The Molecular Landscape of 227 Adult Granulosa Cell Tumors of
the Ovary: Insights into the Progression from Primary to
Recurrence

J 2025

The Molecular Landscape of 227 Adult Granulosa Cell Tumors of the Ovary: Insights into the Progression from Primary to Recurrence

MICHALKOVA, Romana; Adam SAFANDA; Nikola HAJKOVA; Jan HOJNY; Eva KRKAVCOVA et al.

Základní údaje

Originální název

The Molecular Landscape of 227 Adult Granulosa Cell Tumors of the Ovary: Insights into the Progression from Primary to Recurrence

Autoři

Vydání

Laboratory Investigation, NEW YORK, ELSEVIER, 2025, 0023-6837

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.200 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

adult-type granulosa cell tumor of the ovary; DICER1; FOXO1; FOXL2; KMT2D; TERT promoter

Štítky

14110230, 14110813, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 1. 2026 13:01, Mgr. Tereza Miškechová

Anotace

V originále

Adult granulosa cell tumors (AGCTs) of the ovary are characterized by their propensity for late recurrences and are primarily managed surgically due to the limited efficacy of systemic treatment. The FOXL2 p.C134W somatic mutation has been identified in similar to 95% of AGCT cases, and TERT promoter alterations have been linked to worse overall survival. This study highlights the potential prognostic significance of FOXO1 mutations, suggesting that they may be associated with poorer overall survival and shorter time to recurrence. A total of 183 primary AGCTs and 44 recurrences without corresponding primary tumors were analyzed. The primary AGCTs were categorized into 3 groups: 77 nonrecurrent tumors, 18 tumors that later recurred (including 9 cases with matched primary-recurrence pairs), and 88 tumors with unknown recurrence status. Targeted next- generation sequencing was conducted on 786 cancer-related genes to investigate their genetic profile. The study aimed to identify the molecular alterations associated with AGCT pathogenesis and recurrence rate, comparing primary versus recurrent tumors, and primary recurrent versus primary nonrecurrent cases.

Návaznosti

90233, velká výzkumná infrastruktura

Název: BBMRI.cz IV

Citovat

MICHALKOVA, Romana; Adam SAFANDA; Nikola HAJKOVA; Jan HOJNY; Eva KRKAVCOVA; Michaela KENDALL BARTU; Marian SVAJDLER; Tetiana SHATOKHINA; Jan LACO; Radoslav MATEJ; Gabor MEHES; Jitka HAUSNEROVÁ; Jozef SKARDA; Maria HACOVA; Monika NÁLEŽINSKÁ; Tomas ZIMAL; Pavel DUNDR a Kristyna NEMEJCOVA. The Molecular Landscape of 227 Adult Granulosa Cell Tumors of the Ovary: Insights into the Progression from Primary to Recurrence. Laboratory Investigation. NEW YORK: ELSEVIER, 2025, roč. 105, č. 3, s. 1-10. ISSN 0023-6837. Dostupné z: https://doi.org/10.1016/j.labinv.2024.102201.

@article{2474623,
   author = {Michalkova, Romana and Safanda, Adam and Hajkova, Nikola and Hojny, Jan and Krkavcova, Eva and Kendall Bartu, Michaela and Svajdler, Marian and Shatokhina, Tetiana and Laco, Jan and Matej, Radoslav and Mehes, Gabor and Hausnerová, Jitka and Skarda, Jozef and Hacova, Maria and Náležinská, Monika and Zimal, Tomas and Dundr, Pavel and Nemejcova, Kristyna},
   article_location = {NEW YORK},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.labinv.2024.102201},
   keywords = {adult-type granulosa cell tumor of the ovary; DICER1; FOXO1; FOXL2; KMT2D; TERT promoter},
   language = {eng},
   issn = {0023-6837},
   journal = {Laboratory Investigation},
   title = {The Molecular Landscape of 227 Adult Granulosa Cell Tumors of the Ovary: Insights into the Progression from Primary to Recurrence},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S0023683724018798?via%3Dihub},
   volume = {105},
   year = {2025}
}

TY  - JOUR
ID  - 2474623
AU  - Michalkova, Romana - Safanda, Adam - Hajkova, Nikola - Hojny, Jan - Krkavcova, Eva - Kendall Bartu, Michaela - Svajdler, Marian - Shatokhina, Tetiana - Laco, Jan - Matej, Radoslav - Mehes, Gabor - Hausnerová, Jitka - Skarda, Jozef - Hacova, Maria - Náležinská, Monika - Zimal, Tomas - Dundr, Pavel - Nemejcova, Kristyna
PY  - 2025
TI  - The Molecular Landscape of 227 Adult Granulosa Cell Tumors of the Ovary: Insights into the Progression from Primary to Recurrence
JF  - Laboratory Investigation
VL  - 105
IS  - 3
SP  - 1-10
EP  - 1-10
PB  - ELSEVIER
SN  - 00236837
KW  - adult-type granulosa cell tumor of the ovary
KW  - DICER1
KW  - FOXO1
KW  - FOXL2
KW  - KMT2D
KW  - TERT promoter
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0023683724018798?via%3Dihub
N2  - Adult granulosa cell tumors (AGCTs) of the ovary are characterized by their propensity for late recurrences and are primarily managed surgically due to the limited efficacy of systemic treatment. The FOXL2 p.C134W somatic mutation has been identified in similar to 95% of AGCT cases, and TERT promoter alterations have been linked to worse overall survival. This study highlights the potential prognostic significance of FOXO1 mutations, suggesting that they may be associated with poorer overall survival and shorter time to recurrence. A total of 183 primary AGCTs and 44 recurrences without corresponding primary tumors were analyzed. The primary AGCTs were categorized into 3 groups: 77 nonrecurrent tumors, 18 tumors that later recurred (including 9 cases with matched primary-recurrence pairs), and 88 tumors with unknown recurrence status. Targeted next- generation sequencing was conducted on 786 cancer-related genes to investigate their genetic profile. The study aimed to identify the molecular alterations associated with AGCT pathogenesis and recurrence rate, comparing primary versus recurrent tumors, and primary recurrent versus primary nonrecurrent cases.
ER  -

MICHALKOVA, Romana; Adam SAFANDA; Nikola HAJKOVA; Jan HOJNY; Eva KRKAVCOVA; Michaela KENDALL BARTU; Marian SVAJDLER; Tetiana SHATOKHINA; Jan LACO; Radoslav MATEJ; Gabor MEHES; Jitka HAUSNEROVÁ; Jozef SKARDA; Maria HACOVA; Monika NÁLEŽINSKÁ; Tomas ZIMAL; Pavel DUNDR a Kristyna NEMEJCOVA. The Molecular Landscape of 227 Adult Granulosa Cell Tumors of the Ovary: Insights into the Progression from Primary to Recurrence. \textit{Laboratory Investigation}. NEW YORK: ELSEVIER, 2025, roč.~105, č.~3, s.~1-10. ISSN~0023-6837. Dostupné z: https://doi.org/10.1016/j.labinv.2024.102201.

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