Regulation of Cell-Nanoparticle Interactions through
Mechanobiology

J 2025

Regulation of Cell-Nanoparticle Interactions through Mechanobiology

CASSANI, Marco; Francesco NIRO; Soraia FERNANDES; Daniel PEREIRA DE SOUSA; Sofia MORAZZO et al.

Základní údaje

Originální název

Regulation of Cell-Nanoparticle Interactions through Mechanobiology

Autoři

Vydání

NANO LETTERS, WASHINGTON, AMER CHEMICAL SOC, 2025, 1530-6984

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.100 v roce 2024

Označené pro přenos do RIV

Ano

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

nanoparticles; bio-nano interactions; mechanobiology; mechanotransduction

Štítky

14110513, 14313050, CF BIOIT, CF GEN, CF NANO, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 3. 2026 12:39, Mgr. Eva Dubská

Anotace

V originále

Bio-nano interactions have been extensively explored in nanomedicine to develop selective delivery strategies and reduce systemic toxicity. To enhance the delivery of nanocarriers to cancer cells and improve the therapeutic efficiency, different nanomaterials have been developed. However, the limited clinical translation of nanoparticle-based therapies, largely due to issues associated with poor targeting, requires a deeper understanding of the biological phenomena underlying cell-nanoparticle interactions. In this context, we investigate the molecular and cellular mechanobiology parameters that control such interactions. We demonstrate that the pharmacological inhibition or the genetic ablation of the key mechanosensitive component of the Hippo pathway, i.e., yes-associated protein, enhances nanoparticle internalization by 1.5-fold. Importantly, this phenomenon occurs independently of nanoparticle properties, such as size, or cell properties such as surface area and stiffness. Our study reveals that the internalization of nanoparticles in target cells can be controlled by modulating cell mechanosensing pathways, potentially enhancing nanotherapy specificity.

Návaznosti

EF18_046/0015974, projekt VaV

Název: Modernizace České infrastruktury pro integrativní strukturní biologii

LM2023042, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CIISB - Česká infrastruktura pro integrativní strukturní biologii

90132, velká výzkumná infrastruktura

Název: NCMG II

964997, interní kód MU

Název: Alliance for Life Sciences: From Strategies to Actions in Central and Eastern Europe (Akronym: A4L_ACTIONS)

Investor: Evropská unie, Alliance for Life Sciences: From Strategies to Actions in Central and Eastern Europe, Health, demographic change and wellbeing (Societal Challenges)

Citovat

CASSANI, Marco; Francesco NIRO; Soraia FERNANDES; Daniel PEREIRA DE SOUSA; Sofia MORAZZO; Helena DURIKOVA; Tianzheng WANG; Lara GONZALEZ-CABALEIRO; Jan VRBSKY; La Cruz Jorge OLIVER-DE; Šimon VRANA; Jan PŘIBYL; Tomáš LOJA; Petr SKLÁDAL; Frank CARUSO a Giancarlo FORTE. Regulation of Cell-Nanoparticle Interactions through Mechanobiology. NANO LETTERS. WASHINGTON: AMER CHEMICAL SOC, 2025, roč. 25, č. 7, s. 2600-2609. ISSN 1530-6984. Dostupné z: https://doi.org/10.1021/acs.nanolett.4c04290.

@article{2474818,
   author = {Cassani, Marco and Niro, Francesco and Fernandes, Soraia and Pereira de Sousa, Daniel and Morazzo, Sofia and Durikova, Helena and Wang, Tianzheng and GonzalezandCabaleiro, Lara and Vrbsky, Jan and OliverandDe, La Cruz Jorge and Vrana, Šimon and Přibyl, Jan and Loja, Tomáš and Skládal, Petr and Caruso, Frank and Forte, Giancarlo},
   article_location = {WASHINGTON},
   article_number = {7},
   doi = {https://doi.org/10.1021/acs.nanolett.4c04290},
   keywords = {nanoparticles; bio-nano interactions; mechanobiology; mechanotransduction},
   language = {eng},
   issn = {1530-6984},
   journal = {NANO LETTERS},
   title = {Regulation of Cell-Nanoparticle Interactions through Mechanobiology},
   url = {https://pubs.acs.org/doi/10.1021/acs.nanolett.4c04290#},
   volume = {25},
   year = {2025}
}

TY  - JOUR
ID  - 2474818
AU  - Cassani, Marco - Niro, Francesco - Fernandes, Soraia - Pereira de Sousa, Daniel - Morazzo, Sofia - Durikova, Helena - Wang, Tianzheng - Gonzalez-Cabaleiro, Lara - Vrbsky, Jan - Oliver-De, La Cruz Jorge - Vrana, Šimon - Přibyl, Jan - Loja, Tomáš - Skládal, Petr - Caruso, Frank - Forte, Giancarlo
PY  - 2025
TI  - Regulation of Cell-Nanoparticle Interactions through Mechanobiology
JF  - NANO LETTERS
VL  - 25
IS  - 7
SP  - 2600-2609
EP  - 2600-2609
PB  - AMER CHEMICAL SOC
SN  - 15306984
KW  - nanoparticles
KW  - bio-nano interactions
KW  - mechanobiology
KW  - mechanotransduction
UR  - https://pubs.acs.org/doi/10.1021/acs.nanolett.4c04290#
N2  - Bio-nano interactions have been extensively explored in nanomedicine to develop selective delivery strategies and reduce systemic toxicity. To enhance the delivery of nanocarriers to cancer cells and improve the therapeutic efficiency, different nanomaterials have been developed. However, the limited clinical translation of nanoparticle-based therapies, largely due to issues associated with poor targeting, requires a deeper understanding of the biological phenomena underlying cell-nanoparticle interactions. In this context, we investigate the molecular and cellular mechanobiology parameters that control such interactions. We demonstrate that the pharmacological inhibition or the genetic ablation of the key mechanosensitive component of the Hippo pathway, i.e., yes-associated protein, enhances nanoparticle internalization by 1.5-fold. Importantly, this phenomenon occurs independently of nanoparticle properties, such as size, or cell properties such as surface area and stiffness. Our study reveals that the internalization of nanoparticles in target cells can be controlled by modulating cell mechanosensing pathways, potentially enhancing nanotherapy specificity.
ER  -

CASSANI, Marco; Francesco NIRO; Soraia FERNANDES; Daniel PEREIRA DE SOUSA; Sofia MORAZZO; Helena DURIKOVA; Tianzheng WANG; Lara GONZALEZ-CABALEIRO; Jan VRBSKY; La Cruz Jorge OLIVER-DE; Šimon VRANA; Jan PŘIBYL; Tomáš LOJA; Petr SKLÁDAL; Frank CARUSO a Giancarlo FORTE. Regulation of Cell-Nanoparticle Interactions through Mechanobiology. \textit{NANO LETTERS}. WASHINGTON: AMER CHEMICAL SOC, 2025, roč.~25, č.~7, s.~2600-2609. ISSN~1530-6984. Dostupné z: https://doi.org/10.1021/acs.nanolett.4c04290.

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