deepen our understanding, we delve into the intricacies of SARS-CoV-2 inactivation via UV-C and ozone gas treatments, exploring their distinct molecular-level impacts utilizing a suite of advanced techniques, including biological atomic force microscopy (Bio-AFM) and single virus force spectroscopy (SVFS). Whereas UV-C exhibited no perceivable alterations in virus size or surface topography, ozone gas treatment elucidated pronounced changes in both parameters, intensifying with prolonged exposure. Furthermore, a nuanced difference was observed in virus–host cell binding post-treatment: ozone gas distinctly reduced SARS-CoV-2 binding to host cells, while UV-C maintained the status quo. The results derived from these methodical explorations underscore the pivotal role of advanced Bio-AFM techniques and SVFS in enhancing our understanding of virus inactivation mechanisms, offering invaluable insights for future research and applications in viral contamination mitigation.

Citovat

BAE, Jinseung; Petr BEDNÁŘ; Rong ZHU; Cheolwoo BONG; Moon Soo BAK; Sarah STAINER; Kyoungjun KIM; Junghun LEE; Chulsoo YOON; Yugyeong LEE; Omobolaji Taye OJOWA; Maximilian LEHNER; Peter HINTERDORFER; Daniel RŮŽEK; Sungsu PARK a Yoo Jin OH. Mechanisms of Plasma Ozone and UV-C Sterilization of SARS-CoV-2 Explored through Atomic Force Microscopy. ACS Applied Materials and Interfaces. American Chemical Society, 2024, roč. 16, č. 37, s. 49176-49185. ISSN 1944-8244. Dostupné z: https://doi.org/10.1021/acsami.4c11057.

@article{2473183,
   author = {Bae, Jinseung and Bednář, Petr and Zhu, Rong and Bong, Cheolwoo and Bak, Moon Soo and Stainer, Sarah and Kim, Kyoungjun and Lee, Junghun and Yoon, Chulsoo and Lee, Yugyeong and Ojowa, Omobolaji Taye and Lehner, Maximilian and Hinterdorfer, Peter and Růžek, Daniel and Park, Sungsu and Oh, Yoo Jin},
   article_number = {37},
   doi = {https://doi.org/10.1021/acsami.4c11057},
   keywords = {binding activity; infectivity test; sterilization mechanisms; structural characteristics; topographical characteristics},
   language = {eng},
   issn = {1944-8244},
   journal = {ACS Applied Materials and Interfaces},
   title = {Mechanisms of Plasma Ozone and UV-C Sterilization of SARS-CoV-2 Explored through Atomic Force Microscopy.},
   url = {https://pubs.acs.org/doi/10.1021/acsami.4c11057},
   volume = {16},
   year = {2024}
}

TY  - JOUR
ID  - 2473183
AU  - Bae, Jinseung - Bednář, Petr - Zhu, Rong - Bong, Cheolwoo - Bak, Moon Soo - Stainer, Sarah - Kim, Kyoungjun - Lee, Junghun - Yoon, Chulsoo - Lee, Yugyeong - Ojowa, Omobolaji Taye - Lehner, Maximilian - Hinterdorfer, Peter - Růžek, Daniel - Park, Sungsu - Oh, Yoo Jin
PY  - 2024
TI  - Mechanisms of Plasma Ozone and UV-C Sterilization of SARS-CoV-2 Explored through Atomic Force Microscopy.
JF  - ACS Applied Materials and Interfaces
VL  - 16
IS  - 37
SP  - 49176-49185
EP  - 49176-49185
PB  - American Chemical Society
SN  - 19448244
KW  - binding activity
KW  - infectivity test
KW  - sterilization mechanisms
KW  - structural characteristics
KW  - topographical characteristics
UR  - https://pubs.acs.org/doi/10.1021/acsami.4c11057
N2  - Ultraviolet-C (UV-C) radiation and ozone gas are potential mechanisms employed to inactivate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), each exhibiting distinct molecular-level modalities of action. To elucidate these disparities and deepen our understanding, we delve into the intricacies of SARS-CoV-2 inactivation via UV-C and ozone gas treatments, exploring their distinct molecular-level impacts utilizing a suite of advanced techniques, including biological atomic force microscopy (Bio-AFM) and single virus force spectroscopy (SVFS). Whereas UV-C exhibited no perceivable alterations in virus size or surface topography, ozone gas treatment elucidated pronounced changes in both parameters, intensifying with prolonged exposure. Furthermore, a nuanced difference was observed in virus–host cell binding post-treatment: ozone gas distinctly reduced SARS-CoV-2 binding to host cells, while UV-C maintained the status quo. The results derived from these methodical explorations underscore the pivotal role of advanced Bio-AFM techniques and SVFS in enhancing our understanding of virus inactivation mechanisms, offering invaluable insights for future research and applications in viral contamination mitigation.
ER  -

BAE, Jinseung; Petr BEDNÁŘ; Rong ZHU; Cheolwoo BONG; Moon Soo BAK; Sarah STAINER; Kyoungjun KIM; Junghun LEE; Chulsoo YOON; Yugyeong LEE; Omobolaji Taye OJOWA; Maximilian LEHNER; Peter HINTERDORFER; Daniel RŮŽEK; Sungsu PARK a Yoo Jin OH. Mechanisms of Plasma Ozone and UV-C Sterilization of SARS-CoV-2 Explored through Atomic Force Microscopy. \textit{ACS Applied Materials and Interfaces}. American Chemical Society, 2024, roč.~16, č.~37, s.~49176-49185. ISSN~1944-8244. Dostupné z: https://doi.org/10.1021/acsami.4c11057.

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