Prognostic factors for survival in patients with advanced
cholangiocarcinoma treated with percutaneous transhepatic
drainage

J 2025

Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Matej STRAKA; Jan ZAVADIL et al.

Základní údaje

Originální název

Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage

Autoři

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Matej STRAKA; Jan ZAVADIL; Michal EID; Michal UHER; Marek DOSTÁL a Tomáš ANDRAŠINA

Vydání

Scientific Reports, BERLIN, NATURE PORTFOLIO, 2025, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900 v roce 2024

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/25:00140600

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Percutaneous transhepatic biliary drainage; Biliary malignancy; Biliary stenosis; Metal stent; Prognostic factors; Scoring system

Štítky

14110212, 14110216, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 7. 2025 17:11, Mgr. Petra Trembecká, Ph.D.

Anotace

V originále

Biliary drainage is then one of the necessary procedures to help patients suffering from icterus to reduce serum bilirubin levels and relieve symptoms. The aim of this study was identifying risk factors for survival in patients with cholangiocarcinoma (CCA) treated with percutaneous transhepatic biliary drainage (PTBD) and to develop a simple scoring system predicting survival from PTBD insertion. This single-centre retrospective study included 175 consecutive patients undergoing PTBD for extrahepatic CCA (perihilar and distal). Prognostic factors affecting survival of patients with CCA treated with PTBD were analysed. A multivariate analysis showed that mass forming tumor with mass larger than 5 cm and presence of metastasis at the time of PTBD served as a negative prognostic factor (p = 0.002), better survival was associated with lower preprocedural bilirubin and lower CRP (p = 0.003). Multivariate analysis identified two significant risk factors for 3-month mortality: mass-forming tumors and bilirubin levels exceeding 185 mu mol/L. A simple scoring system was developed to predict 3-month mortality after PTBD in patients with advanced CCA, demonstrating 86.3% negative predictive value and 43.2% positive predictive value.

Návaznosti

MUNI/A/1558/2023, interní kód MU

Název: Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit XI

Investor: Masarykova univerzita, Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit XI

MUNI/A/1611/2023, interní kód MU

Název: Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

Investor: Masarykova univerzita, Vyhodnocení účinnosti a optimalizace protokolů radiologických zobrazovacích a intervenčních metod - 2.část

NU21-08-00561, projekt VaV

Název: Využití ireverzibilní elektroporace a vysokofrekvenční ireverzibilní elektroporace k léčbě okluzí metalických stentů

Investor: Ministerstvo zdravotnictví ČR, Využití ireverzibilní elektroporace a vysokofrekvenční ireverzibilní elektroporace k léčbě okluzí metalických stentů, Podprogram 1 - standardní

Citovat

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Matej STRAKA; Jan ZAVADIL; Michal EID; Michal UHER; Marek DOSTÁL a Tomáš ANDRAŠINA. Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage. Scientific Reports. BERLIN: NATURE PORTFOLIO, 2025, roč. 15, č. 1, s. 1-10. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-86443-8.

@article{2474622,
   author = {Rohan, Tomáš and Hanžlová, Barbora and Matkulčík, Peter and Straka, Matej and Zavadil, Jan and Eid, Michal and Uher, Michal and Dostál, Marek and Andrašina, Tomáš},
   article_location = {BERLIN},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-025-86443-8},
   keywords = {Percutaneous transhepatic biliary drainage; Biliary malignancy; Biliary stenosis; Metal stent; Prognostic factors; Scoring system},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage},
   url = {https://www.nature.com/articles/s41598-025-86443-8},
   volume = {15},
   year = {2025}
}

TY  - JOUR
ID  - 2474622
AU  - Rohan, Tomáš - Hanžlová, Barbora - Matkulčík, Peter - Straka, Matej - Zavadil, Jan - Eid, Michal - Uher, Michal - Dostál, Marek - Andrašina, Tomáš
PY  - 2025
TI  - Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage
JF  - Scientific Reports
VL  - 15
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - NATURE PORTFOLIO
SN  - 20452322
KW  - Percutaneous transhepatic biliary drainage
KW  - Biliary malignancy
KW  - Biliary stenosis
KW  - Metal stent
KW  - Prognostic factors
KW  - Scoring system
UR  - https://www.nature.com/articles/s41598-025-86443-8
N2  - Biliary drainage is then one of the necessary procedures to help patients suffering from icterus to reduce serum bilirubin levels and relieve symptoms. The aim of this study was identifying risk factors for survival in patients with cholangiocarcinoma (CCA) treated with percutaneous transhepatic biliary drainage (PTBD) and to develop a simple scoring system predicting survival from PTBD insertion. This single-centre retrospective study included 175 consecutive patients undergoing PTBD for extrahepatic CCA (perihilar and distal). Prognostic factors affecting survival of patients with CCA treated with PTBD were analysed. A multivariate analysis showed that mass forming tumor with mass larger than 5 cm and presence of metastasis at the time of PTBD served as a negative prognostic factor (p = 0.002), better survival was associated with lower preprocedural bilirubin and lower CRP (p = 0.003). Multivariate analysis identified two significant risk factors for 3-month mortality: mass-forming tumors and bilirubin levels exceeding 185 mu mol/L. A simple scoring system was developed to predict 3-month mortality after PTBD in patients with advanced CCA, demonstrating 86.3% negative predictive value and 43.2% positive predictive value.
ER  -

ROHAN, Tomáš; Barbora HANŽLOVÁ; Peter MATKULČÍK; Matej STRAKA; Jan ZAVADIL; Michal EID; Michal UHER; Marek DOSTÁL a Tomáš ANDRAŠINA. Prognostic factors for survival in patients with advanced cholangiocarcinoma treated with percutaneous transhepatic drainage. \textit{Scientific Reports}. BERLIN: NATURE PORTFOLIO, 2025, roč.~15, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-025-86443-8.

Přehled o publikaci